Gucy1a2 (guanylate cyclase 1 soluble subunit alpha 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gucy1a2 (guanylate cyclase 1 soluble subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Gucy1a2
Name: guanylate cyclase 1 soluble subunit alpha 2
RGD ID: 621655
Description: Enables guanylate cyclase activity. Predicted to be involved in response to oxygen levels. Predicted to act upstream of or within obsolete positive regulation of nitric oxide mediated signal transduction. Predicted to be located in cytosol. Predicted to be part of guanylate cyclase complex, soluble. Orthologous to human GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GCS-alpha-2; guanylate cyclase 1, soluble, alpha 2; guanylate cyclase soluble subunit alpha-2; LOC497842; similar to guanylate cyclase 1, soluble, alpha 2; soluble guanylyl cyclase alpha2 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr888,785,212 - 9,174,322 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl88,785,121 - 9,174,272 (+)EnsemblGRCr8
mRatBN7.28500,212 - 900,201 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8500,212 - 889,203 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx84,342,420 - 4,731,628 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.082,640,170 - 3,029,370 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08573,510 - 962,390 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd88,761,451 - 9,161,407 (+)NCBI
Lyon_Normotensive810,844,054 - 11,244,236 (+)NCBI
Lyon_Hypertensive89,453,872 - 9,854,062 (+)NCBI
F344_StmMcwi8898,773 - 1,298,747 (+)NCBI
Rnor_6.08408,001 - 899,851 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8408,001 - 899,974 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.08417,520 - 903,360 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48113,253 - 262,544 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8386,346 - 771,749 (+)NCBICelera
RGSC_v3.18113,252 - 262,544 (+)NCBI
Cytogenetic Map8q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
fonofos  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
glyphosate  (ISO)
graphite  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
kojic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS,TAS)
guanylate cyclase complex, soluble  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interaction of brain somatostatin receptors with the PDZ domains of PSD-95. Christenn M, etal., FEBS Lett. 2007 Nov 13;581(27):5173-7. Epub 2007 Oct 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide. Potential relevance to regulation of blood pressure. Gupta G, etal., J Clin Invest. 1997 Sep 15;100(6):1488-92. doi: 10.1172/JCI119670.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Cloning and functional expression of the rat alpha(2) subunit of soluble guanylyl cyclase. Koglin M and Behrends S, Biochim Biophys Acta 2000 Dec 1;1494(3):286-9.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. Russwurm M, etal., J Biol Chem 2001 Nov 30;276(48):44647-52.
Additional References at PubMed
PMID:20623   PMID:9925020   PMID:14687925   PMID:16569663   PMID:16614755   PMID:18572161   PMID:19141686   PMID:22608751   PMID:22806360   PMID:23579428  


Genomics

Comparative Map Data
Gucy1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr888,785,212 - 9,174,322 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl88,785,121 - 9,174,272 (+)EnsemblGRCr8
mRatBN7.28500,212 - 900,201 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8500,212 - 889,203 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx84,342,420 - 4,731,628 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.082,640,170 - 3,029,370 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08573,510 - 962,390 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd88,761,451 - 9,161,407 (+)NCBI
Lyon_Normotensive810,844,054 - 11,244,236 (+)NCBI
Lyon_Hypertensive89,453,872 - 9,854,062 (+)NCBI
F344_StmMcwi8898,773 - 1,298,747 (+)NCBI
Rnor_6.08408,001 - 899,851 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8408,001 - 899,974 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.08417,520 - 903,360 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48113,253 - 262,544 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8386,346 - 771,749 (+)NCBICelera
RGSC_v3.18113,252 - 262,544 (+)NCBI
Cytogenetic Map8q11NCBI
GUCY1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811106,674,019 - 107,018,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11106,674,019 - 107,018,538 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh3711106,544,745 - 106,889,202 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611106,063,120 - 106,394,381 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411106,063,119 - 106,394,381NCBI
Celera11103,723,340 - 104,055,014 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11102,477,634 - 102,824,743 (-)NCBIHuRef
CHM1_111106,428,121 - 106,772,413 (-)NCBICHM1_1
T2T-CHM13v2.011106,680,493 - 107,025,581 (-)NCBIT2T-CHM13v2.0
Gucy1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3993,532,349 - 3,905,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl93,532,778 - 3,905,741 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3893,532,349 - 3,905,791 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl93,532,778 - 3,894,736 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv3793,532,354 - 3,897,342 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3693,532,778 - 3,905,782 (+)NCBIMGSCv36mm8
