Ace (angiotensin I converting enzyme) - Rat Genome Database

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Gene: Ace (angiotensin I converting enzyme) Mus musculus
Analyze
Symbol: Ace
Name: angiotensin I converting enzyme (Ensembl:angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)
RGD ID: 10468
MGI Page MGI
Description: Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including angiotensin maturation; cell proliferation in bone marrow; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiotensin converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin-converting enzyme; AW208573; CD143; dipeptidyl carboxypeptidase I; dipeptidyl peptidase; kininase II; MGC117827
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)EnsemblGRCm39 Ensembl
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBIMGSCv36mm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (IEP)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Angiotensin I-Converting Enzyme, Benign Serum Increase  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (ISO)
Arteriovenous Fistula  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
bipolar disorder  (IEA)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
CAKUT  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chemical colitis  (IEP)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholestasis  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (ISO)
Congenital Hepatic Fibrosis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diastolic heart failure  (ISO)
diffuse cystic renal dysplasia  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Familial Cerebral Cavernous Malformation  (ISO)
familial mediterranean fever  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (ISO)
focal segmental glomerulosclerosis 1  (ISO)
gallbladder adenocarcinoma  (ISO)
Gaucher's disease  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
glycogen storage disease V  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis A  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxia  (ISO)
hypertension  (IMP,ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
in situ carcinoma  (IMP)
Insulin Resistance  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukemia  (ISO)
leukostasis  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (IEP)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (IAGP,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (IMP)
male infertility  (ISO)
Memory Disorders  (ISO)
Meningococcal Infections  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve disease  (ISO)
mitral valve prolapse  (ISO)
multiple myeloma  (ISO)
Mycobacterium Infections  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
ocular hypotension  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreatic cancer  (IMP)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (IMP,ISO)
Pleural Effusion  (ISO)
pneumonia  (ISO)
polycythemia  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Infant Diseases  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyelonephritis  (ISO)
Radiation Nephropathy  (ISO)
renal fibrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory system disease  (ISO)
Right Ventricular Hypertrophy  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Staphylococcal Infections  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
subacute sclerosing panencephalitis  (ISO)
substance-induced psychosis  (ISO)
Sudden Death  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
uveitis  (ISO)
Vascular System Injuries  (ISO)
Venous Thromboembolism  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Remodeling  (ISO)
viral pneumonia  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
(S,S,S)-nicotianamine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP)
14,15-EET  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-dihydroxybenzoic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
aminoguanidine  (EXP)
amitrole  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
Butralin  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
candesartan  (ISO)
cannabidiol  (ISO)
captan  (EXP)
captopril  (EXP,ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
cilazapril monohydrate  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
corticosterone  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
ethylenediaminetetraacetic acid  (ISO)
fenvalerate  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (EXP)
fructose  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glycidol  (ISO)
goralatide  (EXP)
GW 4064  (EXP)
herbimycin  (ISO)
hydralazine  (ISO)
hydrazines  (EXP)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
inulin  (EXP)
isoprenaline  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipoic acid  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithium chloride  (ISO)
losartan  (EXP,ISO)
lycopene  (ISO)
Magnolol  (ISO)
maneb  (EXP)
manganese(II) chloride  (ISO)
manidipine  (ISO)
metformin  (EXP)
methoxychlor  (ISO)
metoprolol  (ISO)
microcystin RR  (EXP)
mifepristone  (ISO)
monocrotaline  (ISO)
N(4)-hydroxycytidine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
Nandrolone decanoate  (ISO)
naringin  (ISO)
nicotianamine  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
NS-398  (ISO)
oleuropein  (ISO)
oltipraz  (EXP,ISO)
omapatrilat  (ISO)
ouabain  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perindopril  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pravastatin  (ISO)
pregabalin  (ISO)
