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Strain: SHR-Tg(EEF1A1-Cd36)10Ipcv

Symbol: SHR-Tg(EEF1A1-Cd36)10Ipcv
Strain: SHR-Tg(EEF1A1-Cd36)10
Substrain: Ipcv
RGD ID: 2302148
Citation ID: RRID:RGD_2302148
Ontology ID: RS:0001686
Alleles: Cd36
Also Known As: SHR/Ola-TgN(Ef1aCd36)10Ipcv;SHR-TG10; SHR-Tg(Ef1a-Cd36)10Ipcv
Type: transgenic
Available Source: Not Available
Origination: Czech Academy of Sciences, Prague, Czech Republic
Description: Generated by microinjecting SHR/OlaIpcv zygotes with wild type Cd36 DNA from WKY cloned into Invitrogen pEF1/V5-HisA vector (with human EEF1A1 promoter)
Last Known Status: Unknown





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Pravenec M, etal., Nat Genet 2001 Feb;27(2):156-8.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Shows slight decrease in blood pressure which maybe due to the overexpression of transgene 1600636
strain_other Harbors 6-8 copies of the transgene 68930
strain_phys_biochem Cd36 expression detected in brain, muscle, liver, heart, fat and kidney 68930

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-01 SHR-Tg(EEF1A1-Cd36)10Ipcv    SHR-Tg(Ef1a-Cd36)10Ipcv    Symbol and/or name change 68913 APPROVED