| 11041108 | CV/Iet | | The Laboratory of Reproductive Toxicology at the Institute of Environmental Toxicology has been maintaining a Wistar derived PD strain of rats. In 1986, 1 female and 2 males exhibiting very short and sparse vibrissae were fo und in a litter of 7 parented by a pd/pd female and phenotypically normal pd/+ male. In 2008, a male Wistar rat and F56 female were crossed, and obtained heterozygous rats were sib-mated. After that, sib mating between homozygous rats was started. | National BioResource Project for the Rat in Japan | mutant | 1 | origin |
| 11041143 | PL/Iet | | A new mutant gene that causes preaxial polydactyl in the hindlimbs was found in the Jcl:Wistar -derived strain of rats with fused pulmonary lobes (FRL) at the Laboratory of Reproductive Toxicology at the Institute of Environmental Tox Toxicology . Genetic analysis has revealed that the new mutation is not closely linked with the fpl gene. This strain was established by sib mating (over 20 generations). | National BioResource Project for the Rat in Japan | inbred | 1 | origin |
| 631604 | SHR/Snk | | The original WKY animals were bred at the Animal Science and Toxicology Laboratories in Japan. | | inbred | 11 | origin |
| 631603 | WKY/Snk | | The original WKY animals were bred at the Animal Science and Toxicology Laboratories in Japan. | | inbred | 3 | origin |
| 596938164 | CrlNctr:CD(SD) | | A colony of outbred Crl:CD(SD) (RGD:734476) maintained at National Center for Toxicological Research, FDA. | Charles River Laboratories | outbred | 1 | origin |
| 13506919 | F344/Nctr | Fischer | Curtiss and Dunning 1920 at Columbia University Institute for Cancer Research, To National Center for Toxicological Research, FDA. | | inbred | 1 | origin |
| 10395235 | F344/NSim | FISCHER 344 | Gnotobiotic pedigreed breeders received from the NIH repository colony in 2005. Most widely used inbred rat strain, particularly for toxicology and teratology. | Simonsen Laboratories | inbred | 1 | origin |
| 13464329 | FPL/Iet | Fused pulmonary lobes, FPL | This spontaneous mutant strain wa found in a colony of Jcl:Wistar strain at the Institute of Environmental Toxicology in 1978: 3 rats out of 13 rats showed fused right pulmonary lobes with reduction deformity of middle pulmonary lobes. These rats also had the s yndactylism or paten tof the eyelid. It was difficult to maintain this strain in homozygous condition, mating system has been changed to sib mating between heterozygous rats. | National BioResource Project for the Rat in Japan | mutant | 5 | origin |
| 1300432 | HAA/FDSC | Hatano High Avoidance | In 1985 two lines of Sprague-Dawley were selectively bred for their active shuttle-box avoidance task which is a device used for evaluating the effects of chemicals in pharmacological and toxicological studies and testing learning behavior of animals. These anim als have a higher rate of avoidance response and showed little interindividual variation. | National BioResource Project for the Rat in Japan | inbred | 1 | origin |
| 126790511 | Jcl:WIST | | CLEA Japan, Inc., Taconic Farms Inc. (USA), and Taconic Europe (Denmark) created the Global Alliance for Laboratory Animal Standardization (GALASTM) agreement in collaboration with the Central Institute for Experimental Animals to promote the international standardization of outbred stocks usable fo r safety testing in the field of toxicity and pharmacology. Based on these activities,Wistar Hannover GALAS rats are derived from the Han:WIST strain from the Zentral Institut fur Versuchstierzucht (ZfV) (Hannover, Germany). In 1989, 156 pairs were introduced from ZfV to the Institute for Biomedical Research (IBM) in Switzerland (IBM underwent a structural change [name change] to BRL Ltd. and RCC Ltd.). At and after the end of 1998, RCC Ltd. gave more than 50 pairs of pedigreed BrlHan:WIST rats to each GALAS member to use as seed rats for the Wistar Hannover GALAS strain. | CLEA Japan, Inc | outbred | 1 | origin |
| 1300433 | LAA/FDSC | Hatano Low Avoidance | In 1985 two lines of Sprague-Dawley were selectively bred for their active shuttle-box avoidance task which is a device used for evaluating the effects of chemicals in pharmacological and toxicological studies and testing learning behavior of animals. These anim als have a lower rate of avoidance response and showed little interindividual variation. | National BioResource Project for the Rat in Japan | inbred | 6 | origin |
| 628486 | NER/Kyo | Noda epileptic rat, GMS | Originated in a group of Crj:Wistar rats which were developed and maintained at the Research Institute for Animal Science in Biotechnology and Toxicology, Kanagawa, Japan. | National BioResource Project for the Rat in Japan | inbred | 5 | origin |
| 597830029 | Pha:WI | Wistar rats | The outbred Wistar rats are maintained at Breeding station Dobrá Voda, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Science, Slovak Republic. | Breeding station Dobrá Voda, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Science, Slovak Republic | outbred | 1 | origin |
| 8552244 | SD-Tg(Dsp-mCherry-DTR)Jfln | | This rat carries a transgene consisting of the Dsp promoter followed by a STOP cassette flanked by FRT sites. The stop cassette consists of an mcherry gene encoding for a red fluorescent protein and a kanamycin resistant gene and three SV40polyA adenylation signals. The STOP cassette is followed by a gene encoding for the human diphtheria toxin receptor. Red fluorescence can be detected from the skin of the animals but not the brain. | National BioResource Project for the Rat in Japan | transgenic | 1 | origin |
| 8552247 | SD-Tg(Neurod6-mCherry-DTR)Jfln | | This rat carries a transgene consisting of the NeuroD6 promoter followed by a STOP cassette flanked by FRT sites. The stop cassette consists of an mcherry gene encoding for a red fluorescent protein and a kanamycin resistant gene and three SV40polyA adenylation signals. The STOP cassette is followed by a gene encoding for the human diphtheria toxin receptor. This model is yet to be validated. | National BioResource Project for the Rat in Japan | transgenic | 1 | origin |
| 12879432 | W-Ift140em1Kyo | | This strain was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 1 (em1) has 2-bp insertion (c.23_24insGG) in the exon 1 of Ift140 (intraflagellar transpor t 140) gene. | National BioResource Project for the Rat in Japan | mutant | 1 | origin |
| 12879434 | W-Ift140em2Kyo | | This strain was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 2 (em2) has 2-bp deletion (c.23_24del) in the exon 1 of Ift140 (intraflagellar transport 1 40) gene. | National BioResource Project for the Rat in Japan | mutant | 1 | origin |
| 61007 | WF | Wistar Furth | J Furth 1945 from a commercial Wistar stock in an attempt to develop a high leukaemia rat strain. Strain carries a distinctive heteropycnotic Y chromosome which may be used as a cellular marker (Zieverink and Moloney 1965). A substrain carrying the fuzzy mutation, which arose spontaneously in WF has been used in research on dermal toxicity, and is described in more detail by Marit et al, (1995). | | inbred | 8 | origin |
| 13464327 | WKY.Cg-clest/Iet | | When the depositor (The Institute of Environmental Toxicology ) conducted mating experiment using male Crl:CD(SD) rats, the offsprings of backcrossed-generation showed multiple malformations such as ectrodactylism, cleft palate or lip in 2013. These phenotype m ight be inherited in an autosomal recessive pattern. Therefore the congenic strain was established using WKY strain as the recipient strain. | National BioResource Project for the Rat in Japan | congenic | 1 | origin |
