Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Fexofenadine hydrochloride
go back to main search page
Accession:CHEBI:5051 term browser browse the term
Synonyms:related_synonym: Allegra (TN);   Formula=C32H39NO4.HCl;   Formula=C32H40ClNO4;   InChI=1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H;   InChIKey=RRJFVPUCXDGFJB-UHFFFAOYSA-N;   SMILES=C1=CC=CC(=C1)C(C=2C=CC=CC2)(C3CCN(CC3)CCCC(C4=CC=C(C=C4)C(C(O)=O)(C)C)O)O.Cl
 xref: CAS:138452-21-8;   CAS:153439-40-8;   KEGG:D00671
 xref_mesh: MESH:C093230


show annotations for term's descendants           Sort by:
Fexofenadine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases expression		 ISO
EXP		 Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine]
fexofenadine results in decreased expression of ABCB11 mRNA		 CTD PMID:18245269 PMID:24852568 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
multiple interactions
affects export		 ISO ABCB1 gene SNP affects the susceptibility to fexofenadine
Itraconazole promotes the reaction [ABCB1 gene SNP affects the susceptibility to fexofenadine]; Plant Extracts promotes the reaction [ABCB1 protein results in increased transport of fexofenadine]
ABCB1A protein affects the export of fexofenadine		 CTD PMID:12545142 PMID:15536457 PMID:15821041 PMID:16084853 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases export		 ISO [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of fexofenadine; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of fexofenadine
ABCC2 protein results in increased export of fexofenadine		 CTD PMID:18180276 PMID:18245269 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects transport
multiple interactions		 ISO ABCC3 protein affects the transport of fexofenadine
Adenosine Triphosphate promotes the reaction [ABCC3 protein affects the transport of fexofenadine]		 CTD PMID:18245269 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Apoe apolipoprotein E multiple interactions
decreases expression		 ISO [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of IL1A protein; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased abundance of Cholesterol, LDL; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of CCL3 protein; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA; [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA; APOE gene mutant form inhibits the reaction [fexofenadine results in decreased expression of MLXIPL mRNA]; APOE protein results in decreased susceptibility to [Dietary Fats co-treated with fexofenadine]
fexofenadine results in decreased expression of APOE mRNA		 CTD PMID:24852568 PMID:25020133 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 mRNA]; fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of CCL11 protein] CTD PMID:15460210 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO fexofenadine results in decreased expression of CCL17 mRNA; fexofenadine results in decreased expression of CCL17 protein CTD PMID:21109747 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 decreases expression ISO fexofenadine results in decreased expression of CCL22 mRNA; fexofenadine results in decreased expression of CCL22 protein CTD PMID:21109747 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of CCL3 protein CTD PMID:25020133 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:15460210 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein CTD PMID:25020133 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Ereg epiregulin decreases expression ISO fexofenadine results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]; fexofenadine inhibits the reaction [Histamine results in increased expression of GUSB protein] CTD PMID:11238657 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO fexofenadine binds to and results in decreased activity of HRH1 protein; fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein] CTD PMID:11238657 PMID:19652466 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO fexofenadine results in decreased expression of ICAM1 protein CTD PMID:16270723 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression		 ISO [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of IL1A protein
fexofenadine results in decreased expression of IL1A mRNA		 CTD PMID:25020133 PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO fexofenadine results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO fexofenadine inhibits the reaction [Histamine results in increased expression of IL6 protein] CTD PMID:11238657 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
increases activity		 ISO E 4031 inhibits the reaction [fexofenadine results in increased activity of KCNH2 protein mutant form]; fexofenadine inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein] CTD PMID:12070109 PMID:28521025 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO fexofenadine results in decreased phosphorylation of MAPK1 mRNA CTD PMID:21109747 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO fexofenadine results in decreased phosphorylation of MAPK3 mRNA CTD PMID:21109747 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO fexofenadine results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions
decreases expression		 ISO APOE gene mutant form inhibits the reaction [fexofenadine results in decreased expression of MLXIPL mRNA] CTD PMID:24852568 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO fexofenadine inhibits the reaction [TNF protein results in increased activity of MMP2 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; fexofenadine inhibits the reaction [TNF protein results in increased expression of MMP2 protein] CTD PMID:15663564 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO fexofenadine inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; fexofenadine inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:15663564 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO fexofenadine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15663564 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA; fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
fexofenadine results in decreased expression of NOS2 mRNA		 CTD PMID:17910814 PMID:25020133 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA CTD PMID:25020133 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [fexofenadine co-treated with Rifampin] results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO fexofenadine results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO fexofenadine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO fexofenadine inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15663564 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO fexofenadine results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases expression
multiple interactions
increases uptake		 ISO fexofenadine results in increased expression of SLCO1B2 mRNA
[SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of fexofenadine; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]		 CTD PMID:18180276 PMID:18245269 PMID:24852568 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO fexofenadine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO fexofenadine inhibits the reaction [TNF protein results in increased expression of TIMP1 protein] CTD PMID:15663564 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO fexofenadine inhibits the reaction [TNF protein results in increased expression of TIMP2 protein] CTD PMID:15663564 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fexofenadine inhibits the reaction [TNF protein results in increased activity of MMP2 protein]; fexofenadine inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; fexofenadine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; fexofenadine inhibits the reaction [TNF protein results in increased activity of RELA protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of MMP2 mRNA]; fexofenadine inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; fexofenadine inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of TIMP1 protein]; fexofenadine inhibits the reaction [TNF protein results in increased expression of TIMP2 protein] CTD PMID:15460210 PMID:15663564 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      group 19800
        polyatomic entity 19799
          molecule 19702
            cyclic compound 19516
              organic cyclic compound 19498
                organic aromatic compound 19366
                  diarylmethane 9439
                    Fexofenadine hydrochloride 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      p-block molecular entity 19792
                        carbon group molecular entity 19738
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                organic aromatic compound 19366
                                  diarylmethane 9439
                                    Fexofenadine hydrochloride 38
paths to the root