proanthocyanidin  (ISO)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
raloxifene  (ISO)
ramipril  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rivastigmine  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
spironolactone  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trandolapril  (ISO)
tributylstannane  (EXP)
triclosan  (ISO)
triptonide  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta metabolic process  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
angiotensin maturation  (IDA,IMP,ISO)
angiotensin-activated signaling pathway  (IMP)
animal organ regeneration  (ISO)
arachidonic acid secretion  (ISO)
bradykinin catabolic process  (ISO)
cell proliferation in bone marrow  (IMP)
cellular response to aldosterone  (ISO)
cellular response to glucose stimulus  (ISO)
eating behavior  (ISO)
embryo development ending in birth or egg hatching  (ISO)
female pregnancy  (ISO)
heart contraction  (IMP)
hormone catabolic process  (IDA,ISO)
hormone metabolic process  (ISO)
kidney development  (IMP,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
male gonad development  (IMP,ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of gap junction assembly  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of glucose import  (ISO)
neutrophil mediated immunity  (IMP)
peptide catabolic process  (ISO)
peptide metabolic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of peptidyl-cysteine S-nitrosylation  (IMP)
positive regulation of systemic arterial blood pressure  (IBA,IMP,ISO)
positive regulation of vasoconstriction  (ISO)
post-transcriptional regulation of gene expression  (IMP)
proteolysis  (IEA)
regulation of angiotensin metabolic process  (ISO)
regulation of blood pressure  (IDA,IMP,ISO)
regulation of heart rate by cardiac conduction  (IMP)
regulation of hematopoietic stem cell proliferation  (IMP)
regulation of smooth muscle cell migration  (ISO)
regulation of synaptic plasticity  (IDA)
regulation of systemic arterial blood pressure by renin-angiotensin  (IBA,ISO)
response to dexamethasone  (ISO)
response to hypoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (IMP)
substance P catabolic process  (ISO)
vasoconstriction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiotensin I-converting enzyme activity  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating angiotensinogen level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal embryo size  (IEA)
abnormal epididymal fat pad morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal interleukin level  (IAGP)
abnormal kidney arterial blood vessel morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney corticomedullary boundary morphology  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal kidney medullary ray morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney papilla morphology  (IAGP)
abnormal kidney pelvis morphology  (IAGP)
abnormal kidney vasculature morphology  (IAGP)
abnormal renal artery morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal urine osmolality  (IAGP)
albuminuria  (IAGP)
atrial fibrillation  (IAGP)
decreased angiotensin I-converting enzyme activity  (IAGP)
decreased angiotensin II level  (IAGP)
decreased body weight  (IAGP)
decreased circulating angiotensin II level  (IAGP)
decreased circulating angiotensinogen level  (IAGP)
decreased fertilization frequency  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased hematocrit  (IAGP)
decreased insulin secretion  (IAGP)
decreased kidney weight  (IAGP)
decreased litter size  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased tumor growth/size  (IAGP)
decreased urine aldosterone level  (IAGP)
decreased urine osmolality  (IAGP)
dilated heart  (IAGP)
dilated kidney calyx  (IAGP)
dilated renal glomerular capsule  (IAGP)
embryonic growth retardation  (IEA)
hydronephrosis  (IAGP)
hyperactivity  (IEA)
hypotension  (IAGP)
impaired binding of sperm to zona pellucida  (IAGP)
impaired fertilization  (IAGP)
impaired sperm migration in female genital tract  (IAGP)
increased angiotensin I-converting enzyme activity  (IAGP)
increased basophil cell number  (IEA)
increased blood urea nitrogen level  (IAGP)
increased body weight  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating renin level  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased glomerular capsule space  (IAGP)
increased heart atrium size  (IAGP)
increased heart rate  (IAGP)
increased heart weight  (IAGP)
increased insulin secretion  (IAGP)
increased renin activity  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased T cell number  (IAGP)
increased urine potassium level  (IAGP)
kidney atrophy  (IAGP)
kidney cortex atrophy  (IAGP)
kidney cyst  (IAGP)
kidney inflammation  (IAGP)
kidney medulla atrophy  (IAGP)
kidney medulla cyst  (IAGP)
kidney medulla hypoplasia  (IAGP)
kidney papillary atrophy  (IAGP)
polyuria  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
reduced male fertility  (IAGP)
renal tubule atrophy  (IAGP)
tubulointerstitial nephritis  (IAGP)
vascular inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Protective effect of captopril against clozapine-induced myocarditis in rats: role of oxidative stress, proinflammatory cytokines and DNA damage. Abdel-Wahab BA, etal., Chem Biol Interact. 2014 Jun 5;216:43-52. doi: 10.1016/j.cbi.2014.03.012. Epub 2014 Apr 5.
2. Mechanisms of angiotensin converting enzyme inhibitor-induced IOP reduction in normotensive rats. Agarwal R, etal., Eur J Pharmacol. 2014 May 5;730:8-13. doi: 10.1016/j.ejphar.2014.02.021. Epub 2014 Feb 26.
