CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: geneticin
Accession: CHEBI:42768
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Definition: An aminoglycoside antibiotic produced by Micromonospora rhodorangea. It blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
Synonyms: exact_synonym: (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside
related_synonym: Formula=C20H40N4O10; G 418; G418; InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6?,7-,8+,9+,10+,11-,12-,13+,14+,15+,16-,17+,18+,19+,20-/m0/s1; InChIKey=BRZYSWJRSDMWLG-CAXSIQPQSA-N; SMILES=CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]1[C@H](N)C[C@H](N)[C@@H](O[C@H]2O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]2N)[C@@H]1O; antibiotic G 418
alt_id: CHEBI:33028; CHEBI:42764
xref: Beilstein:1669188; CAS:49863-47-0; DrugBank:DB04263; KEGG:C17703
xref_mesh: MESH:C010680
xref: PDBeChem:GET
cyclic_relationship: is_conjugate_base_of CHEBI:195256
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases expression increases transport
ISO
antibiotic G 418 results in decreased expression of ABCB1 mRNA ABCB1 protein results in increased transport of antibiotic G 418
CTD
PMID:20018165
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcc1
ATP binding cassette subfamily C member 1
increases transport
ISO
ABCC1 protein results in increased transport of antibiotic G 418
CTD
PMID:20018165
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
G
Abcc2
ATP binding cassette subfamily C member 2
increases transport
ISO
ABCC2 protein results in increased transport of antibiotic G 418
CTD
PMID:20018165
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
G
Abcc3
ATP binding cassette subfamily C member 3
increases transport
ISO
ABCC3 protein results in increased transport of antibiotic G 418
CTD
PMID:20018165
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
G
Atm
ATM serine/threonine kinase
increases expression
ISO
antibiotic G 418 results in increased expression of ATM protein mutant form
CTD
PMID:15498871
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
G
Avpr2
arginine vasopressin receptor 2
multiple interactions
ISO
antibiotic G 418 results in increased expression of and results in increased activity of AVPR2 protein mutant form
CTD
PMID:12414899 PMID:14998935
NCBI chr X:151,633,501...151,636,155
Ensembl chr X:151,633,522...151,635,989
G
Capn2
calpain 2
increases cleavage
ISO
antibiotic G 418 results in increased cleavage of CAPN2 protein
CTD
PMID:15241557
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
G
Casp12
caspase 12
increases cleavage
ISO
antibiotic G 418 results in increased cleavage of CASP12 protein
CTD
PMID:15241557
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
G
Casp3
caspase 3
increases activity
ISO
antibiotic G 418 results in increased activity of CASP3 protein
CTD
PMID:15241557
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
increases activity multiple interactions
ISO
antibiotic G 418 results in increased activity of CASP9 protein benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [antibiotic G 418 results in increased activity of CASP9 protein]
CTD
PMID:15241557
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cftr
CF transmembrane conductance regulator
increases expression
ISO
antibiotic G 418 results in increased expression of CFTR protein mutant form
CTD
PMID:17541014
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
F7
coagulation factor VII
multiple interactions
ISO
antibiotic G 418 results in increased expression of and results in increased activity of F7 protein
CTD
PMID:16706976
NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
G
Gpx1
glutathione peroxidase 1
affects localization
ISO
antibiotic G 418 affects the localization of GPX1 mRNA mutant form
CTD
PMID:28743738
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Hsf1
heat shock transcription factor 1
increases activity
ISO
antibiotic G 418 results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
G
Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
increases expression
ISO
antibiotic G 418 results in increased expression of KCNJ1 protein mutant form
CTD
PMID:12911542
NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796
G
Mmut
methylmalonyl-CoA mutase
affects expression multiple interactions
ISO
antibiotic G 418 affects the expression of MMUT mRNA mutant form [antibiotic G 418 co-treated with Gentamicins] affects the activity of MMUT protein mutant form; [antibiotic G 418 co-treated with Gentamicins] affects the expression of MMUT mRNA mutant form; antibiotic G 418 promotes the reaction [Gentamicins affects the expression of MMUT protein mutant form]
CTD
PMID:19427250
NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
G
Slc4a4
solute carrier family 4 member 4
increases expression
ISO
antibiotic G 418 results in increased expression of SLC4A4 protein mutant form
CTD
PMID:18614622
NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
G
Smn1
survival of motor neuron 1, telomeric
increases expression
ISO
antibiotic G 418 results in increased expression of SMN2 protein
CTD
PMID:19150990
NCBI chr 2:31,490,018...31,501,065
Ensembl chr 2:31,490,015...31,501,060
G
Upf1
UPF1, RNA helicase and ATPase
affects localization
ISO
antibiotic G 418 affects the localization of UPF1 protein
CTD
PMID:28743738
NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
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