Rat Strain Models for Neurological Diseases
Selected on the basis alcohol preference from the N/NIH Wistar rat. Ethanol preference and consumption scores were obtained. A free choice of water and 10% ethanol was provided. Amount of alcohol consumed was measured every 2-3 days for 3 weeks and the position of water and alcohol were reversed to avoid position effects.(REF RGD ID: 631212) These have greater genetic variability than P lines. Alcohol consumption of HAD1 males is 9.96 g/kg/day and of females is 11.10 g/kg/day. The ancestral Wistar lines were quite varied and were inbred thus may have fixed alcohol related traits.(REF RGD ID: 631230)
Selected on the basis alcohol preference from the N/NIH Wistar rat. Ethanol preference and consumption scores were obtained. A free choice of water and 10% ethanol was provided. Amount of alcohol consumed was measured every 2-3 days for 3 weeks and the position of water and alcohol were reversed to avoid position effects.(REF RGD ID: 631212) These have greater genetic variability than P lines.(REF RGD ID: 631230)
Selected on the basis alcohol preference from the N/NIH Wistar rat. Ethanol preference and consumption scores were obtained. A free choice of water and 10% ethanol was provided. Amount of alcohol consumed was measured every 2-3 days for 3 weeks and the position of water and alcohol were revered to avoid position effects.(REF RGD ID: 631212) These have greater genetic variability than NP lines. Alcohol consumption of LAD1 males is 0.14 g/kg/day and of females is 0.28 g/kg/day. The ancestral Wistar lines were quite varied and were inbred thus may have fixed alcohol related traits.(REF RGD ID: 631230)
Selected on the basis alcohol preference from the N/NIH Wistar rat. Ethanol preference and consumption scores were obtained. A free choice of water and 10% ethanol was provided. Amount of alcohol consumed was measured every 2-3 days for 3 weeks and the position of water and alcohol were revered to avoid position effects.(REF RGD ID: 631212) These have greater genetic variability than NP lines.(REF RGD ID: 631230)
High ethanol preferring line: Obtained by crossing male P and female SD rats (REF RGD ID:731213) High voluntary consumption of alcohol, high sensitivity to taste, high locomotor activity and low emotional activity. (All these are opposite to WKY rats) Females show higher consistency in alcohol consumption. (REF RGD ID:731213)
Alcohol preferring line developed at Indiana University; breeding was initiated after 30 generations of selection and 19 generations of breeding through bidirectional selective breeding from Wistar rats. Have high voluntary alcohol consumption, high blood alcohol concentration, consumption of alcohol for its pharmacological effects. These have lower serotonin 1b receptor and D2 receptor densities than the NP rats as these are attractive genes for alcohol preference so maybe involved in alcohol preference.(REF RGD ID:69704)Derived from a random breeding closed colony of Wistar rats which was from the Walter Reed Army Institute of Research, Washington, D.C. (REF RGD ID: 631230)
Alcohol non-preferring line developed at IndianaUniversity; breeding was initiated after 30 generations of selection and 19 generations of breeding through bidirectional selective breeding from Wistar rats.(REF RGD ID:69704) Derived from a random breeding closed colony of Wistar rats which was from the Walter Reed Army Institute of Research, Washington, D.C.(REF RGD ID: 631230)
Warsaw High Prefering: Derived from albino stock of Wistar; now in 27th generation. These were developed by assessing ethanol preference between 10% ethanol and water. Males and females with high preference were mated to develop the WHP line. (REF RGD ID: 1358540)
Warsaw Low Prefering: Derived from albino stock of Wistar; now in 27th generation. These were developed by assessing ethanol preference between 10% ethanol and water. Males and females with low preference were mated to develop the WLP line. (REF RGD ID: 1358540)
Susceptible to Multiple Scelerosis. Perivenous inflammation restricted to CNS associated with primary demyelination resulting in large confluent demyelinated plaques; higher serum levels of anti-MOG IgG, IgG2a, IgG2b, IgG2c than ACI/SegHsd (REF RGD ID: 69712). Develops paralysis with two to three relapses (REF RGD ID: 61031). Hemiparalysis, relapsing/remitting disease in ~70% in MOG induced disease (REF RGD ID: 1302437)
Susceptible to Multiple Scelerosis. High demyelination and inflammation indices with MOG induction, acute lethal 25%; monophasic 19%; relapsing/remitting 33%; primary progressive 6.3%, impaired balance 8.3% (REF RGD ID: 629629)
Resistant to Multiple Scelerosis. 1/21 showed demyelination with 50µg rMOG(aa 1-125) and spinal cord lesions (REF RGD ID: 69712).
Resistant to Multiple Scelerosis. 0/15 incident rate with spinal cord homogenate (REF RGD ID: 61031).
Resistant to active induction of EAE but susceptible to transferred EAE when injected with encephalitogenic T cells (REF RGD ID: 724738)
Resistant to Multiple Scelerosis. 4/61 incident rate with 20µg rMOG(aa 1-125)(REF RGD ID: 629629)
