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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:moxifloxacin
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Accession:CHEBI:63611 term browser browse the term
Definition:A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.
Synonyms:exact_synonym: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid;   Formula=C21H24FN3O4;   InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1;   InChIKey=FABPRXSRWADJSP-MEDUHNTESA-N;   SMILES=[H][C@@]12CCCN[C@]1([H])CN(C2)c1c(F)cc2c(c1OC)n(cc(C(O)=O)c2=O)C1CC1
 alt_id: CHEBI:7007
 xref: CAS:151096-09-2;   DrugBank:DB00218;   Drug_Central:1854;   KEGG:C07663;   KEGG:D08237;   LINCS:LSM-5746
 xref_mesh: MESH:C104727
 xref: Patent:EP550903;   Reaxys:8365827;   VSDB:2983;   Wikipedia:Moxifloxacin
 cyclic_relationship: is_conjugate_base_of CHEBI:63699


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moxifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression ISO moxifloxacin results in decreased expression of IFNG protein CTD PMID:16006447 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO moxifloxacin results in decreased secretion of IL1B protein CTD PMID:16352735 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 decreases expression ISO moxifloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO moxifloxacin results in decreased activity of KCNH2 protein CTD PMID:24052561 PMID:27553911 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK1 protein CTD PMID:16352735 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK3 protein CTD PMID:16352735 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases secretion
decreases secretion		 ISO Moxifloxacin results in increased secretion of MMP1 protein
Moxifloxacin results in decreased secretion of MMP1 protein		 CTD PMID:24890593 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression		 EXP Moxifloxacin results in increased activity of MMP2 protein
Moxifloxacin results in increased expression of MMP2 mRNA		 CTD PMID:21058936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases secretion
increases secretion		 ISO Moxifloxacin results in decreased secretion of MMP3 protein
Moxifloxacin results in increased secretion of MMP3 protein		 CTD PMID:24890593 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion
increases expression
increases activity		 ISO
EXP		 Moxifloxacin results in decreased secretion of MMP9 protein
Moxifloxacin results in increased expression of MMP9 mRNA
Moxifloxacin results in increased activity of MMP9 protein		 CTD PMID:21058936 PMID:24890593 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Moxifloxacin results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO moxifloxacin results in decreased expression of RELA protein CTD PMID:16352735 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO moxifloxacin results in decreased secretion of TNF protein CTD PMID:16352735 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          quinolone antibiotic 2089
            moxifloxacin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      aromatic carboxylic acid 12618
                                        quinolinemonocarboxylic acid 107
                                          moxifloxacin 17
paths to the root