Celera3118,798,542 - 119,162,647 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.14NCBI
Gucy1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554129,225,305 - 9,480,206 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554129,218,029 - 9,480,333 (-)NCBIChiLan1.0ChiLan1.0
GUCY1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29107,423,265 - 107,768,129 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111108,518,712 - 108,863,579 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011101,565,279 - 101,910,136 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111105,060,684 - 105,394,346 (-)NCBIPanPan1.1PanPan1.1panPan2
GUCY1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1525,291,019 - 25,718,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl525,291,583 - 25,686,947 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha525,216,400 - 25,557,679 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0525,315,662 - 25,746,950 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl525,316,274 - 25,715,102 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1525,369,411 - 25,798,051 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0525,255,743 - 25,598,578 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0525,321,581 - 25,750,065 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gucy1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1490,991,259 - 91,268,542 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440494789,719,092 - 89,961,167 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365511,575,356 - 1,814,697 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365511,573,930 - 1,814,685 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl962,101,613 - 62,499,581 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1962,101,581 - 62,510,803 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2968,952,382 - 69,391,579 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCY1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11103,158,156 - 103,488,342 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604327,490,497 - 27,809,576 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1198,108,081 - 98,439,453 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Gucy1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247841,449,275 - 1,796,331 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247841,452,008 - 1,796,252 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl560,731,722 - 61,131,691 (+)Ensembl
Gucy1a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18207,477 - 291,309 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Gucy1a2
3468 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000046058
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat

Markers in Region
RH127087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21465,683,640 - 65,683,847 (+)MAPPERmRatBN7.2
mRatBN7.28819,421 - 819,628 (+)MAPPERmRatBN7.2
Rnor_6.08833,086 - 833,292NCBIRnor6.0
Rnor_6.01470,178,072 - 70,178,278NCBIRnor6.0
Rnor_5.01470,221,256 - 70,221,462UniSTSRnor5.0
Rnor_5.08836,484 - 836,690UniSTSRnor5.0
RGSC_v3.41470,755,388 - 70,755,594UniSTSRGSC3.4
RGSC_v3.48190,903 - 191,109UniSTSRGSC3.4
Celera8704,176 - 704,382UniSTS
Celera1464,664,740 - 64,664,946UniSTS
Cytogenetic Map8q11UniSTS
Cytogenetic Map14q21UniSTS
AU048567  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera8469,870 - 469,989UniSTS
Cytogenetic Map8q11UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
275 108 696 1585 4033 969 1682 125 832 271 814 145 4949 2345 331 3947 38 1294 725 906 158 156

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_023956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB079780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB096080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB097860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF109963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY795577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000046058   ⟹   ENSRNOP00000040361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl88,785,121 - 9,174,272 (+)Ensembl
mRatBN7.2 Ensembl8500,212 - 889,203 (+)Ensembl
Rnor_6.0 Ensembl8408,001 - 899,974 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094766   ⟹   ENSRNOP00000091775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl88,785,121 - 9,167,465 (+)Ensembl
mRatBN7.2 Ensembl8500,212 - 598,845 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159015   ⟹   ENSRNOP00000106453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl88,785,121 - 9,174,272 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170498   ⟹   ENSRNOP00000098928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl88,785,121 - 9,174,272 (+)Ensembl
RefSeq Acc Id: NM_023956   ⟹   NP_076446
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr888,785,212 - 9,174,159 (+)NCBI
mRatBN7.28500,212 - 889,203 (+)NCBI
Dahl_SR_JrHsd88,761,451 - 9,161,407 (+)NCBI
Lyon_Normotensive810,844,054 - 11,244,236 (+)NCBI
