Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mometasone furoate
go back to main search page
Accession:CHEBI:47564 term browser browse the term
Definition:A 2-furoate ester that has formula C27H30Cl2O6.
Synonyms:exact_synonym: 9,21-dichloro-11beta-hydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate
 related_synonym: Formula=C27H30Cl2O6;   InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1;   InChIKey=WOFMFGQZHJDGCX-ZULDAHANSA-N;   SMILES=[H][C@@]12C[C@@H](C)[C@](OC(=O)c3ccco3)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   mometasone 17-furoate
 alt_id: CHEBI:6971
 xref: Beilstein:4340538;   CAS:83919-23-7;   DrugBank:DB00764;   Drug_Central:1832;   KEGG:D00690
 xref_mesh: MESH:C053915
 xref: PDBeChem:MOF;   Patent:EP57401;   Patent:US4472393;   Wikipedia:Mometasone


show annotations for term's descendants           Sort by:
mometasone furoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon] CTD PMID:16442095 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) multiple interactions
increases activity		 EXP Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mometasone Furoate results in increased activity of ABCG2 protein		 CTD PMID:16442095 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions EXP Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity EXP Mometasone Furoate results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Mometasone Furoate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G HSF1 heat shock transcription factor 1 increases activity EXP Mometasone Furoate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G IL10 interleukin 10 decreases secretion EXP Mometasone Furoate results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12B interleukin 12B multiple interactions EXP Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein] CTD PMID:19422381 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 affects binding ISO
EXP		 Mometasone Furoate binds to NR3C1 protein CTD PMID:16507850 PMID:19422381 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 affects binding EXP Mometasone Furoate binds to NR3C2 protein CTD PMID:19422381 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698 		JBrowse link
G PGR progesterone receptor multiple interactions
affects binding		 EXP Mometasone Furoate binds to and results in increased activity of PGR protein
Mometasone Furoate binds to PGR protein		 CTD PMID:15189034 PMID:19422381 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression ISO Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G TAT tyrosine aminotransferase increases activity EXP
ISO		 Mometasone Furoate results in increased activity of TAT protein CTD PMID:19422381 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092 		JBrowse link
G TGM2 transglutaminase 2 increases expression ISO Mometasone Furoate results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases secretion		 EXP Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Mometasone Furoate results in decreased secretion of TNF protein		 CTD PMID:9819297 PMID:10100995 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      application 25177
        anti-inflammatory agent 17792
          anti-inflammatory drug 15746
            mometasone furoate 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            heteroorganic entity 24770
                              organochalcogen compound 24383
                                organooxygen compound 24060
                                  carbonyl compound 23571
                                    ketone 19350
                                      oxo steroid 11046
                                        3-oxo steroid 10442
                                          3-oxo-Delta(4) steroid 9653
                                            progesterone 2907
                                              Delta(1)-progesterone 259
                                                mometasone 17
                                                  mometasone furoate 17
paths to the root