RGD Reference Report - Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. - Rat Genome Database

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Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.

Authors: Pravenec, M  Landa, V  Zidek, V  Musilova, A  Kren, V  Kazdova, L  Aitman, TJ  Glazier, AM  Ibrahimi, A  Abumrad, NA  Qi, N  Wang, JM  St Lezin, EM  Kurtz, TW 
Citation: Pravenec M, etal., Nat Genet 2001 Feb;27(2):156-8.
RGD ID: 68930
Pubmed: (View Article at PubMed) PMID:11175782
DOI: Full-text: DOI:10.1038/84777

Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.

Annotation

Disease Annotations    
Insulin Resistance  (IAGP,IMP,ISO)

Gene Ontology Annotations    

Biological Process

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

Genes (Rattus norvegicus)
Cd36  (CD36 molecule)

Genes (Mus musculus)
Cd36  (CD36 molecule)

Genes (Homo sapiens)
CD36  (CD36 molecule)


Additional Information