Lyon_Hypertensive89,453,872 - 9,854,062 (+)NCBI
F344_StmMcwi8898,773 - 1,298,747 (+)NCBI
Rnor_6.08408,001 - 899,851 (+)NCBI
Rnor_5.08417,520 - 903,360 (+)NCBI
RGSC_v3.48113,253 - 262,544 (+)RGD
Celera8386,346 - 771,749 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082124   ⟹   XP_038938052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr888,785,632 - 8,917,000 (+)NCBI
mRatBN7.28500,604 - 608,248 (+)NCBI
RefSeq Acc Id: XM_039082125   ⟹   XP_038938053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr888,785,632 - 9,174,322 (+)NCBI
mRatBN7.28500,604 - 900,201 (+)NCBI
RefSeq Acc Id: XM_039082127   ⟹   XP_038938055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr888,785,632 - 9,174,322 (+)NCBI
mRatBN7.28500,604 - 900,201 (+)NCBI
RefSeq Acc Id: XM_063266107   ⟹   XP_063122177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr888,785,632 - 9,174,322 (+)NCBI
RefSeq Acc Id: XM_063266108   ⟹   XP_063122178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr888,816,445 - 9,174,322 (+)NCBI
RefSeq Acc Id: XM_063266109   ⟹   XP_063122179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr888,834,171 - 9,174,322 (+)NCBI
RefSeq Acc Id: XM_063266110   ⟹   XP_063122180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr888,785,632 - 8,920,756 (+)NCBI
RefSeq Acc Id: NP_076446   ⟸   NM_023956
- UniProtKB: Q54A43 (UniProtKB/Swiss-Prot),   Q9WVI4 (UniProtKB/Swiss-Prot),   Q8CH90 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040361   ⟸   ENSRNOT00000046058
RefSeq Acc Id: XP_038938055   ⟸   XM_039082127
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QK06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938053   ⟸   XM_039082125
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QK06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938052   ⟸   XM_039082124
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000091775   ⟸   ENSRNOT00000094766
RefSeq Acc Id: XP_063122177   ⟸   XM_063266107
- Peptide Label: isoform X1
- UniProtKB: Q8CH90 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122180   ⟸   XM_063266110
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063122178   ⟸   XM_063266108
- Peptide Label: isoform X3
- UniProtKB: Q8CH90 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122179   ⟸   XM_063266109
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000106453   ⟸   ENSRNOT00000159015
Ensembl Acc Id: ENSRNOP00000098928   ⟸   ENSRNOT00000170498
Protein Domains
Guanylate cyclase   H-NOX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVI4-F1-model_v2 AlphaFold Q9WVI4 1-730 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621655 AgrOrtholog
BioCyc Gene G2FUF-31848 BioCyc
Ensembl Genes ENSRNOG00000029876 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006026 UniProtKB/Swiss-Prot
  ENSRNOG00060015826 UniProtKB/Swiss-Prot
  ENSRNOG00065002755 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046058 ENTREZGENE
  ENSRNOT00000170498 ENTREZGENE
  ENSRNOT00000170498.1 UniProtKB/Swiss-Prot
  ENSRNOT00055009757 UniProtKB/Swiss-Prot
  ENSRNOT00060027104 UniProtKB/Swiss-Prot
  ENSRNOT00065003767 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.450.260 UniProtKB/Swiss-Prot
  3.30.70.1230 UniProtKB/Swiss-Prot
  3.90.1520.10 UniProtKB/Swiss-Prot
  6.10.250.780 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  H-NOX_domain_sf UniProtKB/Swiss-Prot
  Heme_NO-bd UniProtKB/Swiss-Prot
  HNOB_dom_associated UniProtKB/Swiss-Prot
  HNOB_dom_associated_sf UniProtKB/Swiss-Prot
  NO_sig/Golgi_transp_ligand-bd UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
KEGG Report rno:66012 UniProtKB/Swiss-Prot
NCBI Gene 66012 ENTREZGENE
PANTHER GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2 UniProtKB/Swiss-Prot
  GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 UniProtKB/Swiss-Prot
Pfam Guanylate_cyc UniProtKB/Swiss-Prot
  HNOB UniProtKB/Swiss-Prot
  HNOBA UniProtKB/Swiss-Prot
PhenoGen Gucy1a2 PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
  H_NOX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029876 RatGTEx
  ENSRNOG00055006026 RatGTEx
  ENSRNOG00060015826 RatGTEx
  ENSRNOG00065002755 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111126 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
UniProt A0A8I6AGA3_RAT UniProtKB/TrEMBL
  A0A8L2QK06 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LWE6_RAT UniProtKB/TrEMBL
  GCYA2_RAT UniProtKB/Swiss-Prot
  Q54A43 ENTREZGENE
  Q8CH90 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVI4 ENTREZGENE
UniProt Secondary Q54A43 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Gucy1a2  guanylate cyclase 1 soluble subunit alpha 2  Gucy1a2  guanylate cyclase 1, soluble, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Gucy1a2  guanylate cyclase 1, soluble, alpha 2  LOC497842  similar to guanylate cyclase 1, soluble, alpha 2  Data merged from RGD:1583747 737654 PROVISIONAL
2006-11-19 LOC497842  similar to guanylate cyclase 1, soluble, alpha 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Gucy1a2  guanylate cyclase 1, soluble, alpha 2    soluble guanylyl cyclase alpha2 subunit  Name updated 1299863 APPROVED
2002-08-07 Gucy1a2  soluble guanylyl cyclase alpha2 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL