The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A racemate comprising equimolar amounts of (R)- and (S)-sulconazole. An antifungal agent with activity against Candida species, it is used (generally as the nitrate salt) for the topical treatment of fungal skin infections.
sulconazole results in increased expression of CYP2B6 mRNA [sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA
sulconazole results in increased expression of CYP3A4 mRNA [sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
sulconazole affects the localization of NR1I3 protein mutant form sulconazole binds to NR1I3 protein [sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; sulconazole binds to and results in increased activity of NR1I3 protein alternative form; sulconazole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
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