Oga (O-GlcNAcase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Oga (O-GlcNAcase) Rattus norvegicus
Analyze
Symbol: Oga
Name: O-GlcNAcase
RGD ID: 621077
Description: Enables beta-N-acetylglucosaminidase activity and histone acetyltransferase activity. Involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of primary metabolic process. Predicted to be located in cytosol and nucleus. Orthologous to human OGA (O-GlcNAcase); PARTICIPATES IN hexosamine biosynthetic pathway; INTERACTS WITH (+)-taxifolin; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-hexosaminidase; beta-N-acetylhexosaminidase; bifunctional protein NCOAT; LOC108349825; meningioma expressed antigen 5 (hyaluronidase); meningioma-expressed antigen 5; Mgea5; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; Ncoat; nuclear cytoplasmic O-GlcNAcase and acetyltransferase; protein O-GlcNAcase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Rf1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,547,311 - 254,589,596 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1254,547,311 - 254,582,855 (-)EnsemblGRCr8
mRatBN7.21244,598,285 - 244,633,835 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,598,292 - 244,634,359 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1252,741,415 - 252,774,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,439,664 - 259,472,395 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,091,600 - 252,124,281 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,506,752 - 265,542,452 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,507,451 - 265,542,276 (-)Ensemblrn6Rnor6.0
Rnor_5.01272,936,992 - 272,972,453 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41250,966,386 - 251,000,363 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,409,329 - 240,439,889 (-)NCBICelera
RGSC_v3.11251,226,954 - 251,260,932 (-)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
colistin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
D-glucose  (ISO)
dapagliflozin  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ferric ammonium citrate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
gentamycin  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
mangiferin  (EXP)
metformin  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
polymyxin B2  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tetrachlorobisphenol A  (EXP)
tetraphene  (ISO)
thiamet G  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats. Akimoto Y, etal., Glycobiology. 2007 Feb;17(2):127-40. Epub 2006 Nov 9.
2. Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc. Champattanachai V, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C178-87. Epub 2006 Aug 9.
3. Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. Copeland RJ, etal., Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E17-28. Epub 2008 Apr 29.
4. Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats. Fulop N, etal., Biogerontology. 2008 Jun;9(3):139-51. Epub 2008 Jan 10.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. Hu Y, et al., J Biol Chem. 2009 Jan 2;284(1):547-55. doi: 10.1074/jbc.M808518200. Epub 2008 Nov 12.
7. Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation. Lima VV, etal., Hypertension. 2009 Feb;53(2):166-74. Epub 2009 Jan 12.
8. Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis. Liu J, etal., Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1391-9. Epub 2007 Jun 15.
9. Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion. Liu K, etal., Mol Cell Endocrinol 2002 Aug 30;194(1-2):135-46.
10. Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cells. Majumdar G, etal., J Biol Chem. 2006 Feb 10;281(6):3642-50. Epub 2005 Dec 6.
11. Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine. Nagy T, etal., Am J Physiol Cell Physiol. 2006 Jan;290(1):C57-65. Epub 2005 Aug 17.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes. Park SY, etal., Exp Mol Med. 2005 Jun 30;37(3):220-9.
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities. Toleman C, etal., J Biol Chem. 2004 Dec 17;279(51):53665-73. Epub 2004 Oct 12.
17. Assignment of N-acetyl-D-glucosaminidase (Mgea5) to rat chromosome 1q5 by tyramide fluorescence in situ hybridization (T-FISH): synteny between rat, mouse and human with Insulin Degradation Enzyme (IDE). Van Tine BA, etal., Cytogenet Genome Res 2003;103(1-2):202B.
