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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-hydroxycyclophosphamide
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Accession:CHEBI:1864 term browser browse the term
Definition:A phosphorodiamide that consists of 2-amino-1,3,2-oxazaphosphinan-4-ol 2-oxide having two 2-chloroethyl groups attached to the exocyclic nitrogen.
Synonyms:exact_synonym: 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphosphinan-4-ol 2-oxide
 related_synonym: Formula=C7H15Cl2N2O3P;   InChI=1S/C7H15Cl2N2O3P/c8-2-4-11(5-3-9)15(13)10-7(12)1-6-14-15/h7,12H,1-6H2,(H,10,13);   InChIKey=RANONBLIHMVXAJ-UHFFFAOYSA-N;   SMILES=OC1CCOP(=O)(N1)N(CCCl)CCCl;   Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
 xref: CAS:40277-05-2;   KEGG:C07643
 xref_mesh: MESH:C012358
 xref: Reaxys:526395;   Wikipedia:4-Hydroxycyclophosphamide


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4-hydroxycyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA CTD PMID:25833159 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of BDKRB2 mRNA CTD PMID:25833159 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Cd40 CD40 molecule multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA CTD PMID:25833159 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA CTD PMID:25833159 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL2RG mRNA CTD PMID:25833159 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Klk15 kallikrein-related peptidase 15 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of KLK15 mRNA CTD PMID:25833159 NCBI chr 1:94,699,422...94,706,626
Ensembl chr 1:94,703,158...94,706,329
Ensembl chr 1:94,703,158...94,706,329 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of MAPK14 mRNA CTD PMID:25833159 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            4-hydroxycyclophosphamide 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              oxoacid 18736
                                pnictogen oxoacid 13211
                                  phosphorus oxoacid 12414
                                    phosphoric acids 11418
                                      phosphoric acid 11418
                                        phosphoramide 1056
                                          phosphorodiamide 1005
                                            4-hydroxycyclophosphamide 10
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