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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-serine
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Accession:CHEBI:17115 term browser browse the term
Definition:The L-enantiomer of serine.
Synonyms:related_synonym: (2S)-2-amino-3-hydroxypropanoic acid;   (S)-2-amino-3-hydroxypropanoic acid;   (S)-alpha-Amino-beta-hydroxypropionic acid;   (S)-serine;   Formula=C3H7NO3;   InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1;   InChIKey=MTCFGRXMJLQNBG-REOHCLBHSA-N;   L-2-Amino-3-hydroxypropionic acid;   L-3-Hydroxy-2-aminopropionic acid;   L-3-Hydroxy-alanine;   L-Ser;   L-Serin;   S;   SERINE;   SMILES=N[C@@H](CO)C(O)=O;   Ser;   beta-Hydroxy-L-alanine;   beta-Hydroxyalanine
 alt_id: CHEBI:13167;   CHEBI:21387;   CHEBI:45440;   CHEBI:45451;   CHEBI:45590;   CHEBI:45597;   CHEBI:45677;   CHEBI:6301
 xref: Beilstein:1721404;   CAS:56-45-1;   DrugBank:DB00133;   Drug_Central:4127;   ECMDB:ECMDB00187;   Gmelin:2570;   HMDB:HMDB0000187;   KEGG:C00065;   KEGG:D00016;   KNApSAcK:C00001393
 xref_mesh: MESH:D012694
 xref: MetaCyc:SER;   PDBeChem:SER;   PMID:1650428;   PMID:17439666;   PMID:19062365;   PMID:21956576;   PMID:22265470;   PMID:22393170;   PMID:22547037;   PMID:22566084;   PMID:22566694;   Reaxys:1721404;   Wikipedia:L-serine;   YMDB:YMDB00112
 cyclic_relationship: is_conjugate_acid_of CHEBI:32836;   is_conjugate_base_of CHEBI:32837;   is_enantiomer_of CHEBI:16523;   is_tautomer_of CHEBI:33384


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L-serine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein] CTD PMID:30476904 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Serine results in increased expression of ATF4 mRNA CTD PMID:29098664 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Serine results in increased expression of ATF6 mRNA CTD PMID:29098664 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Atf6b activating transcription factor 6 beta increases expression ISO Serine results in increased expression of ATF6B mRNA CTD PMID:29098664 NCBI chr17:34,866,120...34,874,048
Ensembl chr17:34,866,120...34,874,048 		JBrowse link
G Atxn3 ataxin 3 increases expression ISO Serine results in increased expression of ATXN3 mRNA CTD PMID:29098664 NCBI chr12:101,885,160...101,928,139
Ensembl chr12:101,885,160...101,924,505 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO Serine results in increased expression of BAX mRNA CTD PMID:29098664 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Calr calreticulin increases expression ISO Serine results in increased expression of CALR mRNA CTD PMID:29098664 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Canx calnexin increases expression ISO Serine results in increased expression of CANX mRNA CTD PMID:29098664 NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500 		JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 increases expression ISO Serine results in increased expression of CCT4 mRNA CTD PMID:29098664 NCBI chr11:22,940,593...22,953,336
Ensembl chr11:22,940,519...22,953,780 		JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 increases expression ISO Serine results in increased expression of CCT7 mRNA CTD PMID:29098664 NCBI chr 6:85,428,487...85,445,459
Ensembl chr 6:85,428,496...85,445,457 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Serine results in decreased expression of CEBPB mRNA CTD PMID:29098664 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cs citrate synthase decreases activity ISO Serine analog results in decreased activity of CS protein CTD PMID:19733154 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Derl2 Der1-like domain family, member 2 increases expression ISO Serine results in increased expression of DERL2 mRNA CTD PMID:29098664 NCBI chr11:70,898,266...70,910,667
Ensembl chr11:70,897,990...70,910,667 		JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 increases expression ISO Serine results in increased expression of DNAJB2 mRNA CTD PMID:29098664 NCBI chr 1:75,213,039...75,222,336
Ensembl chr 1:75,213,050...75,222,336 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Serine results in increased expression of DNAJB9 mRNA CTD PMID:29098664 NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Serine results in increased expression of DNAJC3 mRNA CTD PMID:29098664 NCBI chr14:119,175,371...119,219,114
Ensembl chr14:119,175,388...119,219,109 		JBrowse link
G Dnajc4 DnaJ heat shock protein family (Hsp40) member C4 increases expression ISO Serine results in increased expression of DNAJC4 mRNA CTD PMID:29098664 NCBI chr19:6,965,279...6,969,954
Ensembl chr19:6,965,279...6,969,940 		JBrowse link
G Edem1 ER degradation enhancer, mannosidase alpha-like 1 increases expression ISO Serine results in increased expression of EDEM1 mRNA CTD PMID:29098664 NCBI chr 6:108,800,984...108,836,317
Ensembl chr 6:108,805,602...108,836,317 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Serine results in increased expression of EIF2A mRNA CTD PMID:29098664 NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922 		JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Serine results in increased expression of ERP44 mRNA CTD PMID:29098664 NCBI chr 4:48,190,711...48,279,635
Ensembl chr 4:48,193,323...48,279,558 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein] CTD PMID:30476904 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 increases expression ISO Serine results in increased expression of HERPUD1 mRNA CTD PMID:29098664 NCBI chr 8:95,113,057...95,121,999
Ensembl chr 8:95,113,066...95,122,005 		JBrowse link
G Hsf1 heat shock factor 1 increases activity ISO Serine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Hspa1b heat shock protein 1B decreases expression ISO Serine results in decreased expression of HSPA1B mRNA CTD PMID:29098664 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Hspa1l heat shock protein 1-like increases expression ISO Serine results in increased expression of HSPA1L mRNA CTD PMID:29098664 NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261 		JBrowse link
G Htra4 HtrA serine peptidase 4 decreases expression ISO Serine results in decreased expression of HTRA4 mRNA CTD PMID:29098664 NCBI chr 8:25,514,944...25,529,160
