RGD Reference Report - Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. - Rat Genome Database

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Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.

Authors: Pravenec, M  Landa, V  Zidek, V  Musilova, A  Kren, V  Kazdova, L  Aitman, TJ  Glazier, AM  Ibrahimi, A  Abumrad, NA  Qi, N  Wang, JM  St Lezin, EM  Kurtz, TW 
Citation: Pravenec M, etal., Nat Genet 2001 Feb;27(2):156-8.
RGD ID: 68930
Pubmed: PMID:11175782   (View Abstract at PubMed)
DOI: DOI:10.1038/84777   (Journal Full-text)

Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD36HumanInsulin Resistance  ISOCd36 (Rattus norvegicus) RGD 
Cd36RatInsulin Resistance  IMP  RGD 
Cd36MouseInsulin Resistance  ISOCd36 (Rattus norvegicus) RGD 
SHR/OlaIpcvRatInsulin Resistance inducedIAGPinsulin and controlled fructose content dietcompared to SHR-Tg(Ef1a-Cd36)19Ipcv and SHR-Tg(Ef1a-Cd36)10IpcvRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cd36Ratfatty acid metabolic process  IMP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

Genes (Rattus norvegicus)
Cd36  (CD36 molecule)

Genes (Mus musculus)
Cd36  (CD36 molecule)

Genes (Homo sapiens)
CD36  (CD36 molecule (CD36 blood group))


Additional Information