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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Hepatitis B
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Accession:DOID:9008163 term browser browse the term
Definition:INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
Synonyms:primary_id: MESH:D019694

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Chronic Hepatitis B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase RNA specific treatment ISO DNA:SNP:enhancer: (rs4845384) (human) RGD PMID:24351124 RGD:125097515 NCBI chrNW_004936580:4,183,016...4,208,341
Ensembl chrNW_004936580:4,183,079...4,203,435 		JBrowse link
G Apoa1 apolipoprotein A1 ISO protein:decreased expression:plasma (human)
mRNA, protein:decreased expression:liver, serum (human)		 RGD PMID:21726101 PMID:25115832 PMID:27015844 RGD:25671432 RGD:25671433 RGD:5508214 NCBI chrNW_004936542:2,111,055...2,112,626
Ensembl chrNW_004936542:2,111,052...2,112,854 		JBrowse link
G Apoe apolipoprotein E susceptibility ISO DNA:missense mutations:cds:p.C112R, p.R158C (human) RGD PMID:20961200 RGD:14401585 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Birc3 baculoviral IAP repeat containing 3 ameliorates ISO RGD PMID:25902529 RGD:152998939 NCBI chrNW_004936551:5,544,047...5,556,550
Ensembl chrNW_004936551:5,544,065...5,556,555 		JBrowse link
G C2 complement C2 susceptibility ISO DNA:SNP:exon: p.Glu318Asp (human) RGD PMID:22610944 RGD:40886317 NCBI chrNW_004936727:1,602,400...1,615,974
Ensembl chrNW_004936727:1,602,398...1,616,060 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 severity ISO RGD PMID:17711627 RGD:14995339 NCBI chrNW_004936490:253,279...259,947
Ensembl chrNW_004936490:253,034...259,965 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17657819 NCBI chrNW_004936560:42,561...45,748
Ensembl chrNW_004936560:42,537...45,807 		JBrowse link
G Cd274 CD274 molecule treatment ISO protein:increased expression:regulatory T cell RGD PMID:20460044 PMID:26266813 RGD:11344683 RGD:41412166 NCBI chrNW_004936539:132,870...145,288
Ensembl chrNW_004936539:132,868...143,602 		JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 susceptibility ISO DNA:SNP:exon: p.Ser1254Asn (human) RGD PMID:22610944 RGD:40886317 NCBI chrNW_004936503:7,750,353...7,826,408
Ensembl chrNW_004936503:7,750,352...7,825,554 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 susceptibility ISO DNA:SNP: :-318C>T(human) RGD PMID:16489681 RGD:14398727 NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 treatment ISO mRNA,protein:increased expression: peripheral blood mononuclear cell,serum, sinusoidal endothelium RGD PMID:18234638 PMID:30660173 RGD:27095888 RGD:27095951 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO RGD PMID:26234401 RGD:32716425 NCBI chrNW_004936712:413,602...454,443
Ensembl chrNW_004936712:414,446...454,449 		JBrowse link
G Foxp3 forkhead box P3 ISO mRNA,protein:increased expression:peripheral blood mononuclear cell, liver: RGD PMID:18673437 PMID:21489307 RGD:38548921 RGD:38549358 NCBI chrNW_004936721:1,118,376...1,125,282
Ensembl chrNW_004936721:1,118,782...1,132,308 		JBrowse link
G Gpt glutamic--pyruvic transaminase disease_progression
treatment		 ISO RGD PMID:28007350 PMID:29279233 RGD:14975159 RGD:14975240 NCBI chrNW_004936470:7,765,810...7,770,837