Additional References at PubMed
PMID:8034696   PMID:11148210   PMID:16356930   PMID:16517082   PMID:17045574   PMID:19023128   PMID:19946888   PMID:22928023   PMID:25183011   PMID:28131823  


Genomics

Comparative Map Data
Oga
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,547,311 - 254,589,596 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1254,547,311 - 254,582,855 (-)EnsemblGRCr8
mRatBN7.21244,598,285 - 244,633,835 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,598,292 - 244,634,359 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1252,741,415 - 252,774,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,439,664 - 259,472,395 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,091,600 - 252,124,281 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,506,752 - 265,542,452 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,507,451 - 265,542,276 (-)Ensemblrn6Rnor6.0
Rnor_5.01272,936,992 - 272,972,453 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41250,966,386 - 251,000,363 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,409,329 - 240,439,889 (-)NCBICelera
RGSC_v3.11251,226,954 - 251,260,932 (-)NCBI
Cytogenetic Map1q54NCBI
OGA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810101,784,450 - 101,818,444 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10101,784,443 - 101,818,620 (-)Ensemblhg38GRCh38
GRCh3710103,544,207 - 103,578,201 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,534,199 - 103,568,165 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410103,534,198 - 103,568,165NCBI
Celera1097,282,941 - 97,316,962 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,174,738 - 97,208,961 (-)NCBIHuRef
CHM1_110103,827,789 - 103,861,799 (-)NCBICHM1_1
T2T-CHM13v2.010102,667,945 - 102,701,933 (-)NCBIT2T-CHM13v2.0
Oga
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391945,738,698 - 45,772,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1945,738,698 - 45,772,276 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381945,750,255 - 45,783,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1945,750,259 - 45,783,837 (-)Ensemblmm10GRCm38
MGSCv371945,824,749 - 45,857,781 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361945,803,570 - 45,836,602 (-)NCBIMGSCv36mm8
Celera1946,512,464 - 46,545,277 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
Oga
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,478,060 - 8,507,420 (+)Ensembl
ChiLan1.0NW_0049554858,477,615 - 8,509,386 (+)NCBIChiLan1.0ChiLan1.0
OGA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28113,671,182 - 113,705,150 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110113,676,501 - 113,710,045 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,387,144 - 98,421,105 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110101,858,879 - 101,892,479 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,858,879 - 101,892,479 (-)EnsemblpanPan2panpan1.1
OGA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,376,824 - 14,405,409 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,373,452 - 14,404,541 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2814,545,260 - 14,573,838 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02814,844,719 - 14,873,320 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2814,844,723 - 14,872,796 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,391,175 - 14,419,775 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,430,756 - 14,459,345 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,563,076 - 14,591,673 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Oga
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,385,152 - 32,393,135 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,966,405 - 3,994,410 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,983,983 - 3,996,360 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OGA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,822,499 - 112,851,203 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114112,822,494 - 112,851,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214122,674,554 - 122,703,546 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OGA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1994,812,126 - 94,847,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604855,888,484 - 55,923,706 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oga
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,264,616 - 1,297,378 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248311,264,612 - 1,297,406 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Oga
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1245,223,444 - 45,260,179 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Oga
232 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:87
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000054704, ENSRNOT00000065172, ENSRNOT00000067492
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH132562  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11618.0UniSTS
Cytogenetic Map1q54UniSTS
RH132954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,630,830 - 244,631,033 (-)MAPPERmRatBN7.2
mRatBN7.21244,630,830 - 244,631,033 (+)MAPPERmRatBN7.2
Rnor_6.01265,539,297 - 265,539,499NCBIRnor6.0
Rnor_6.01262,926,456 - 262,926,658NCBIRnor6.0
Rnor_5.01270,371,632 - 270,371,834UniSTSRnor5.0
Rnor_5.01272,969,536 - 272,969,738UniSTSRnor5.0
RGSC_v3.41250,998,360 - 250,998,562UniSTSRGSC3.4
Celera1240,437,886 - 240,438,088UniSTS
RH 3.4 Map11621.41UniSTS
Cytogenetic Map1q54UniSTS
RH138718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,633,649 - 244,633,771 (-)MAPPERmRatBN7.2
mRatBN7.21244,633,649 - 244,633,771 (+)MAPPERmRatBN7.2
Rnor_6.01265,542,116 - 265,542,237NCBIRnor6.0
Rnor_6.01262,923,718 - 262,923,839NCBIRnor6.0
Rnor_5.01270,368,894 - 270,369,015UniSTSRnor5.0
Rnor_5.01272,972,355 - 272,972,476UniSTSRnor5.0
RGSC_v3.41251,001,179 - 251,001,300UniSTSRGSC3.4