3. Is serum angiotensin converting enzyme level a useful non-invasive marker for liver fibrosis in patients with chronic hepatitis C? Akar T, Rev Assoc Med Bras (1992). 2018 Mar;64(3):224-229. doi: 10.1590/1806-9282.64.03.224.
4. Elevated serum angiotensin converting enzyme levels as a reflection of bone marrow renin-angiotensin system activation in multiple myeloma. Albayrak M, etal., J Renin Angiotensin Aldosterone Syst. 2012 Jun;13(2):259-64. doi: 10.1177/1470320312437070. Epub 2012 Feb 16.
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146. Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14.
147. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
148. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
149. Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology. Qi Y, etal., Hypertension. 2013 Oct;62(4):746-52. doi: 10.1161/HYPERTENSIONAHA.113.01337. Epub 2013 Aug 19.
150. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases Qiu QM, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Apr;28(4):275-9.
151. Renin-angiotensin polymorphisms and QTc interval prolongation in end-stage renal disease. Raizada V, etal., Kidney Int. 2005 Sep;68(3):1186-9.
152. Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells. Ramos P, etal., Respir Res. 2014 Apr 28;15:54. doi: 10.1186/1465-9921-15-54.
153. [Angiotensin converting enzyme and left ventricular hypertrophy in uremic patients: correlation and therapeutic options]. Rasic S, etal., Acta Med Croatica. 2004;58(3):193-6.
154. Mouse MP Annotation Import Pipeline RGD automated import pipeline
155. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
156. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
157. Role of angiotensin II in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
158. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Rice GI, etal., Biochem J. 2004 Oct 1;383(Pt 1):45-51.
159. Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat. Riviere G, etal., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3.
160. Inhibitory effect of alphaS1- and alphaS2-casein hydrolysates on angiotensin I-converting enzyme in human endothelial cells in vitro, rat aortic tissue ex vivo, and renovascular hypertensive rats in vivo. Rousseau-Ralliard D, etal., J Dairy Sci. 2010 Jul;93(7):2906-21. doi: 10.3168/jds.2010-3060.
161. No significant correlation between ACE Ins/Del genetic polymorphism and COVID-19 infection. Saadat M, Clin Chem Lab Med. 2020 Jun 25;58(7):1127-1128. doi: 10.1515/cclm-2020-0577.
162. Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers. Sakuta T, etal., Arthritis Rheum. 2010 May;62(5):1319-28.
163. Local corticosterone production and angiotensin-I converting enzyme shedding in a mouse model of intestinal inflammation. Salmenkari H, etal., World J Gastroenterol. 2015 Sep 21;21(35):10072-9. doi: 10.3748/wjg.v21.i35.10072.
164. An experimental model of encapsulating peritoneal sclerosis. Sawada T, etal., Perit Dial Int. 2009 Feb;29 Suppl 2:S49-50.
165. Effects of imatinib mesylate on renin-angiotensin system (RAS) activity during the clinical course of chronic myeloid leukaemia. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
166. Angiotensin-converting enzyme (ACE) gene polymorphisms and familial occurrence of sarcoidosis. Schürmann M, etal., J Intern Med. 2001 Jan;249(1):77-83. doi: 10.1046/j.1365-2796.2001.00776.x.
167. Association of ACE and MTHFR genetic polymorphisms with type 2 diabetes mellitus: Susceptibility and complications. Settin A, etal., J Renin Angiotensin Aldosterone Syst. 2014 Jan 22.
168. Angiotensin converting enzyme (ACE) gene expression in experimentally induced liver cirrhosis in rats. Shahid SM, etal., Pak J Pharm Sci. 2013 Sep;26(5):853-7.
169. The ACE2/Ang-(1-7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension. Shenoy V, etal., Am J Respir Crit Care Med. 2010 Jun 25.
170. Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats. Shimizu H, etal., Hypertens Res. 2009 Sep;32(9):786-90. Epub 2009 Jul 10.
171. Preparation and antagonistic effect of ACE inhibitory peptide from cashew. Shu Y, etal., J Sci Food Agric. 2019 Dec;99(15):6822-6832. doi: 10.1002/jsfa.9967. Epub 2019 Sep 18.
172. Elevation of angiotensin-converting enzyme in granulomatous lymph nodes and serum in sarcoidosis: clinical and possible pathogenic significance. Silverstein E, etal., Ann N Y Acad Sci. 1976;278:498-513. doi: 10.1111/j.1749-6632.1976.tb47062.x.
173. Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibition. Spencer AU, etal., Dig Dis Sci. 2007 Apr;52(4):1060-70. doi: 10.1007/s10620-006-9124-2. Epub 2007 Mar 7.
174. Angiotensin I-Converting Enzyme Insertion/Deletion Polymorphism and Increased Risk of Gall Bladder Cancer in Women. Srivastava K, etal., DNA Cell Biol. 2010 May 3.
175. The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk. Staessen JA, etal., J Hypertens. 1997 Dec;15(12 Pt 2):1579-92.
176. Statins and Angiotensin-Converting Enzyme Inhibitors are Associated with Reduced Mortality and Morbidity in Chronic Liver Disease. Stokkeland K, etal., Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):104-110. doi: 10.1111/bcpt.12844. Epub 2017 Jul 30.
177. Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan. Sugimoto M, etal., Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1929-34. doi: 10.1158/1055-9965.EPI-06-0339.
178. ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. Sun HL, etal., Exp Clin Endocrinol Diabetes. 2009 Jul;117(7):336-44. Epub 2009 Mar 19.
179. Evaluation of the roles of the Leiden V mutation and ACE I/D polymorphism in subtypes of ischaemic stroke. Szolnoki Z, etal., J Neurol. 2001 Sep;248(9):756-61.
180. Angiotensin converting enzyme genotype affects development and course of sarcoidosis in Asian Indians. Tahir M, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2007 Sep;24(2):106-12.
181. Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. Tarnow L, etal., Diabetes. 1995 May;44(5):489-94.
182. The restoration of kidney mitochondria function by inhibition of angiotensin-II production in rats with acute adriamycin-induced nephrotoxicity. Taskin E, etal., Ren Fail. 2014 May;36(4):606-12. doi: 10.3109/0886022X.2014.882737. Epub 2014 Feb 6.
183. Angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms in children with subacute sclerosing panencephalitis. TaÅŸdemir N, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):445-8. doi: 10.1002/ajmg.b.30343.
184. Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models. Thoene-Reineke C, etal., PLoS One. 2011;6(8):e23646. Epub 2011 Aug 25.
185. Central angiotensin converting enzyme facilitates memory impairment in intracerebroventricular streptozotocin treated rats. Tota S, etal., Behav Brain Res. 2012 Jan 1;226(1):317-30. Epub 2011 Aug 16.
186. Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. Tseng CT, etal., J Virol. 2007 Feb;81(3):1162-73. Epub 2006 Nov 15.
187. Angiotensin-converting enzyme I/D polymorphism in Behcet's disease. Turgut S, etal., Med Princ Pract. 2005 Jul-Aug;14(4):213-6.
188. Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey. Turhan NK, etal., Genet Mol Res. 2015 Dec 16;14(4):17079-90. doi: 10.4238/2015.December.16.8.
189. Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia. Uma R, etal., J Matern Fetal Neonatal Med. 2010 Aug;23(8):874-9. doi: 10.3109/14767050903456667.
190. Upregulation of caveolin-1 expression is associated with structural modifications of endothelial cells in diabetic lung. Uyy E, etal., Microvasc Res. 2010 Mar;79(2):154-9. Epub 2010 Jan 6.
191. Angiotensin-converting enzyme (ACE) I/D corrected serum ACE activity and severity assessment of community-acquired pneumonia. van de Garde EM, etal., Clin Chem Lab Med. 2007;45(10):1326-31.
192. Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7.
193. Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat. Velkoska E, etal., Nutr Metab Cardiovasc Dis. 2010 Jan;20(1):49-55. Epub 2009 Apr 9.
194. Angiotensin I converting enzyme activity in adriamycin induced nephrosis in rats. Venkatesan N, etal., Toxicology. 1993 Dec 31;85(2-3):137-48.
195. Malaria infection promotes a selective expression of kinin receptors in murine liver. Ventura PDS, etal., Malar J. 2019 Jun 24;18(1):213. doi: 10.1186/s12936-019-2846-3.
196. [Role of angiotensin II type 1 receptor in activation of nuclear factor-kappaB and activator protein-1 in lung of mice with acute lung injury]. Wang F, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):113-6.
197. Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. Wang G, etal., Kidney Blood Press Res. 2011;34(3):141-9. doi: 10.1159/000324521. Epub 2011 Feb 24.