Ensembl chrNW_004936470:7,765,703...7,768,465 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO protein:increased expression:serum (human) RGD PMID:28465467 RGD:39939037 NCBI chrNW_004936843:658,058...672,662
Ensembl chrNW_004936843:657,979...672,700 		JBrowse link
G Ifng interferon gamma ISO protein:decreased expression:serum (human) RGD PMID:26684441 PMID:28465467 RGD:14974255 RGD:39939037 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Il12a interleukin 12A ISO mRNA:increased expression:liver RGD PMID:26062743 RGD:11097839 NCBI chrNW_004936519:6,166,060...6,180,652
Ensembl chrNW_004936519:6,175,261...6,180,396 		JBrowse link
G Il12b interleukin 12B susceptibility ISO DNA:SNP:3'utr: (rs3212227) RGD PMID:25469587 RGD:11074616 NCBI chrNW_004936515:4,056,214...4,066,121
Ensembl chrNW_004936515:4,056,214...4,065,076 		JBrowse link
G Il18 interleukin 18 disease_progression ISO DNA:SNP:promoter:-607C>A(human) RGD PMID:27470888 RGD:14696663 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il1rl1 interleukin 1 receptor like 1 severity ISO protein:increased expression:serum: RGD PMID:27180842 PMID:28381383 RGD:39457933 RGD:39938857 NCBI chrNW_004936713:1,020,969...1,035,012
Ensembl chrNW_004936713:1,021,044...1,035,039 		JBrowse link
G Il2 interleukin 2 susceptibility ISO DNA:polymorphism:promoter:-385T>G(human) RGD PMID:19105930 RGD:14747034 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Il21 interleukin 21 treatment
susceptibility
exacerbates		 ISO DNA:SNPs:introns: (rs2221903, rs907715) (human)
DNA:SNP:intron: (rs2221903) (human)
associated with non-alcoholic fatty liver disease
protein:decreased expression:blood serum (human)
protein:increased expression:blood serum (human)		 RGD PMID:23354321 PMID:25243706 PMID:26840345 PMID:28500636 PMID:29879024 More... RGD:127285353 RGD:127285361 RGD:127285364 RGD:127285369 RGD:127285378 RGD:127285539 RGD:127285549 RGD:127285551 NCBI chrNW_004936662:1,689,879...1,696,883
Ensembl chrNW_004936662:1,689,879...1,696,883 		JBrowse link
G Il33 interleukin 33 severity
treatment		 ISO RGD PMID:25714983 PMID:27180842 RGD:39457933 RGD:39938954 NCBI chrNW_004936539:763,755...791,461
Ensembl chrNW_004936539:623,248...791,470 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 ISO protein:increased expression:serum RGD PMID:24836184 RGD:40903002 NCBI chrNW_004936473:3,573,282...3,589,345
Ensembl chrNW_004936473:3,573,384...3,589,345 		JBrowse link
G Jak1 Janus kinase 1 disease_progression ISO DNA:SNPs: :rs4244165, rs17127024 (human) RGD PMID:22901011 RGD:19165132 NCBI chrNW_004936692:2,298,149...2,354,084
Ensembl chrNW_004936692:2,299,504...2,354,132 		JBrowse link
G Keap1 kelch like ECH associated protein 1 ISO mRNA:decreased expression:liver (human) RGD PMID:22459801 RGD:6892954 NCBI chrNW_004936659:785,059...793,775
Ensembl chrNW_004936659:782,340...793,688 		JBrowse link
G Krt18 keratin 18 disease_progression
severity		 ISO protein:increased phosphorylation:liver (human)
protein:increased degradation:serum (human)		 RGD PMID:20334631 PMID:28579343 RGD:18337487 RGD:18337494 NCBI chrNW_004936512:10,290,706...10,294,647
Ensembl chrNW_004936512:10,290,690...10,294,651 		JBrowse link
G Lepr leptin receptor ISO mRNA:altered expression:liver, peripheral blood mononuclear cell RGD PMID:17060687 RGD:21079470 NCBI chrNW_004936591:5,771,371...5,846,177
