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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:anagrelide
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Accession:CHEBI:142290 term browser browse the term
Definition:A 1,5-dihydroimidazo[2,1-]quinazoline having an oxo substituent at the 2-position and chloro substituents at the 6- and 7-positions.
Synonyms:exact_synonym: 6,7-dichloro-1,5-dihydroimidazo[2,1-]quinazolin-2(3H)-one
 related_synonym: Formula=C10H7Cl2N3O;   InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16);   InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N;   SMILES=Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl;   anagrelida;   anagrelidum
 xref: Beilstein:619582;   CAS:68475-42-3;   DrugBank:DB00261;   Drug_Central:209;   KEGG:D07455;   LINCS:LSM-3380
 xref_mesh: MESH:C021139
 xref: Wikipedia:Anagrelide


show annotations for term's descendants           Sort by:
anagrelide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fli1 Friend leukemia integration 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA] CTD PMID:20586925 NCBI chr 9:32,333,500...32,454,292
Ensembl chr 9:32,333,500...32,454,157 		JBrowse link
G Gata1 GATA binding protein 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein] CTD PMID:20586925 NCBI chr  X:7,825,504...7,842,844
Ensembl chr  X:7,825,499...7,844,310 		JBrowse link
G Itga2b integrin alpha 2b multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA] CTD PMID:20586925 NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948 		JBrowse link
G Mpl myeloproliferative leukemia virus oncogene multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA] CTD PMID:20586925 NCBI chr 4:118,299,609...118,314,771
Ensembl chr 4:118,299,612...118,314,710 		JBrowse link
G Nfe2 nuclear factor, erythroid derived 2 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA] CTD PMID:20586925 NCBI chr15:103,156,640...103,166,809
Ensembl chr15:103,156,639...103,166,830 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide increases expression ISO anagrelide results in increased expression of PDGFB mRNA CTD PMID:15682418 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO anagrelide results in decreased expression of TGFB1 mRNA CTD PMID:15682418 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thpo thrombopoietin multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein]; anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 NCBI chr16:20,543,204...20,553,261
Ensembl chr16:20,543,204...20,553,261 		JBrowse link
G Zfpm1 zinc finger protein, multitype 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 NCBI chr 8:123,008,595...123,064,601
Ensembl chr 8:123,008,880...123,063,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21764
        pharmaceutical 21179
          drug 21179
            cardiovascular drug 8898
              anagrelide 9
                anagrelide hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21921
                        carbon atom 21847
                          organic molecular entity 21847
                            organic molecule 21664
                              organic cyclic compound 21273
                                organic heterocyclic compound 20345
                                  organic heteropolycyclic compound 19634
                                    organic heterotricyclic compound 16298
                                      imidazoquinazoline 12
                                        anagrelide 9
                                          anagrelide hydrochloride 0
paths to the root