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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:deferiprone
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Accession:CHEBI:68554 term browser browse the term
Definition:A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Synonyms:exact_synonym: 3-hydroxy-1,2-dimethylpyridin-4(1H)-one
 related_synonym: 1,2-Dimethyl-3-hydroxypyrid-4-one;   3-Hydroxy-1,2-dimethyl-4(1H)-pyridone;   Ferriprox;   Formula=C7H9NO2;   InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3;   InChIKey=TZXKOCQBRNJULO-UHFFFAOYSA-N;   SMILES=Cc1c(O)c(=O)ccn1C
 xref: Beilstein:1447108;   CAS:30652-11-0;   Drug_Central:4188;   KEGG:D07416;   LINCS:LSM-36972
 xref_mesh: MESH:C044919
 xref: PMID:21853518;   PMID:22025507;   PMID:22034002;   PMID:22130677;   PMID:22171759;   PMID:22180427;   PMID:22277065;   PMID:22354281;   PMID:22406440;   PMID:22454828;   PMID:22457166;   PMID:22459459;   PMID:22468647;   PMID:22565013;   PMID:22572843;   PMID:22579919;   PMID:22621771;   PMID:22622672;   PMID:22664119;   PMID:22759897;   PMID:22850524;   PMID:22943064;   PMID:22978744;   Reaxys:1447108;   Wikipedia:Deferiprone


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deferiprone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein] CTD PMID:17172471 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:33285147 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein] CTD PMID:33285147 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein] CTD PMID:33285147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]		 CTD PMID:14576080 PMID:25813056 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP
ISO		 deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein]		 CTD PMID:17172471 PMID:33285147 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions EXP
ISO		 Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]		 CTD PMID:32937103 PMID:33285147 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Fxn frataxin increases expression ISO deferiprone results in increased expression of FXN mRNA; deferiprone results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO		 Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]		 CTD PMID:17172471 PMID:33285147 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO		 deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]		 CTD PMID:17172471 PMID:33285147 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein] CTD PMID:33285147 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein] CTD PMID:33285147 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP deferiprone inhibits the reaction [Doxorubicin results in decreased activity of SOD1 protein] CTD PMID:17007740 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tf transferrin increases expression
decreases uptake		 ISO deferiprone results in increased expression of TF mRNA; deferiprone results in increased expression of TF protein
deferiprone results in decreased uptake of TF protein		 CTD PMID:9763218 PMID:10865941 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:14576080 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      chemical role 19420
        ligand 6728
          chelator 6715
            iron chelator 1274
              deferiprone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteromonocyclic compound 17773
                                    pyridines 11511
                                      pyridone 152
                                        4-pyridones 35
                                          deferiprone 19
paths to the root