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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diethyl 2-[(dimethoxyphosphoryl)thio]succinate
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Accession:CHEBI:141477 term browser browse the term
Definition:A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphoryl)thio group.
Synonyms:related_synonym: Formula=C10H19O7PS;   InChI=1S/C10H19O7PS/c1-5-16-9(11)7-8(10(12)17-6-2)19-18(13,14-3)15-4/h8H,5-7H2,1-4H3;   InChIKey=WSORODGWGUUOBO-UHFFFAOYSA-N;   SMILES=C(C(OCC)=O)C(C(OCC)=O)SP(OC)(OC)=O


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malaoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO
EXP		 [malaoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]
Dichlorvos promotes the reaction [malaoxon results in decreased activity of ACHE protein]; K075 compound inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]
malaoxon metabolite results in decreased activity of ACHE protein; malaoxon results in decreased activity of ACHE protein		 CTD PMID:597376 PMID:4859365 PMID:8783813 PMID:9268605 PMID:9515941 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Alb albumin affects binding ISO malaoxon binds to ALB protein CTD PMID:15525694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bche butyrylcholinesterase affects binding ISO malaoxon binds to BCHE protein; malaoxon binds to BCHE protein modified form CTD PMID:18514178 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO malaoxon results in increased expression of BCL2 mRNA CTD PMID:30673264 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cat catalase decreases expression ISO malaoxon results in decreased expression of CAT protein CTD PMID:30673264 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cldn5 claudin 5 multiple interactions
decreases expression		 EXP [malaoxon co-treated with Lead] results in decreased expression of CLDN5 protein
malaoxon results in decreased expression of CLDN5 protein		 CTD PMID:20970449 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion
multiple interactions		 ISO malaoxon results in increased secretion of GOT1 protein
[malaoxon co-treated with Obidoxime Chloride] results in increased secretion of GOT1 protein		 CTD PMID:36442613 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP malaoxon results in increased expression of HMOX1 protein CTD PMID:34778934 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ocln occludin multiple interactions
decreases expression		 EXP [malaoxon co-treated with Lead] results in decreased expression of OCLN protein
malaoxon results in decreased expression of OCLN protein		 CTD PMID:20970449 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity ISO malaoxon results in decreased activity of PNPLA6 protein CTD PMID:9268605 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO PON1 affects the susceptibility to [diazoxon co-treated with malaoxon]; PON1 affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate co-treated with malaoxon] CTD PMID:19371602 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO malaoxon results in increased expression of PTGS2 mRNA; malaoxon results in increased expression of PTGS2 protein CTD PMID:30673264 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO malaoxon results in increased expression of RELA mRNA CTD PMID:30673264 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation EXP malaoxon results in decreased phosphorylation of STAT3 protein CTD PMID:34778934 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression		 EXP [malaoxon co-treated with Lead] results in decreased expression of TJP1 protein
malaoxon results in decreased expression of TJP1 protein		 CTD PMID:20970449 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tjp2 tight junction protein 2 multiple interactions
decreases expression		 EXP [malaoxon co-treated with Lead] results in decreased expression of TJP2 protein
malaoxon results in decreased expression of TJP2 protein		 CTD PMID:20970449 NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP malaoxon results in increased expression of TRPC1 mRNA; malaoxon results in increased expression of TRPC1 protein CTD PMID:22674931 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 increases expression EXP malaoxon results in increased expression of TRPC4 mRNA; malaoxon results in increased expression of TRPC4 protein CTD PMID:22674931 NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          disinfectant 13874
            ethanol 8804
              ethyl ester 4135
                diethyl 2-[(dimethoxyphosphoryl)thio]succinate 18
                  (R)-malaoxon + 18
                  (S)-malaoxon + 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              oxoacid 18736
                                pnictogen oxoacid 13211
                                  phosphorus oxoacid 12414
                                    phosphoric acids 11418
                                      phosphoric acid 11418
                                        phosphoric acid derivative 11227
                                          phosphate 11226
                                            organic phosphate 11226
                                              organic thiophosphate 8613
                                                diethyl 2-[(dimethoxyphosphoryl)thio]succinate 18
                                                  (R)-malaoxon + 18
                                                  (S)-malaoxon + 18
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