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Strain Registration

Strain: PL/Iet

Symbol: PL/Iet
Strain: PL
Substrain: Iet
RGD ID: 11041143
Citation ID: RRID:RGD_11041143
Ontology ID: RS:0004170
Also Known As: Polydactyly Lethal; NBRP Rat No: 0818
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: A new mutant gene that causes preaxial polydactyl in the hindlimbs was found in the Jcl:Wistar -derived strain of rats with fused pulmonary lobes (FRL) at the Laboratory of Reproductive Toxicology at the Institute of Environmental Toxicology . Genetic analysis has revealed that the new mutation is not closely linked with the fpl gene. This strain was established by sib mating (over 20 generations).
Coat Color: albino
Inbred Generations: F20
Last Known Status: Cryopreserved Sperm
Research Usage Development






References

References - curated
# Reference Title Reference Citation
1. Polydactyly lethal: a new mutant spontaneously occurring in the FPL strain of rats. Aoyama H, etal., J Hered. 1991 Sep-Oct;82(5):397-401.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Genetic analysis has revealed that the new mutation is inherited as an autosomal recessive trait and is not closely linked with the fpl gene. The causative gene is not identified. Homozygous mutants have preaxial polydactyly in the hindlimbs and die within the first 2 days after birth. In some cases, phalangeal duplication or bifurcation in digit I with thickening of metacarpal I was also found in the forelimbs, although extra forelimb digits were not detected externally. The pl/pl newborns showed hunchback-like abnormal posture externally and had several associated vertebral abnormalities in varying degrees. 1302502
strain_reproduction sib mating (heterozygous x heterozygous) 1302502