Ensembl chrNW_004936591:5,774,326...5,836,444 		JBrowse link
G LOC101958908 HLA class II histocompatibility antigen, DP alpha 1 chain susceptibility
disease_progression
treatment		 ISO DNA:SNP: :rs3077(human)
DNA:polymorphism::HLA-DPA1*04:01(human)
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:peripheral blood mononuclear cell:		 RGD
CTD		 PMID:19349983 PMID:28275747 PMID:29300980 PMID:30267609 RGD:14694817 RGD:14694818 RGD:14694973 NCBI chrNW_004936476:25,743,512...25,750,809
Ensembl chrNW_004936476:25,743,456...25,750,907 		JBrowse link
G LOC101963197 HLA class II histocompatibility antigen, DP beta 1 chain susceptibility
treatment
severity		 ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphisms, haplotypes:multiple (human)
DNA:SNP:exon 6: (rs9277542) (human)
DNA:polymorphisms:multiple (human)
DNA:polymorphism: :(human)
DNA:SNP:exon, 3' utr: (rs9277542) (human)
DNA:polymorphism:exon, 3' utr: (rs9277535) (human)
DNA:SNPs:multiple (human)
DNA:SNP: :rs33054861(human)		 CTD
RGD		 PMID:19349983 PMID:21274863 PMID:21310144 PMID:22737229 PMID:24520320 More... RGD:11536957 RGD:14694816 RGD:14974232 RGD:150429660 RGD:150429794 RGD:150429799 RGD:150429802 RGD:150429807 RGD:150429808 NCBI chrNW_004936476:25,730,800...25,741,089
Ensembl chrNW_004936476:25,730,596...25,741,145 		JBrowse link
G LOC101964975 interleukin-8 severity ISO mRNA, protein:increased expression:serum, peripheral blood mononuclear cell (human)
associated with liver disease;mRNA, protein:increased expression:liver, blood serum (human)		 RGD PMID:23890815 PMID:26265888 RGD:11075958 RGD:150520196 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353 		JBrowse link
G LOC101976500 haptoglobin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16597321 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor ISO protein:decreased expression:blood serum (human) RGD PMID:28871230 RGD:150340590 NCBI chrNW_004936474:24,744,673...24,757,189
Ensembl chrNW_004936474:24,744,673...24,757,085 		JBrowse link
G Nfkbia NFKB inhibitor alpha disease_progression ISO DNA:enhancers: :(rs2233406, rs2233409) (human) RGD PMID:29093318 RGD:127285389 NCBI chrNW_004936494:9,537,793...9,541,187
Ensembl chrNW_004936494:9,537,008...9,541,612 		JBrowse link
G Pdcd1 programmed cell death 1 no_association
disease_progression		 ISO mRNA:increased expression:liver parenchyma (human)
protein:altered expression:serum:
DNA:SNP:exon:
DNA:SNPs::+7146 G>A,+7209 C>T(human)
DNA:SNP:3' UTR:rs10204525(human)		 RGD PMID:20700634 PMID:22634051 PMID:25736598 PMID:28983583 PMID:30016557 RGD:36947881 RGD:40818231 RGD:40818233 RGD:40818262 RGD:40818415 NCBI chrNW_004936745:152,571...163,712
Ensembl chrNW_004936745:152,612...161,587 		JBrowse link
G Ppp1r15a protein phosphatase 1 regulatory subunit 15A ISO mRNA,protein:increased expression:liver RGD PMID:26234401 RGD:32716425 NCBI chrNW_004936664:2,910,609...2,914,205 JBrowse link
G Prdm1 PR/SET domain 1 disease_progression ISO RGD PMID:31100710 RGD:150530465 NCBI chrNW_004936564:2,594,362...2,690,680
Ensembl chrNW_004936564:2,667,660...2,690,683 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 ISO mRNA:decreased expression:monocyte (human) RGD PMID:30842274 RGD:41789632 NCBI chrNW_004936646:747,178...763,449
