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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:hepatopulmonary syndrome
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Accession:DOID:900 term browser browse the term
Definition:A syndrome characterized by the clinical triad of advanced chronic liver disease, pulmonary vascular dilatations, and reduced arterial oxygenation (HYPOXEMIA) in the absence of intrinsic cardiopulmonary disease. This syndrome is common in the patients with LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL).
Synonyms:exact_synonym: Hepato Pulmonary Syndrome;   Hepato-Pulmonary Syndromes;   Hepatopulmonary Syndromes
 primary_id: MESH:D020065
 xref: EFO:1001346;   ICD10CM:K76.81;   ICD9CM:573.5


show annotations for term's descendants           Sort by:
hepatopulmonary syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP protein:increased expression:lung, plasma RGD PMID:22659346 RGD:9491778 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment IMP RGD PMID:22659346 RGD:9491778 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Edn1 endothelin 1 IEP protein:increased secretion:liver, plasma (rat) RGD PMID:15185300 RGD:4144891 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednrb endothelin receptor type B IEP protein:increased expression:lung RGD PMID:17110505 RGD:4892290 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Hmox1 heme oxygenase 1 IEP mRNA, protein:increased expression:lung RGD PMID:21518603 RGD:10755724 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP associated with Liver Cirrhosis;protein:increased expression:lung RGD PMID:18081228 RGD:2292110 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Tnf tumor necrosis factor treatment IMP RGD PMID:26236934 RGD:14696802 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A treatment IEP mRNA:increased expression:lung: RGD PMID:27029414 PMID:19109954 RGD:15003201, RGD:15036789 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    syndrome 10886
      hepatopulmonary syndrome 8
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18248
      gastrointestinal system disease 7094
        hepatobiliary disease 3068
          liver disease 2957
            hepatopulmonary syndrome 8
paths to the root