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Strain Registration

Strain: F344/DuCrl

Symbol: F344/DuCrl
Strain: F344
Substrain: DuCrl
RGD ID: 734478
Citation ID: RRID:RGD_734478
Ontology ID: RS:0000179
Also Known As: CDF/Crl, Strain Code 002; Fisher(CDF) Rat; CDF(F-344)/CrlBR
Type: inbred
Available Source: Charles River Laboratories
Origination: Charles River Laboratories
Description: This colony was originated by mating F344 rats which were purchased from local breeder(Fischer) by M.R. Curtis, Columbia University Institute for Cancer Research, 1920. Dunning at Columbia inbred to form the strain starting in 1920. Dunning to CRL in 1960 at F68. Caesarean rederived in 1960.
Coat Color: Albino
Last Known Status: Unknown
Portal(s): HRDP portal





Disease Annotations     Click to see Annotation Detail View
Toxemia  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
blood glucose level
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
arterial blood flow rate
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
blood insulin level
blood glucose level area under curve (AUC)
change in blood insulin level
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
serum globulin level

References

References - curated
# Reference Title Reference Citation
1. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat Galli J, etal., Nat Genet 1996 Jan;12(1):31-7
2. Mapping and confirmation of a major left ventricular mass QTL on rat chromosome 1 by contrasting SHRSP and F344 rats. Grabowski K, etal., Physiol Genomics. 2013 Sep 16;45(18):827-33. doi: 10.1152/physiolgenomics.00067.2013. Epub 2013 Jul 30.
3. Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. Newman ZL, etal., PLoS Pathog. 2010 May 20;6(5):e1000906. doi: 10.1371/journal.ppat.1000906.
4. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
5. PhysGen Strains PhysGen strains
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
Rnor_6.0 F344/DuCrl (2019) View Damaging Variants
mRatBN7.2 F344/DuCrl (2019) View Damaging Variants
mRatBN7.2 F344/DuCrl (2019NG) View Damaging Variants
mRatBN7.2 F344/DuCrl (2021) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease The blood pressure of females is 115 mmHg and of males is 112 mmHg. 629526
strain_other The average weight of females is 148g and of males 235g. 629526