RGD Reference Report - A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. - Rat Genome Database

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A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.

Authors: Fulle, HJ  Vassar, R  Foster, DC  Yang, RB  Axel, R  Garbers, DL 
Citation: Fulle HJ, etal., Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3571-5.
RGD ID: 68797
Pubmed: PMID:7724600   (View Abstract at PubMed)
PMCID: PMC42209   (View Article at PubMed Central)

We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a subpopulation of olfactory sensory neurons. The extracellular, putative ligand-binding domain of the olfactory cyclase is similar in primary structure to two guanylyl cyclases expressed in the retina but diverges considerably from other known guanylyl cyclases. The expression of GC-D RNA is restricted to a small, randomly dispersed population of neurons that is within a single topographic zone in the olfactory neuroepithelium and resembles the pattern of the more diverse seven-transmembrane-domain odorant receptors. These observations suggest that GC-D may function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
guanylate cyclase activity enablesIDA 68797PMID:7724600MGI 

Objects Annotated

Genes (Rattus norvegicus)
Gucy2e  (guanylate cyclase 2E)


Additional Information