Ensembl chr 8:25,514,945...25,528,978 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein] CTD PMID:30476904 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Lamc1 laminin, gamma 1 multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr 1:153,094,668...153,208,532
Ensembl chr 1:153,094,668...153,208,532 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein] CTD PMID:30476904 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 decreases expression ISO Serine results in decreased expression of MAPK10 mRNA CTD PMID:29098664 NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G P4hb prolyl 4-hydroxylase, beta polypeptide increases expression ISO Serine results in increased expression of P4HB protein CTD PMID:28975502 NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A decreases expression ISO Serine results in decreased expression of PPP1R15A mRNA CTD PMID:29098664 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692 		JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein] CTD PMID:30476904 NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO Serine results in decreased expression of SREBF1 mRNA CTD PMID:29098664 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srr serine racemase multiple interactions ISO SRR protein results in increased abundance of and results in increased secretion of Serine analog CTD PMID:27387750 NCBI chr11:74,794,853...74,818,427
Ensembl chr11:74,797,185...74,816,774 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein] CTD PMID:30476904 NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 decreases expression ISO Serine results in decreased expression of UBE2G2 mRNA CTD PMID:29098664 NCBI chr10:77,458,155...77,481,824
Ensembl chr10:77,458,109...77,481,827 		JBrowse link
G Vcp valosin containing protein decreases expression ISO Serine results in decreased expression of VCP mRNA CTD PMID:29098664 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507 		JBrowse link
goralatide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme increases expression
decreases expression
multiple interactions		 EXP goralatide results in increased expression of ACE mRNA
goralatide results in decreased expression of ACE mRNA
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]		 CTD PMID:20096676 PMID:33007385 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] CTD PMID:33007385 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:31181250 PMID:33007385 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO		 ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]		 CTD PMID:31181250 PMID:33007385 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] CTD PMID:33007385 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 affects abundance
multiple interactions		 EXP BDKRB1 protein affects the abundance of goralatide
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide		 CTD PMID:20096676 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687 		JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Gli1 GLI-Kruppel family member GLI1 multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]		 CTD PMID:31181250 NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843 		JBrowse link
G Gli2 GLI-Kruppel family member GLI2 multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]		 CTD PMID:31181250 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349 		JBrowse link
G Gli3 GLI-Kruppel family member GLI3 multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]		 CTD PMID:31181250 NCBI chr13:15,638,308...15,904,611
Ensembl chr13:15,637,820...15,904,611 		JBrowse link
G Mas1 MAS1 oncogene multiple interactions EXP ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030 		JBrowse link
G Ptch1 patched 1 multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]		 CTD PMID:31181250 NCBI chr13:63,656,142...63,721,274
Ensembl chr13:63,656,142...63,721,412 		JBrowse link
G Shh sonic hedgehog multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]		 CTD PMID:31181250 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]		 CTD PMID:31181250 NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364 		JBrowse link
G Vim vimentin multiple interactions EXP goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
Phe-Ser term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 affects binding ISO phenylalanylserine analog binds to SLC15A1 protein CTD PMID:21147219 NCBI chr14:121,697,033...121,742,666
Ensembl chr14:121,697,033...121,742,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      application 21752
        fuel 11464
          methanol 3987
            hydroxymethyl group 65
              serine 65
                L-serine 57
                  Ala-Ala-Ser 0
                  Ala-Asn-Gln-Ser 0
                  Ala-Asp-Ser 0
                  Ala-Gly-Ser 0
                  Ala-Leu-Leu-Ser 0
                  Ala-Leu-Val-Ser 0
                  Ala-Met-Ser-Arg 0
                  Ala-Phe-Thr-Ser 0
                  Ala-Ser 0
                  Ala-Val-Asp-Ser 0
                  Arg-Asn-Gly-Ser 0
                  Arg-Asp-Gln-Ser 0
                  Arg-Trp-Ser-Tyr 0
                  Asn-Asn-Pro-Ser 0
                  Asn-Leu-Leu-Ser 0
                  Asn-Ser 0
                  Asn-Trp-Asp-Ser 0
                  Asp-Gln-Ser 0
                  Asp-Leu-Leu-Ser 0
                  Asp-Leu-Thr-Ser 0
                  Asp-Pro-Ser-Ser 0
                  Asp-Ser 0
                  Cys-Ser 0
                  Gln-Ser 0
                  Glu-Ile-Ser 0
                  Glu-Ser 0
                  Gly-Ser + 0
                  L-3-oxoalanine + 0
                  L-serine derivative + 0
                  L-serine residue + 0
                  L-serino group 0
                  L-seryl group 0
                  Leu-Ala-Ser 0
                  Leu-Asp-Ser 0
                  Leu-Gly-Ser 0
                  Leu-Leu-Ser 0
                  Leu-Ser 0
                  Leu-Ser-Ser-Tyr 0
                  Leu-Thr-Ser 0
                  Leu-Val-Ser 0
                  Lys-Leu-Ser 0
                  Lys-Ser-Trp 0
                  Met-Ser 0
