RGD Reference Report - Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. - Rat Genome Database

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Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis.

Authors: Bergsteinsdottir, K  Yang, HT  Pettersson, U  Holmdahl, R 
Citation: Bergsteinsdottir K, etal., J Immunol 2000 Feb 1;164(3):1564-8
RGD ID: 61031
Web Url: http://www.jimmunol.org/cgi/content/abstract/164/3/1564
Pubmed: PMID:10640775   (View Abstract at PubMed)

The pathogenicity of multiple sclerosis is still poorly understood, but identification of susceptibility genes using the animal model experimental allergic encephalomyelitis (EAE) could provide leads. Certain genes may be shared between different autoimmune diseases, and identification of such genes is of obvious importance. To locate gene regions involved in the control of EAE and to compare the findings with the susceptibility loci recently identified in a model for rheumatoid arthritis (pristane-induced arthritis), we made crosses between the encephalomyelitis- and arthritis-susceptible rat strain DA and the resistant E3 strain. Genetic analysis of animals produced in a F2 intercross identified 11 loci associated with specific EAE-associated traits. Interestingly, five of these loci were situated at the same position as major loci controlling pristane-induced arthritis and showed similarities in inheritance pattern and subphenotype associations. Our results show that different phases of EAE are controlled by different sets of genes and that common genes are likely to be involved in different autoimmune diseases.



Disease Annotations    Click to see Annotation Detail View

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EaezRatabnormal inflammatory response  QTM  RGD 
Eae1Ratparesis  QTM  RGD 
Eae10Ratparesis  QTM  RGD 
Eae11Ratparesis  QTM  RGD 
Eae5Ratparesis  QTM  RGD 
Eae6Ratparesis  QTM  RGD 
Eae7Ratparesis  QTM  RGD 
Eae8Ratparesis  QTM  RGD 
Eae9Ratparesis  QTM  RGD 
EaexRatparesis  QTM  RGD 
EaeyRatparesis  QTM  RGD 
EaezRatparesis  QTM  RGD 

Objects Annotated

QTLs
Eae1  (Experimental allergic encephalomyelitis QTL 1)
Eae10  (Experimental allergic encephalomyelitis QTL 10)
Eae11  (Experimental allergic encephalomyelitis QTL 11)
Eae5  (Experimental allergic encephalomyelitis QTL 5)
Eae6  (Experimental allergic encephalomyelitis QTL 6)
Eae7  (Experimental allergic encephalomyelitis QTL 7)
Eae8  (Experimental allergic encephalomyelitis QTL 8)
Eae9  (Experimental allergic encephalomyelitis QTL 9)
Eaex  (Experimental allergic encephalomyelitis QTL x)
Eaey  (Experimental allergic encephalomyelitis QTL y)
Eaez  (Experimental allergic encephalomyelitis QTL z)

Strains
DA  (DA)
DA/Ztm  (NA)
E3  (NA)
E3/Ztm  (NA)

Objects referenced in this article
Marker D14Wox11 D14Wox11 Rattus norvegicus
Marker D18Wox13 D18Wox13 Rattus norvegicus
Marker D1Mgh12 D1Mgh12 Rattus norvegicus
Marker D1Mit13 D1Mit13 Rattus norvegicus
Marker D12Mit2 D12Mit2 Rattus norvegicus
Marker D4Wox30 D4Wox30 Rattus norvegicus
Marker D19Mit9 D19Mit9 Rattus norvegicus
Marker D14Mit6 D14Mit6 Rattus norvegicus
Marker D5Mit10 D5Mit10 Rattus norvegicus
Marker D1Mit7 D1Mit7 Rattus norvegicus
Marker D19Mit5 D19Mit5 Rattus norvegicus
Marker D6Mgh3 D6Mgh3 Rattus norvegicus
Marker D18Mgh1 D18Mgh1 Rattus norvegicus
Marker D20Mgh4 D20Mgh4 Rattus norvegicus
Marker D1Mgh9 D1Mgh9 Rattus norvegicus
Marker D4Mgh14 D4Mgh14 Rattus norvegicus
Marker D12Rat9 D12Rat9 Rattus norvegicus
Marker D6Rat10 D6Rat10 Rattus norvegicus
Marker D20Rat41 D20Rat41 Rattus norvegicus
Marker D5Wox21 D5Wox21 Rattus norvegicus
QTL Pia1 Pristane induced arthritis QTL 1 Rattus norvegicus
QTL Pia2 Pristane induced arthritis QTL 2 Rattus norvegicus
QTL Pia21 Pristane induced arthritis QTL 21 Rattus norvegicus
QTL Pia6 Pristane induced arthritis QTL 6 Rattus norvegicus

Additional Information