198. A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. Wang JL, etal., Kidney Int. 2000 Jun;57(6):2334-42.
199. [An experimental study of expression of angiotension converting enzyme 2 in myocardium and effect of telmisartan treatment in pressure-overloaded rats]. Wang LJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Apr;20(4):218-22.
200. Antiproteinuric effect predicts renal protection by angiotensin-converting enzyme inhibition in rats with established adriamycin nephrosis. Wapstra FH, etal., Clin Sci (Lond). 1996 May;90(5):393-401.
201. ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling. Watanabe H, etal., Heart Rhythm. 2009 Sep;6(9):1327-32. doi: 10.1016/j.hrthm.2009.05.014. Epub 2009 May 15.
202. Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss. Wei CC, etal., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29.
203. Angiotensin-converting enzyme in sarcoid uveitis. Weinreb RN, etal., Invest Ophthalmol Vis Sci. 1979 Dec;18(12):1285-7.
204. Renin-angiotensin system gene polymorphisms and diastolic heart failure. Wu CK, etal., Eur J Clin Invest. 2008 Nov;38(11):789-97. doi: 10.1111/j.1365-2362.2008.02017.x.
205. Demonstrating the pharmacogenetic effects of angiotensin-converting enzyme inhibitors on long-term prognosis of diastolic heart failure. Wu CK, etal., Pharmacogenomics J. 2010 Feb;10(1):46-53. doi: 10.1038/tpj.2009.39. Epub 2009 Sep 15.
206. Inhibition of AAA in a rat model by treatment with ACEI perindopril. Xiong F, etal., J Surg Res. 2014 Jun 1;189(1):166-73. doi: 10.1016/j.jss.2014.01.057. Epub 2014 Feb 5.
207. Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy. Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8.
208. Beneficial effects of beta-conglycinin on renal function and nephrin expression in early streptozotocin-induced diabetic nephropathy rats. Yang HY, etal., Br J Nutr. 2014 Jan 14;111(1):78-85. doi: 10.1017/S0007114513001876. Epub 2013 Jun 27.
209. Angiotensin-converting enzyme gene polymorphism is associated with anemia in non small-cell lung cancer. Yaren A, etal., Exp Biol Med (Maywood). 2008 Jan;233(1):32-7.
210. Angiotensin-converting enzyme inhibition promotes coronary angiogenesis in the failing heart of Dahl salt-sensitive hypertensive rats. Yazawa H, etal., J Card Fail. 2011 Dec;17(12):1041-50. Epub 2011 Oct 17.
211. Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis. Ye S, etal., Heart. 2003 Oct;89(10):1195-9.
212. The role of IL-4 gene 70 bp VNTR and ACE gene I/D variants in Familial Mediterranean fever. Yigit S, etal., Cytokine. 2014 May;67(1):1-6. doi: 10.1016/j.cyto.2014.01.007. Epub 2014 Feb 22.
213. Interdependent effect of angiotensin-converting enzyme and platelet-activating factor acetylhydrolase gene polymorphisms on the progression of immunoglobulin A nephropathy. Yoon HJ, etal., Clin Genet. 2002 Aug;62(2):128-34.
214. AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure. Yoshida J, etal., Hypertension. 2004 Mar;43(3):686-91. doi: 10.1161/01.HYP.0000118017.02160.fa. Epub 2004 Feb 2.
215. Interferon augments the anti-fibrotic activity of an angiotensin-converting enzyme inhibitor in patients with refractory chronic hepatitis C. Yoshiji H, etal., World J Gastroenterol. 2006 Nov 14;12(42):6786-91. doi: 10.3748/wjg.v12.i42.6786.
216. Deletion polymorphism of the angiotensin converting enzyme gene predicts persistent proteinuria in Henoch-Schonlein purpura nephritis. Yoshioka T, etal., Arch Dis Child. 1998 Nov;79(5):394-9.
217. Relationship between polymorphism of angiotensin-converting enzyme gene insertion/deletion and risk of hepatocellular carcinoma in a Chinese Dai population. Zha Y, etal., J Renin Angiotensin Aldosterone Syst. 2015 Sep;16(3):695-9. doi: 10.1177/1470320314539829. Epub 2014 Sep 10.
218. Interaction of angiotensin I-converting enzyme insertion-deletion polymorphism and daily salt intake influences hypertension in Japanese men. Zhang L, etal., Hypertens Res. 2006 Oct;29(10):751-8.
