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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:norwogonin
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Accession:CHEBI:7642 term browser browse the term
Definition:A trihydroxyflavone with the hydroxy groups at positions C-5, -7 and -8.
Synonyms:exact_synonym: 5,7,8-trihydroxy-2-phenyl-4H-chromen-4-one
 related_synonym: 2-Phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one;   5,7,8-Trihydroxyflavone;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H;   InChIKey=ZFKKRRMUPBBYRS-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(oc(cc2=O)-c2ccccc2)c1O
 xref: Beilstein:272168;   CAS:4443-09-8;   KEGG:C10113;   KNApSAcK:C00001077;   LIPID_MAPS_instance:LMPK12111329
 xref_mesh: MESH:C055505
 xref: PMID:12494330;   PMID:15563763;   PMID:17252377;   PMID:3281825;   PMID:8117326;   Reaxys:272168


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norwogonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO norwogonin analog results in increased expression of ADIPOQ protein; norwogonin results in increased expression of ADIPOQ protein CTD PMID:30445784 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]
norwogonin results in increased expression of BAX protein		 CTD PMID:32862589 PMID:33413359 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 norwogonin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]
norwogonin results in decreased expression of BCL2 protein		 CTD PMID:32862589 PMID:33413359 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 mRNA] CTD PMID:33413359 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein] CTD PMID:33413359 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO norwogonin results in decreased expression of CCNB1 protein CTD PMID:32862589 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO norwogonin analog results in increased expression of CEBPA protein; norwogonin results in increased expression of CEBPA protein CTD PMID:30445784 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of CYCS mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein] CTD PMID:33413359 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO norwogonin results in increased expression of CYP1A1 protein CTD PMID:37515497 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:33413359 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Ins1 insulin 1 increases secretion EXP norwogonin analog results in increased secretion of INS1 protein CTD PMID:30445784 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 increases response to substance ISO norwogonin results in increased susceptibility to INS protein CTD PMID:28854906 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Lep leptin decreases expression ISO norwogonin analog results in decreased expression of LEP protein; norwogonin results in decreased expression of LEP protein CTD PMID:30445784 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO norwogonin analog results in decreased expression of RBP4 protein; norwogonin results in decreased expression of RBP4 protein CTD PMID:30445784 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO norwogonin analog results in decreased expression of TNF protein; norwogonin results in decreased expression of TNF protein CTD PMID:30445784 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:33413359 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      chemical role 19420
        antioxidant 16122
          norwogonin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  oxacycle 17866
                                    benzopyran 11952
                                      1-benzopyran 11704
                                        flavonoid 7190
                                          anthoxanthin 4540
                                            flavones 4540
                                              hydroxyflavone 4518
                                                trihydroxyflavone 429
                                                  norwogonin 16
paths to the root