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Strain Registration

Strain: SHRSP-Tg(Tagln-ACE2)6918Bdr

Symbol: SHRSP-Tg(Tagln-ACE2)6918Bdr
Strain: SHRSP-Tg(Tagln-ACE2)6918
Substrain: Bdr
RGD ID: 2302132
Citation ID: RRID:RGD_2302132
Ontology ID: RS:0001684
Alleles: ACE2;   Tagln
Also Known As: SHRSP-ACE2
Type: transgenic
Available Source: Not Available
Origination: Max-Delbruck-Center for Molecular Medicine, Berlin-Buch, Germany
Description: Trangenic line generated by microinjecting 2.8 kb fragment of smooth muscle 22 alpha promoter and cDNA for human ACE2 gene into SHRSP embryos
Last Known Status: Unknown





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function. Rentzsch B, etal., Hypertension. 2008 Nov;52(5):967-73. Epub 2008 Sep 22.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem ACE2 was overexpressed in renal and mesenteric arteries and smaller vessels responsible for blood pressure regulation 2302131