RGD Reference Report - Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. - Rat Genome Database

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Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9.

Authors: Rapp, JP  Garrett, MR  Dene, H  Meng, H  Hoebee, B  Lathrop, GM 
Citation: Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
RGD ID: 61053
Pubmed: PMID:9722941   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.1998.5394   (Journal Full-text)

A blood pressure quantitative trait locus was found (LOD = 5.0) on rat chromosome 9 using a large F2 population (N = 233) derived from Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. The F2 rats were fed 8% NaCl diet for 8 weeks. A congenic strain introgressing the R low-blood-pressure QTL allele on chromosome 9 into the S strain was constructed. The congenic strain, designated S.R(chr 9), had a lower blood pressure (19 mm Hg, P < 0.0001) and lower heart weight (112 mg, P < 0.0001) than S rats (2% NaCl diet for 24 days), proving the existence of a blood pressure QTL in the congenic region of about 21 cM.



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Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp34Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SS.SR-Inha/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.SR-Inha/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
Bp34Ratincreased systemic arterial blood pressure  QTM  RGD 

Related Phenotype Data for this Reference

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Objects Annotated

QTLs
Bp34  (Blood pressure QTL 34)

Strains
SR/Jr  (Salt Resistant)
SS.SR-Inha/Jr  (NA)
SS/Jr  (Salt Sensitive)

Objects referenced in this article
Marker D9Uia6 D9Uia6 Rattus norvegicus
Marker D9Uia9 D9Uia9 Rattus norvegicus
Gene Inha inhibin subunit alpha Rattus norvegicus

Additional Information