Celera1240,440,705 - 240,440,826UniSTS
RH 3.4 Map11621.9UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065172   ⟹   ENSRNOP00000059568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,547,311 - 254,582,471 (-)Ensembl
mRatBN7.2 Ensembl1244,598,292 - 244,633,597 (-)Ensembl
Rnor_6.0 Ensembl1265,507,451 - 265,542,276 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099772   ⟹   ENSRNOP00000094869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,547,311 - 254,582,269 (-)Ensembl
mRatBN7.2 Ensembl1244,598,292 - 244,633,242 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109554   ⟹   ENSRNOP00000088821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,547,311 - 254,582,855 (-)Ensembl
mRatBN7.2 Ensembl1244,598,292 - 244,634,359 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156205   ⟹   ENSRNOP00000112378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,547,311 - 254,582,269 (-)Ensembl
RefSeq Acc Id: NM_131904   ⟹   NP_571979
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,547,311 - 254,582,269 (-)NCBI
mRatBN7.21244,598,285 - 244,633,244 (-)NCBI
Rnor_6.01265,508,619 - 265,541,300 (-)NCBI
Rnor_5.01272,936,992 - 272,972,453 (-)NCBI
RGSC_v3.41250,966,386 - 251,000,363 (-)RGD
Celera1240,409,329 - 240,439,889 (-)RGD
Sequence:
RefSeq Acc Id: XM_017588708   ⟹   XP_017444197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,547,311 - 254,589,596 (-)NCBI
mRatBN7.21244,598,285 - 244,633,835 (-)NCBI
Rnor_6.01265,506,752 - 265,542,452 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063271669   ⟹   XP_063127739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,549,401 - 254,582,486 (-)NCBI
RefSeq Acc Id: XM_063271696   ⟹   XP_063127766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,549,402 - 254,589,596 (-)NCBI
RefSeq Acc Id: XM_063271725   ⟹   XP_063127795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,547,311 - 254,582,486 (-)NCBI
RefSeq Acc Id: XM_063271765   ⟹   XP_063127835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,549,402 - 254,582,641 (-)NCBI
RefSeq Acc Id: XM_063271785   ⟹   XP_063127855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,557,329 - 254,582,486 (-)NCBI
RefSeq Acc Id: XM_063271817   ⟹   XP_063127887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,557,329 - 254,589,596 (-)NCBI
RefSeq Acc Id: XR_005488864
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,555,949 - 254,582,486 (-)NCBI
mRatBN7.21244,606,923 - 244,632,896 (-)NCBI
RefSeq Acc Id: XR_010056626
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,555,949 - 254,589,596 (-)NCBI
RefSeq Acc Id: NP_571979   ⟸   NM_131904
- UniProtKB: Q8VIJ5 (UniProtKB/Swiss-Prot),   A0A8I6ALY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444197   ⟸   XM_017588708
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AAH5 (UniProtKB/TrEMBL),   A0A8I6ALY4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059568   ⟸   ENSRNOT00000065172
Ensembl Acc Id: ENSRNOP00000088821   ⟸   ENSRNOT00000109554
Ensembl Acc Id: ENSRNOP00000094869   ⟸   ENSRNOT00000099772
RefSeq Acc Id: XP_063127795   ⟸   XM_063271725
- Peptide Label: isoform X3
- UniProtKB: A0A0H2UI10 (UniProtKB/TrEMBL),   A0A8I6ALY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127739   ⟸   XM_063271669
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063127766   ⟸   XM_063271696
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063127835   ⟸   XM_063271765
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063127887   ⟸   XM_063271817
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063127855   ⟸   XM_063271785
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000112378   ⟸   ENSRNOT00000156205
Protein Domains
GH84

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIJ5-F1-model_v2 AlphaFold Q8VIJ5 1-916 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690952
Promoter ID:EPDNEW_R1477
Type:single initiation site
Name:Mgea5_1
Description:meningioma expressed antigen 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01265,542,206 - 265,542,266EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621077 AgrOrtholog
BioCyc Gene G2FUF-55535 BioCyc
BioCyc Pathway PWY-7437 [protein O-[N-acetyl]-glucosylation] BioCyc
BioCyc Pathway Image PWY-7437 BioCyc
Ensembl Genes ENSRNOG00000017822 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000065172 ENTREZGENE
  ENSRNOT00000109554 ENTREZGENE
  ENSRNOT00000156205 ENTREZGENE
Gene3D-CATH 3.40.630.30 UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot
  STAT, domain 1 UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  Beta-N-acetylglucosaminidase UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
  Glycosyl_Hydrolase_84 UniProtKB/Swiss-Prot
KEGG Report rno:154968 UniProtKB/Swiss-Prot
NCBI Gene 154968 ENTREZGENE
PANTHER O-GLCNACASE UniProtKB/Swiss-Prot
  PROTEIN O-GLCNACASE UniProtKB/Swiss-Prot
Pfam NAGidase UniProtKB/Swiss-Prot
PhenoGen Oga PhenoGen
PROSITE GH84 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017822 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
  SSF55729 UniProtKB/Swiss-Prot
UniProt A0A0H2UI10 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALY4 ENTREZGENE, UniProtKB/TrEMBL
  OGA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Oga  O-GlcNAcase  LOC108349825  protein O-GlcNAcase-like  Data merged from RGD:11512775 737654 PROVISIONAL
2018-04-24 Oga  O-GlcNAcase  Mgea5  meningioma expressed antigen 5 (hyaluronidase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-02 LOC108349825  protein O-GlcNAcase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Mgea5  meningioma expressed antigen 5 (hyaluronidase)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mgea5  meningioma expressed antigen 5 (hyaluronidase)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs increased levels induced by streptozotocin are associated with pancreatic beta cell apoptosis and defective insulin secretion 1299304