2-aminopurine - Ontology Report - Rat Genome Database

2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of ACP5 protein]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

Adgre1

adhesion G protein-coupled receptor E1

multiple interactions

2-Aminopurine affects the reaction [LEP protein affects the expression of ADGRE1 mRNA]

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

Atp6v0d2

ATPase H+ transporting V0 subunit D2

multiple interactions

2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 protein]

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

Calcr

calcitonin receptor

multiple interactions

2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of CALCR protein]

NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392

Ccl2

C-C motif chemokine ligand 2

multiple interactions

2-Aminopurine inhibits the reaction [LEP protein affects the expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

2-Aminopurine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; 2-Aminopurine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:1312672

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Eif2ak2

eukaryotic translation initiation factor 2-alpha kinase 2

decreases phosphorylation
multiple interactions
decreases activity

2-Aminopurine results in decreased phosphorylation of EIF2AK2 protein
2-Aminopurine inhibits the reaction [[IFNB1 results in increased expression of EIF2AK2 protein] which results in decreased susceptibility to Mercuric Chloride]
2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of EIF2AK2 protein]
2-Aminopurine results in decreased activity of EIF2AK2 protein

PMID:12890478 PMID:16324719 PMID:25739386

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

2-Aminopurine inhibits the reaction [TNF protein promotes the reaction [TNFSF11 protein results in increased expression of FOS protein]]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Ifnb1

interferon beta 1

multiple interactions

2-Aminopurine inhibits the reaction [[IFNB1 results in increased expression of EIF2AK2 protein] which results in decreased susceptibility to Mercuric Chloride]

PMID:16324719

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

Il6

interleukin 6

multiple interactions

2-Aminopurine affects the reaction [LEP protein affects the expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Lep

leptin

multiple interactions

2-Aminopurine affects the reaction [LEP protein affects the expression of ADGRE1 mRNA]; 2-Aminopurine affects the reaction [LEP protein affects the expression of IL6 mRNA]; 2-Aminopurine affects the reaction [LEP protein affects the expression of TNF mRNA]; 2-Aminopurine inhibits the reaction [LEP protein affects the expression of CCL2 mRNA]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

Mapk1

mitogen activated protein kinase 1

multiple interactions

2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

Mapk3

mitogen activated protein kinase 3

multiple interactions

2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Matk

megakaryocyte-associated tyrosine kinase

multiple interactions

2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of MATK protein]

NCBI chr 7:8,456,990...8,465,947
Ensembl chr 7:8,456,998...8,462,022

Nfatc1

nuclear factor of activated T-cells 1

multiple interactions

2-Aminopurine inhibits the reaction [TNF protein affects the localization of NFATC1 protein]; 2-Aminopurine inhibits the reaction [TNF protein promotes the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

Nfkb1

nuclear factor kappa B subunit 1

multiple interactions

2-Aminopurine inhibits the reaction [TNF protein affects the localization of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nfkbia

NFKB inhibitor alpha

multiple interactions

2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Rela

RELA proto-oncogene, NF-kB subunit

multiple interactions

2-Aminopurine inhibits the reaction [TNF protein affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Tnf

tumor necrosis factor

multiple interactions

2-Aminopurine affects the reaction [LEP protein affects the expression of TNF mRNA]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of ACP5 protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of CALCR protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of MATK protein]; 2-Aminopurine inhibits the reaction [TNF protein affects the localization of NFATC1 protein]; 2-Aminopurine inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; 2-Aminopurine inhibits the reaction [TNF protein affects the localization of RELA protein]; 2-Aminopurine inhibits the reaction [TNF protein promotes the reaction [TNFSF11 protein results in increased expression of FOS protein]]; 2-Aminopurine inhibits the reaction [TNF protein promotes the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of EIF2AK2 protein]; 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]

PMID:24150608 PMID:25739386

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfsf11

TNF superfamily member 11

multiple interactions

2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of ACP5 protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of CALCR protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of MATK protein]; 2-Aminopurine inhibits the reaction [TNF protein promotes the reaction [TNFSF11 protein results in increased expression of FOS protein]]; 2-Aminopurine inhibits the reaction [TNF protein promotes the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]