219. Association of angiotensin-converting enzyme gene I/D and CYP11B2 gene -344T/C polymorphisms with lone atrial fibrillation and its recurrence after catheter ablation. Zhang XL, etal., Exp Ther Med. 2012 Oct;4(4):741-747. Epub 2012 Jul 31.
220. Angiotensin-converting enzyme gene insertion/deletion polymorphism in children with Henoch-Schonlein purpua nephritis. Zhou J, etal., J Huazhong Univ Sci Technolog Med Sci. 2004;24(2):158-61.
Additional References at PubMed
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Genomics

Comparative Map Data
Ace
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)EnsemblGRCm39 Ensembl
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBIMGSCv36mm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
ACE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,477,061 - 63,498,380 (+)EnsemblGRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36Build 36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
T2T-CHM13v2.01764,347,269 - 64,368,872 (+)NCBIT2T-CHM13v2.0
Ace
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,410,129 - 91,430,246 (+)NCBIGRCr8
mRatBN7.21090,910,316 - 90,930,437 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1090,910,316 - 90,931,131 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1095,964,627 - 95,984,783 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,427,801 - 95,447,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,839,016 - 90,859,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
ACE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21979,648,057 - 79,669,151 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,465,633 - 84,486,649 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11762,710,398 - 62,724,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,702,341 - 62,733,853 (+)Ensemblpanpan1.1panPan2
ACE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,497,182 - 11,516,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,497,182 - 11,516,358 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,457,866 - 12,477,045 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,160,704 - 13,179,888 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,160,704 - 13,200,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,105,344 - 12,124,523 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,407,255 - 15,426,429 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,410,134 - 15,429,354 (-)NCBIUU_Cfam_GSD_1.0
LOC101968921
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560215,017,159 - 15,036,742 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,157,393 - 4,178,177 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,394,487 - 15,414,703 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,381,362 - 15,401,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ace
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624849998,277 - 1,019,521 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624849998,262 - 1,019,305 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ace
645 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1042
Count of miRNA genes:476
Interacting mature miRNAs:539
Transcripts:ENSMUST00000001963, ENSMUST00000001964, ENSMUST00000132280, ENSMUST00000151657
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102344123112384123Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103273992115021444Mouse

Markers in Region
AW208573  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,989,000 - 105,989,092UniSTSGRCm38
MGSCv3711105,850,314 - 105,850,406UniSTSGRCm37
Celera11117,720,546 - 117,720,638UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS
Whitehead/MRC_RH111424.74UniSTS
D11Mit13  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,975,635 - 105,975,795UniSTSGRCm38
MGSCv3711105,836,949 - 105,837,109UniSTSGRCm37
Celera11117,707,159 - 117,707,319UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS
Whitehead Genetic1165.6UniSTS
Whitehead_YAC11 UniSTS
D10Mit1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,975,635 - 105,975,795UniSTSGRCm38
MGSCv3711105,836,949 - 105,837,109UniSTSGRCm37
Celera11117,707,159 - 117,707,319UniSTS
Cytogenetic Map11E1UniSTS
cM Map103.0UniSTS
cM Map106.0UniSTS
cM Map1165.0UniSTS
Whitehead Genetic103.3UniSTS
Whitehead/MRC_RH10159.89UniSTS
D10Wox18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,975,646 - 105,975,785UniSTSGRCm38
MGSCv3711105,836,960 - 105,837,099UniSTSGRCm37
Celera11117,707,170 - 117,707,309UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS
Ace  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,989,113 - 105,989,238UniSTSGRCm38
MGSCv3711105,850,427 - 105,850,552UniSTSGRCm37
Celera11117,720,659 - 117,720,784UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001281819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_207624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK087056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY197083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY210311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001963   ⟹   ENSMUSP00000001963
