RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Experimental Melanoma
Accession: DOID:9004118
browse the term
Definition: Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
Synonyms: exact_synonym: B16 Melanoma; B16 Melanomas; Cloudman S91 Melanoma; Experimental Melanomas; Harding Passey Melanoma
primary_id: MESH:D008546
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Acss1
acyl-CoA synthetase short-chain family member 1
treatment
ISO
RGD
PMID:27539851
RGD:13831304
NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325
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Acss2
acyl-CoA synthetase short-chain family member 2
treatment
ISO
RGD
PMID:27539851
RGD:13831304
NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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Antxr1
ANTXR cell adhesion molecule 1
treatment
ISO
RGD
PMID:19622764 PMID:19609240
RGD:9684925 , RGD:9684939
NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232
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Braf
B-Raf proto-oncogene, serine/threonine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29179997 PMID:29438700
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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Calr
calreticulin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16388313
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Ccl20
C-C motif chemokine ligand 20
treatment
ISO
RGD
PMID:14500387
RGD:7483600
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
treatment
ISO
RGD
PMID:24041689
RGD:7411680
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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Egr1
early growth response 1
ISO
mRNA, protein:increased expression:salivary gland (mouse)
RGD
PMID:19517020
RGD:5131885
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Esr2
estrogen receptor 2
severity
ISO
RGD
PMID:20354658
RGD:8694122
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Hgf
hepatocyte growth factor
ISO
RGD
PMID:9823327
RGD:8548620
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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Ifnb1
interferon beta 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16417267
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
RGD
PMID:19276165
RGD:7495758
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Il18
interleukin 18
treatment
ISO
RGD
PMID:12230493 PMID:17411412
RGD:8655870 , RGD:8655901
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1a
interleukin 1 alpha
treatment
ISO
RGD
PMID:8061895
RGD:7794735
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
ISO
RGD
PMID:1966551
RGD:7401226
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
ISO
RGD
PMID:11884028
RGD:8662950
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Kdm1a
lysine demethylase 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29438700
NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
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Kdm4c
lysine demethylase 4C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29438700
NCBI chr 5:88,100,710...88,306,821
Ensembl chr 5:88,100,733...88,306,818
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Mc1r
melanocortin 1 receptor
ISO
RGD
PMID:20126537
RGD:5687319
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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Pdcd1
programmed cell death 1
treatment
ISO
RGD
PMID:19208793
RGD:9589070
NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
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Pten
phosphatase and tensin homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29179997
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Pxn
paxillin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18492274
NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
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Tert
telomerase reverse transcriptase
treatment
ISO
RGD
PMID:19903903
RGD:11038656
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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