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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:triciribine
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Accession:CHEBI:65310 term browser browse the term
Definition:A nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage.
Synonyms:exact_synonym: 5-methyl-1-(beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
 related_synonym: Formula=C13H16N6O4;   InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1;   InChIKey=HOGVTUZUJGHKPL-HTVVRFAVSA-N;   SMILES=Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c3ncnc1c23;   TCN
 xref: CAS:35943-35-2;   LINCS:LSM-3810
 xref_mesh: MESH:C023764
 xref: PMID:22075556;   PMID:22728437;   PMID:22773664;   Reaxys:1171593


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triciribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO triciribine results in decreased phosphorylation of AKT1 protein CTD PMID:20857426 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation ISO triciribine results in decreased phosphorylation of AKT2 protein CTD PMID:20857426 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO triciribine inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]] CTD PMID:22178905 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]
triciribine results in increased expression of CASP3 mRNA		 CTD PMID:29117515 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA] CTD PMID:19961161 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases activity ISO triciribine results in decreased activity of FSHB protein CTD PMID:23254195 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO triciribine results in increased expression of H2AX mRNA CTD PMID:29117515 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO triciribine inhibits the reaction [HRAS protein results in increased activity of MMP2 protein] CTD PMID:23877152 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO triciribine inhibits the reaction [INS protein results in decreased susceptibility to sodium arsenite] CTD PMID:25982963 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO triciribine inhibits the reaction [HRAS protein results in increased activity of MMP2 protein] CTD PMID:23877152 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:24462917 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression		 ISO triciribine inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA]
triciribine results in increased expression of PARP1 mRNA		 CTD PMID:29117515 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Phb1 prohibitin 1 increases expression EXP triciribine results in increased expression of PHB1 protein CTD PMID:23254195 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein] CTD PMID:24462917 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        inhibitor 18877
          enzyme inhibitor 18704
            EC 2.* (transferase) inhibitor 14863
              EC 2.7.* (P-containing group transferase) inhibitor 14360
                lipid kinase inhibitor 1028
                  EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor 879
                    triciribine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbohydrates and carbohydrate derivatives 15270
                                    carbohydrate 15270
                                      carbohydrate derivative 14278
                                        glycosyl compound 13035
                                          N-glycosyl compound 5806
                                            nucleoside analogue 954
                                              triciribine 14
paths to the root