                  N(2)-[3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoyl]-L-serinamide 0
                  N-arachidonoyl-L-serine 0
                  O-ureido-L-serine 0
                  Phe-Ser 1
                  Pro-Ser 0
                  Ser-Asp-Lys 0
                  Ser-Asp-Lys-Pro + 16
                  Ser-His 0
                  Ser-Leu-Ser 0
                  Ser-Lys 0
                  Ser-Phe 0
                  Ser-Ser 0
                  Ser-Thr 0
                  Ser-Trp 0
                  Ser-Trp-Lys 0
                  Ser-Tyr 0
                  Thr-Ala-Ser 0
                  Thr-Ser 0
                  Trp-Asp-Ser 0
                  Trp-Ser 0
                  Tyr-Ser 0
                  cryptomaldamide 0
                  lejimalide A 0
                  lejimalide B 0
                  vanchrobactin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    main group molecular entity 22108
                      s-block molecular entity 21708
                        hydrogen molecular entity 21626
                          hydrides 20762
                            inorganic hydride 18674
                              pnictogen hydride 18654
                                nitrogen hydride 18521
                                  azane 18428
                                    ammonia 18427
                                      organic amino compound 18427
                                        amino acid 16414
                                          alpha-amino acid 14209
                                            L-alpha-amino acid 13304
                                              serine family amino acid 5545
                                                L-serine 57
                                                  Ala-Ala-Ser 0
                                                  Ala-Asn-Gln-Ser 0
                                                  Ala-Asp-Ser 0
                                                  Ala-Gly-Ser 0
                                                  Ala-Leu-Leu-Ser 0
                                                  Ala-Leu-Val-Ser 0
                                                  Ala-Met-Ser-Arg 0
                                                  Ala-Phe-Thr-Ser 0
                                                  Ala-Ser 0
                                                  Ala-Val-Asp-Ser 0
                                                  Arg-Asn-Gly-Ser 0
                                                  Arg-Asp-Gln-Ser 0
                                                  Arg-Trp-Ser-Tyr 0
                                                  Asn-Asn-Pro-Ser 0
                                                  Asn-Leu-Leu-Ser 0
                                                  Asn-Ser 0
                                                  Asn-Trp-Asp-Ser 0
                                                  Asp-Gln-Ser 0
                                                  Asp-Leu-Leu-Ser 0
                                                  Asp-Leu-Thr-Ser 0
                                                  Asp-Pro-Ser-Ser 0
                                                  Asp-Ser 0
                                                  Cys-Ser 0
                                                  Gln-Ser 0
                                                  Glu-Ile-Ser 0
                                                  Glu-Ser 0
                                                  Gly-Ser + 0
                                                  L-3-oxoalanine + 0
                                                  L-serine derivative + 0
                                                  L-serine residue + 0
                                                  L-serino group 0
                                                  L-seryl group 0
                                                  Leu-Ala-Ser 0
                                                  Leu-Asp-Ser 0
                                                  Leu-Gly-Ser 0
                                                  Leu-Leu-Ser 0
                                                  Leu-Ser 0
                                                  Leu-Ser-Ser-Tyr 0
                                                  Leu-Thr-Ser 0
                                                  Leu-Val-Ser 0
                                                  Lys-Leu-Ser 0
                                                  Lys-Ser-Trp 0
                                                  Met-Ser 0
                                                  N(2)-[3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoyl]-L-serinamide 0
                                                  N-arachidonoyl-L-serine 0
                                                  O-ureido-L-serine 0
                                                  Phe-Ser 1
                                                  Pro-Ser 0
                                                  Ser-Asp-Lys 0
                                                  Ser-Asp-Lys-Pro + 16
                                                  Ser-His 0
                                                  Ser-Leu-Ser 0
                                                  Ser-Lys 0
                                                  Ser-Phe 0
                                                  Ser-Ser 0
                                                  Ser-Thr 0
                                                  Ser-Trp 0
                                                  Ser-Trp-Lys 0
                                                  Ser-Tyr 0
                                                  Thr-Ala-Ser 0
                                                  Thr-Ser 0
                                                  Trp-Asp-Ser 0
                                                  Trp-Ser 0
                                                  Tyr-Ser 0
                                                  cryptomaldamide 0
                                                  lejimalide A 0
                                                  lejimalide B 0
                                                  vanchrobactin 0
paths to the root