RGD Reference Report - Mapping and confirmation of a major left ventricular mass QTL on rat chromosome 1 by contrasting SHRSP and F344 rats. - Rat Genome Database

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Mapping and confirmation of a major left ventricular mass QTL on rat chromosome 1 by contrasting SHRSP and F344 rats.

Authors: Grabowski, K  Koplin, G  Aliu, B  Schulte, L  Schulz, A  Kreutz, R 
Citation: Grabowski K, etal., Physiol Genomics. 2013 Sep 16;45(18):827-33. doi: 10.1152/physiolgenomics.00067.2013. Epub 2013 Jul 30.
RGD ID: 7771608
Pubmed: PMID:23901062   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00067.2013   (Journal Full-text)

An abnormal increase in left ventricular (LV) mass, i.e., LV hypertrophy (LVH), represents an important target organ damage in arterial hypertension and has been associated with poor clinical outcome. Genetic factors are contributing to variation in LV mass in addition to blood pressure and other factors such as dietary salt intake. We set out to map quantitative trait loci (QTL) for LV mass by comparing the spontaneously hypertensive stroke-prone (SHRSP) rat with LVH and normotensive Fischer rats (F344) with contrasting low LV mass. To this end we performed a genome-wide QTL mapping analysis in 232 F2 animals derived from SHRSP and F344 exposed to high-salt (4% in chow) intake for 8 wk. We mapped one major QTL for LV mass on rat chromosome 1 (RNO1) that demonstrated strong linkage (peak logarithm of odds score 8.4) to relative LV weight (RLVW) and accounted for approximately 19% of the variance of this phenotype in F2 rats. We therefore generated a consomic SHRSP-1(F344) strain in which RNO1 from F344 was introgressed into the SHRSP background. Consomic and SHRSP animals showed similar blood pressures during conventional intra-arterial measurements, while RLVW was already significantly lower (-17.7%, P<0.05) in SHRSP-1(F344) in response to a normal-salt diet; a similar significant reduction of LV mass was also observed in consomic rats after high-salt intake (P<0.05 vs. SHRSP). Thus, a major QTL on RNO1 was confirmed with significant impact on LV mass in the hypertensive background of SHRSP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IAGP 7771608 RGD 
hypertension susceptibilityIAGP 7771608compared to F344RGD 
Left Ventricular Hypertrophy susceptibilityIAGP 7771608compared to F344RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased body weight inducedIAGPcontrolled sodium chloride content diet7771608compared to SHRSP-Chr 1F344/RkbRGD 
decreased heart left ventricle weight  IAGP 7771608 RGD 
decreased heart left ventricle weight  IAGP 7771608; 7771608compared to SHRSPRGD 
decreased mean systemic arterial blood pressure  IAGP 7771608compared to SHRSPRGD 
heart left ventricle hypertrophy  IAGP 7771608 RGD 
increased body weight inducedIAGPcontrolled sodium chloride content diet7771608compared to F344/DuCrlRGD 
increased body weight  IAGP 7771608compared to F344/DuCrlRGD 
increased heart left ventricle weight  IAGP 7771608compared to F344/DuCrlRGD 
increased heart left ventricle weight inducedIAGPcontrolled sodium chloride content diet7771608compared to F344/DuCrlRGD 
increased heart left ventricle weight inducedIAGPcontrolled sodium chloride content diet7771608compared to F344/DuCrl and SHRSP-Chr 1F344/RkbRGD 
increased heart left ventricle weight susceptibilityIAGP 7771608compared to F344RGD 
increased mean systemic arterial blood pressure  IAGP 7771608compared to F344RGD 
increased mean systemic arterial blood pressure inducedIAGPcontrolled sodium chloride content diet7771608compared to F344/DuCrlRGD 
increased mean systemic arterial blood pressure inducedIAGPcontrolled sodium chloride content diet7771608compared to F344/DuCrl and SHRSP-Chr 1F344/RkbRGD 
increased mean systemic arterial blood pressure  IAGP 7771608compared to F344/DuCrlRGD 
Objects Annotated

QTLs
Cm80  (Cardiac mass QTL 80)

Strains
F344/DuCrl  (NA)
F344/NCrl  (NA)
SHRSP-Chr 1F344/Rkb  (NA)
SHRSP/Bbb  (NA)


Additional Information