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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pituitary adenoma
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Accession:DOID:3829 term browser browse the term
Definition:A pituitary gland benign neoplasm that derives_from glandular epithelial cells. (DO)
Synonyms:exact_synonym: Pituitary Gland Adenoma;   adenoma of the pituitary gland;   pituitary adenomas
 broad_synonym: pituitary adenoma, multiple types
 xref: EFO:0002619;   EFO:1000478;   ICDO:8272/0;   NCI:C3329;   OMIM:PS102200;   ORDO:99408
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:28692683 RGD:14700668 NCBI chr 1:131,526,908...131,539,740
Ensembl chr 1:131,526,977...131,539,738 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO RGD PMID:12036912 RGD:619590 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO mRNA:altered expression:pituitary gland (human) RGD PMID:24169548 RGD:13792706 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
ACTH-secreting pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Pituitary adenoma, acth-secreting, somatic		 CTD
ClinVar		 PMID:17360484 PMID:18381572 PMID:19366855 PMID:20506337 PMID:20530095 More... NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:23884782 RGD:14700670 NCBI chr 1:131,526,908...131,539,740
Ensembl chr 1:131,526,977...131,539,738 		JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16195406 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO CTD Direct Evidence: marker/mechanism CTD
OMIM		 PMID:25485838 NCBI chr 2:126,549,280...126,601,234
Ensembl chr 2:126,549,248...126,601,217 		JBrowse link
Familial Isolated Pituitary Adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:22720333 PMID:24050928 PMID:25741868 PMID:26186299 PMID:26792934 More... NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Alk anaplastic lymphoma kinase ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:9536098 PMID:17576681 PMID:21838707 PMID:22072639 PMID:23104988 More... NCBI chr17:72,174,206...72,911,719
Ensembl chr17:72,175,967...72,911,622 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:25741868 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566 		JBrowse link
growth hormone secreting pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: Somatotroph adenoma ClinVar PMID:2200621 PMID:5320367 PMID:9482716 PMID:9536098 PMID:12213383 More... NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO protein:increased expression:pituitary gland: RGD PMID:18981426 RGD:8662821 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Gh growth hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:1611713 PMID:2042694 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691 		JBrowse link
G Gnas GNAS complex locus ISO CTD Direct Evidence: marker/mechanism CTD PMID:11254676 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Gpr101 G protein-coupled receptor 101 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr  X:56,542,028...56,549,117
Ensembl chr  X:56,542,028...56,549,117 		JBrowse link
G Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) ISO mRNA:decreased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078 		JBrowse link
G Men1 multiple endocrine neoplasia 1 IAGP
ISO		 OMIM:102200
ClinVar Annotator: match by term: Somatotroph adenoma		 MouseDO
ClinVar		 PMID:30630164 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2042694 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
growth hormone secreting pituitary adenoma 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr101 G protein-coupled receptor 101 ISO ClinVar Annotator: match by term: Pituitary adenoma, growth hormone-secreting, 2 OMIM
ClinVar		 PMID:25470569 PMID:25741868 PMID:25806919 PMID:25806920 PMID:25806921 More... NCBI chr  X:56,542,028...56,549,117
Ensembl chr  X:56,542,028...56,549,117 		JBrowse link
pituitary adenoma 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 1, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma predisposition
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:2200621 PMID:16728643 PMID:17244780 PMID:17341560 PMID:17360484 More... NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
pituitary adenoma 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnas GNAS complex locus ISO ClinVar Annotator: match by term: Pituitary adenoma 3, multiple types OMIM
ClinVar		 PMID:1505964 PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 More... NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Gnasas1 GNAS antisense RNA 1 ISO ClinVar Annotator: match by term: Pituitary adenoma 3, multiple types ClinVar PMID:25741868 NCBI chr 2:174,123,030...174,137,229
Ensembl chr 2:174,123,024...174,137,229 		JBrowse link
pituitary adenoma 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 PMID:28492532 NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Cdh23 cadherin related 23 (otocadherin) ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 5, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types OMIM
ClinVar		 PMID:2706105 PMID:9536098 PMID:11090341 PMID:11138009 PMID:11857743 More... NCBI chr10:60,138,527...60,532,291
Ensembl chr10:60,138,527...60,532,269 		JBrowse link
G Gm17455 predicted gene, 17455 ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 5, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:11138009 PMID:12075507 PMID:12522556 PMID:15537665 PMID:16199547 More... NCBI chr10:60,235,643...60,239,338
Ensembl chr10:60,235,505...60,239,338 		JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 PMID:28492532 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Vsir V-set immunoregulatory receptor ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 NCBI chr10:60,182,630...60,266,073
Ensembl chr10:60,182,630...60,208,463 		JBrowse link
prolactinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEP
ISO		 mRNA, protein:increased expression:pituitary gland
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16809920 PMID:12552124 RGD:629544 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:21980073 NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895 		JBrowse link
G Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) ISO mRNA:decreased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078 		JBrowse link
G Lrp2 low density lipoprotein receptor-related protein 2 ISO ClinVar Annotator: match by term: Prolactinoma, familial ClinVar PMID:17632512 PMID:25682901 PMID:25741868 PMID:28492532 NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409 		JBrowse link
G Men1 multiple endocrine neoplasia 1 IAGP OMIM:600634 MouseDO NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Myc myelocytomatosis oncogene ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:22635680 RGD:7240531 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nog noggin IEP mRNA, protein:decreased expression:pituitary RGD PMID:12552124 RGD:629544 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 ISO protein:increased expression:pars anterior RGD PMID:11026575 RGD:1625506 NCBI chr 8:67,132,617...67,140,746
Ensembl chr 8:67,132,617...67,140,780 		JBrowse link
G Prl prolactin sexual_dimorphism ISO DNA, mRNA:mutation, increased expression:pituitary gland
protein:increased expression:blood serum (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:718334 PMID:1407345 PMID:3776530 PMID:9617019 PMID:17260475 More... RGD:1642576, RGD:401976454, RGD:401960111 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16109
    disease of cellular proliferation 7517
      benign neoplasm 2219
        cell type benign neoplasm 1957
          adenoma 717
            pituitary adenoma 25
              acidophil adenoma 0
              basophil adenoma 0
              chromophobe adenoma 0
              functioning pituitary adenoma + 19
              functionless pituitary adenoma 0
              pituitary adenoma 1 1
              pituitary adenoma 3 2
              pituitary adenoma 5 5
Path 2
Term Annotations click to browse term
  disease 16109
    disease of anatomical entity 15665
      nervous system disease 13531
        Nervous System Neoplasms 1622
          Central Nervous System Neoplasms 1431
            central nervous system cancer 781
              brain cancer 765
                supratentorial cancer 492
                  diencephalic neoplasm 40
                    hypothalamic neoplasm 40
                      Pituitary Neoplasms 38
                        pituitary gland benign neoplasm 25
                          pituitary adenoma 25
                            acidophil adenoma 0
                            basophil adenoma 0
                            chromophobe adenoma 0
                            functioning pituitary adenoma + 19
                            functionless pituitary adenoma 0
                            pituitary adenoma 1 1
                            pituitary adenoma 3 2
                            pituitary adenoma 5 5
paths to the root