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)Ensembl
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)Ensembl
RefSeq Acc Id: ENSMUST00000001964   ⟹   ENSMUSP00000001964
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,866,034 - 105,880,079 (+)Ensembl
GRCm38.p6 Ensembl11105,975,208 - 105,989,253 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132280   ⟹   ENSMUSP00000119826
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,862,149 - 105,880,086 (+)Ensembl
GRCm38.p6 Ensembl11105,971,323 - 105,989,260 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,867,431 - 105,875,939 (+)Ensembl
GRCm38.p6 Ensembl11105,976,605 - 105,985,113 (+)Ensembl
RefSeq Acc Id: NM_001281819   ⟹   NP_001268748
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,858,774 - 105,880,790 (+)NCBI
GRCm3811105,967,948 - 105,989,964 (+)NCBI
Celera11117,699,473 - 117,721,510 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009598   ⟹   NP_033728
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,866,015 - 105,880,790 (+)NCBI
GRCm3811105,975,189 - 105,989,964 (+)NCBI
MGSCv3711105,829,261 - 105,851,259 (+)RGD
Celera11117,699,473 - 117,721,510 (+)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_207624   ⟹   NP_997507
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,858,774 - 105,880,790 (+)NCBI
GRCm3811105,967,948 - 105,989,964 (+)NCBI
MGSCv3711105,829,261 - 105,851,259 (+)RGD
Celera11117,699,473 - 117,721,510 (+)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_997507   ⟸   NM_207624
- Peptide Label: isoform 1 precursor
- UniProtKB: P22967 (UniProtKB/Swiss-Prot),   Q6GTS2 (UniProtKB/Swiss-Prot),   P09470 (UniProtKB/Swiss-Prot),   Q3TU20 (UniProtKB/TrEMBL),   Q3U3Q7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_033728   ⟸   NM_009598
- Peptide Label: isoform 2 precursor
- UniProtKB: P09470 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001268748   ⟸   NM_001281819
- Peptide Label: isoform 3 precursor
- UniProtKB: Q5XK22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000119826   ⟸   ENSMUST00000132280
RefSeq Acc Id: ENSMUSP00000001963   ⟸   ENSMUST00000001963
RefSeq Acc Id: ENSMUSP00000001964   ⟸   ENSMUST00000001964
Protein Domains
Peptidase M2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
AF-P09470-F1-model_v2 AlphaFold P09470 1-1312 view protein structure  
ACE N-Terminal pdb 2c6f P09470 35-635 view protein structure  
ACE C-Terminal pdb 108a P09470 636-1237 view protein structure view video

Promoters
RGD ID:6820264
Promoter ID:MM_KWN:10200
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000006415,   UC007LXV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611105,829,191 - 105,829,691 (+)MPROMDB
RGD ID:6820263
Promoter ID:MM_KWN:10202
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000001964
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611105,835,741 - 105,836,492 (+)MPROMDB
RGD ID:6820265
Promoter ID:MM_KWN:10203
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000006418
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611105,836,731 - 105,837,231 (+)MPROMDB
RGD ID:8677042
Promoter ID:EPDNEW_M16552
Type:multiple initiation site
Name:Ace_1
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811105,967,948 - 105,968,008EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87874 AgrOrtholog
Ensembl Genes ENSMUSG00000020681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001963 ENTREZGENE
  ENSMUST00000001963.14 UniProtKB/Swiss-Prot
  ENSMUST00000001964 ENTREZGENE
  ENSMUST00000001964.8 UniProtKB/Swiss-Prot
  ENSMUST00000132280 ENTREZGENE
  ENSMUST00000132280.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1370.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11421 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87874 ENTREZGENE
NCBI Gene 11421 ENTREZGENE
PANTHER ANGIOTENSIN-CONVERTING ENZYME UniProtKB/Swiss-Prot
  ANGIOTENSIN-CONVERTING ENZYME UniProtKB/TrEMBL
  ANGIOTENSIN-CONVERTING ENZYME UniProtKB/TrEMBL
  PTHR10514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ACE RGD
PhenoGen Ace PhenoGen
PRINTS PEPDIPTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PEPTIDASE_M2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ACE_MOUSE UniProtKB/Swiss-Prot
  F6QCP8_MOUSE UniProtKB/TrEMBL
  P09470 ENTREZGENE
  P22967 ENTREZGENE
  Q3TU20 ENTREZGENE, UniProtKB/TrEMBL
  Q3U3Q7 ENTREZGENE, UniProtKB/TrEMBL
  Q5XK22 ENTREZGENE, UniProtKB/TrEMBL
  Q6GTS2 ENTREZGENE
  Q7TSV8_MOUSE UniProtKB/TrEMBL
  Q8C339_MOUSE UniProtKB/TrEMBL
  Q8K233_MOUSE UniProtKB/TrEMBL
UniProt Secondary P22967 UniProtKB/Swiss-Prot
  Q6GTS2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Ace  angiotensin I converting enzyme  Ace  angiotensin I converting enzyme (peptidyl-dipeptidase A) 1  Symbol and/or name change 5135510 APPROVED