Ensembl chrNW_004936646:748,727...761,287 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 susceptibility ISO DNA:SNPs, haplotypes:multiple RGD PMID:25829184 RGD:25671420 NCBI chrNW_004936506:7,091,982...7,185,938
Ensembl chrNW_004936506:7,095,009...7,184,689 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 susceptibility ISO DNA:hypermethylation:promoter RGD PMID:30593207 RGD:39128221 NCBI chrNW_004936531:8,555,966...8,562,829
Ensembl chrNW_004936531:8,555,637...8,562,885 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member ISO mRNA:decreased expression:blood RGD PMID:21843574 RGD:6482248 NCBI chrNW_004936476:25,899,514...25,907,690
Ensembl chrNW_004936476:25,899,339...25,907,695 		JBrowse link
G Tert telomerase reverse transcriptase susceptibility ISO DNA:SNP, haplotype: :rs10069690,rs2242652(human) RGD PMID:29507683 RGD:14696786 NCBI chrNW_004936815:468,987...492,666
Ensembl chrNW_004936815:469,020...491,697 		JBrowse link
G Tgfb1 transforming growth factor beta 1 no_association ISO DNA:SNPs:promoter:-509C>T (rs1800469) (human)
DNA:SNPs, haplotypes: :869C>T (rs1800470), 11929C>T (rs1800472) (human)		 RGD PMID:28700046 RGD:14995436 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
G Tlr2 toll like receptor 2 treatment
disease_progression		 ISO protein:increased expression:serum: RGD PMID:25337250 PMID:25771704 PMID:28414577 RGD:15090812 RGD:15090826 RGD:15090828 NCBI chrNW_004936576:522,234...531,660
Ensembl chrNW_004936576:527,434...529,788 		JBrowse link
G Tlr3 toll like receptor 3 susceptibility ISO DNA:SNP, haplotype: :1234C>T (human)
DNA:snp: :rs3775290(human)		 RGD PMID:23076446 PMID:26024592 RGD:21079416 RGD:21079425 NCBI chrNW_004936554:3,370,766...3,388,125
Ensembl chrNW_004936554:3,369,469...3,385,907 		JBrowse link
G Tlr4 toll like receptor 4 ISO protein:increased expression:serum: RGD PMID:28414577 RGD:15090812 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 susceptibility ISO DNA:SNP,haplotypes: (rs148314165, rs200820567) (human) RGD PMID:28784141 RGD:151347613 NCBI chrNW_004936560:5,124,955...5,138,988
Ensembl chrNW_004936560:5,128,843...5,138,345 		JBrowse link
G Tnfsf13b TNF superfamily member 13b treatment ISO RGD PMID:30660173 RGD:27095888 NCBI chrNW_004936472:3,789,111...3,834,163
Ensembl chrNW_004936472:3,788,095...3,822,148 		JBrowse link
G Ube2l3 ubiquitin conjugating enzyme E2 L3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24162738 NCBI chrNW_004936619:2,070,836...2,137,314
Ensembl chrNW_004936619:2,070,731...2,137,369 		JBrowse link
G Zfhx3 zinc finger homeobox 3 ISO protein:increased expression:blood serum (human) RGD PMID:20534899 RGD:151361169 NCBI chrNW_004936475:21,005,242...21,235,992
Ensembl chrNW_004936475:21,080,302...21,231,544 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14498
    disease by infectious agent 1968
      viral infectious disease 1499
        DNA Virus Infections 241
          Hepadnaviridae Infections 91
            hepatitis B 91
              Chronic Hepatitis B 50
Path 2
Term Annotations click to browse term
  disease 14498
    disease of anatomical entity 14147
      gastrointestinal system disease 6109
        hepatobiliary disease 2656
          liver disease 2555
            hepatitis 229
              viral hepatitis 153
                Human Viral Hepatitis 151
                  hepatitis B 91
                    Chronic Hepatitis B 50
paths to the root