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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ofloxacin
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Accession:CHEBI:7731 term browser browse the term
Definition:A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Synonyms:exact_synonym: rac-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
 related_synonym: (3RS)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;   DL 8280;   Exocin;   Floxin;   Formula=C18H20FN3O4;   Gailuoxian;   HOE-280;   OFLX;   ORF 18489;   Ocuflox;   Oxaldin;   Prifloxcin;   Prifloxin;   Tarivid;   Visiren;   ofloxacine;   ofloxacino;   ofloxacinum;   rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid;   rac-ofloxacin;   racemic ofloxacin
 alt_id: CHEBI:100146
 xref: CAS:82419-36-1;   DrugBank:DB01165;   Drug_Central:1981;   HMDB:HMDB0015296;   KEGG:C07321;   KEGG:D00453;   LINCS:LSM-4370
 xref_mesh: MESH:D015242
 xref: MetaCyc:CPD-12843;   PMID:11710934;   PMID:11903499;   PMID:12827054;   PMID:15008519;   PMID:15557076;   PMID:16669862;   PMID:1804789;   PMID:19646516;   PMID:24497308;   PMID:24550337;   PMID:3469159;   PMID:3546152;   PMID:35897550;   PMID:36004580;   PMID:36228398;   PMID:36268299;   PMID:6960805;   PMID:7884650;   PMID:9228220;   Reaxys:3657947;   VSDB:1898;   Wikipedia:Ofloxacin


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ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Ofloxacin results in decreased activity of ABCB11 protein
Ofloxacin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Ofloxacin affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Ofloxacin results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] CTD PMID:11408986 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] CTD PMID:11408986 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Ofloxacin results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] CTD PMID:16148020 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ins1 insulin 1 increases expression EXP Ofloxacin results in increased expression of INS1 protein CTD PMID:17026994 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Ofloxacin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Ofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression		 ISO Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Ofloxacin results in decreased expression of MMP13 mRNA		 CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Ofloxacin results in increased expression of MMP3 mRNA CTD PMID:20688128 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ofloxacin results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Ofloxacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression ISO Ofloxacin results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Ofloxacin results in increased expression of PLAUR mRNA CTD PMID:20688128 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ofloxacin results in increased expression of PTGS2 mRNA CTD PMID:20688128 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Ofloxacin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO
EXP		 Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects localization
decreases expression		 ISO Ofloxacin affects the localization of SLC2A1 mRNA
Ofloxacin results in decreased expression of SLC2A1 mRNA		 CTD PMID:19022360 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Ofloxacin results in increased expression of TNFRSF12A mRNA CTD PMID:20688128 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    chemical entity 19836
      chemical substance 14402
        mixture 13719
          racemate 12095
            ofloxacin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    main group molecular entity 19786
                      s-block molecular entity 19624
                        hydrogen molecular entity 19611
                          hydrides 19117
                            inorganic hydride 18115
                              pnictogen hydride 18104
                                nitrogen hydride 18011
                                  azane 17821
                                    ammonia 17820
                                      organic amino compound 17820
                                        tertiary amino compound 10141
                                          N-alkylpiperazine 3397
                                            N-methylpiperazine 1386
                                              9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid 204
                                                levofloxacin 204
                                                  ofloxacin 24
paths to the root