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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Ginkgoic acid
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Accession:CHEBI:5354 term browser browse the term
Definition:A hydroxybenzoic acid that has formula C22H34O3.
Synonyms:related_synonym: Formula=C22H34O3;   Ginkgolic acid;   InChI=1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-;   InChIKey=YXHVCZZLWZYHSA-FPLPWBNLSA-N;   SMILES=CCCCCC\\C=C/CCCCCCCc1cccc(O)c1C(O)=O
 xref: CAS:22910-60-7;   KEGG:C10794;   KNApSAcK:C00002651
 xref_mesh: MESH:C112485


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Ginkgoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [ginkgolic acid affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin CTD PMID:18204840 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of ACTA2 protein] CTD PMID:29524504 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions ISO ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of ACTA2 protein]; ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of and affects the localization of PIN1 protein]; ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of SUMO1 protein]; ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]; ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein]; ginkgolic acid inhibits the reaction [AGT protein modified form results in increased sumoylation of PML protein]; ginkgolic acid inhibits the reaction [PML protein promotes the reaction [AGT protein modified form results in increased expression of PIN1 protein]]; ginkgolic acid inhibits the reaction [PML protein promotes the reaction [AGT protein modified form results in increased expression of TGFB1 protein]]; PML protein inhibits the reaction [ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of PIN1 protein]]; PML protein inhibits the reaction [ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein]] CTD PMID:29524504 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Alb albumin affects expression EXP ginkgolic acid affects the expression of ALB protein CTD PMID:28564578 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ginkgoic acid increases expression of BAX mRNA and protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Ginkgoic acid decreases expression of BCL2 mRNA and protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Ginkgoic acid decreases expression of BCL2L1 mRNA and protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Ginkgoic acid increases cleavage of CASP3 protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Ginkgoic acid increases cleavage of CASP9 protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdh1 cadherin 1 increases expression
increases expression 		ISO ginkgolic acid results in increased expression of CDH1 protein
Ginkgoic acid increases expression of CDH1 protein in stomach		 CTD
RGD		 PMID:33508304 PMID:32106377 RGD:127284886 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Ginkgoic acid decreases expression of CDH2 protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Gpt glutamic--pyruvic transaminase affects expression EXP ginkgolic acid affects the expression of GPT protein CTD PMID:28564578 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
multiple interactions		 ISO ginkgolic acid results in decreased expression of IGF1R protein
ginkgolic acid affects the localization of and results in decreased sumoylation of IGF1R protein		 CTD PMID:33508304 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO ginkgolic acid inhibits the reaction [Tretinoin results in increased expression of ITGAM] CTD PMID:24819975 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Ginkgoic acid decreases phosphorylation of JAK2 protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases expression 		ISO ginkgolic acid results in decreased expression of MMP2 protein
Ginkgoic acid decreases expression of MMP2 protein in stomach		 CTD
RGD		 PMID:33508304 PMID:32106377 RGD:127284886 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Ginkgoic acid decreases expression of MMP9 protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 multiple interactions ISO ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of and affects the localization of PIN1 protein]; ginkgolic acid inhibits the reaction [PML protein promotes the reaction [AGT protein modified form results in increased expression of PIN1 protein]]; PML protein inhibits the reaction [ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of PIN1 protein]] CTD PMID:29524504 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Pml PML nuclear body scaffold decreases response to substance
multiple interactions		 ISO PML protein results in decreased susceptibility to ginkgolic acid
ginkgolic acid inhibits the reaction [AGT protein modified form results in increased sumoylation of PML protein]; ginkgolic acid inhibits the reaction [PML protein promotes the reaction [AGT protein modified form results in increased expression of PIN1 protein]]; ginkgolic acid inhibits the reaction [PML protein promotes the reaction [AGT protein modified form results in increased expression of TGFB1 protein]]; PML protein inhibits the reaction [ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of PIN1 protein]]; PML protein inhibits the reaction [ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein]]		 CTD PMID:29524504 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO Ginkgoic acid decreases expression of ROCK1 protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO ginkgolic acid inhibits the reaction [Tretinoin results in increased expression of RUNX2 mRNA] CTD PMID:24819975 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO ginkgolic acid results in decreased expression of SNAI2 protein CTD PMID:33508304 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO ginkgolic acid inhibits the reaction [Tretinoin results in increased expression of SP7 mRNA] CTD PMID:24819975 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO ginkgolic acid inhibits the reaction [Tretinoin results in increased expression of SPP1 mRNA] CTD PMID:24819975 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Ginkgoic acid decreases phosphorylation of STAT3 protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of SUMO1 protein] CTD PMID:29524504 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]; ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein]; ginkgolic acid inhibits the reaction [PML protein promotes the reaction [AGT protein modified form results in increased expression of TGFB1 protein]]; PML protein inhibits the reaction [ginkgolic acid inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein]] CTD PMID:29524504 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tjp1 tight junction protein 1 increases expression ISO Ginkgoic acid increases expression of TJP1 protein in stomach RGD PMID:32106377 RGD:127284886 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Vim vimentin decreases expression
decreases expression 		ISO ginkgolic acid results in decreased expression of VIM protein
Ginkgoic acid decreases expression of VIM protein in stomach		 CTD
RGD		 PMID:33508304 PMID:32106377 RGD:127284886 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          antifungal agent 16834
            salicylic acid 1542
              Ginkgoic acid 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      aromatic carboxylic acid 12598
                                        benzoic acids 12575
                                          benzoic acid 5327
                                            hydroxybenzoic acid 4794
                                              monohydroxybenzoic acid 2611
                                                salicylic acid 1542
                                                  Ginkgoic acid 29
paths to the root