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Strain Registration

Strain: NER/Kyo

Symbol: NER/Kyo
Strain: NER
Substrain: Kyo
Full Name: Noda epileptic rat, GMS
RGD ID: 628486
Citation ID: RRID:RGD_628486
Ontology ID: RS:0000606
Also Known As: NBRP Rat No: 0010; NER; MDC-02-17
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Originated in a group of Crj:Wistar rats which were developed and maintained at the Research Institute for Animal Science in Biotechnology and Toxicology, Kanagawa, Japan.
Coat Color: Albino
Inbred Generations: F29
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Neurobiology





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Chromosomal mapping of genes for epilepsy in NER: a rat strain with tonic-clonic seizures. Maihara T, etal., Epilepsia 2000 Aug;41(8):941-9.
2. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
3. NER rat strain: a new type of genetic model in epilepsy research. Noda A, etal., Epilepsia 1998 Jan;39(1):99-107.
4. Regional expression of Fos-like immunoreactivity following seizures in Noda epileptic rat (NER). Ohno Y, etal., Epilepsy Res. 2009 Aug 25.
5. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
8. Regional excitatory and inhibitory amino acid concentrations in Noda epileptic rat (NER) brain. Sejima H, etal., Brain Dev 1999 Sep;21(6):382-5.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy No abnormalilties have been observed in the histopathological studies. 628480
strain_characteristics Even at 2 months of age these exhibit abnormal behavior like sudden arrest of motion, neck spasms, jumping backwards, lifting of the forelimbs and crying for a few seconds. At a later age the seizures occurred in the following order: neck and fore limb clonus, wild jumping/running, opisthotonic posture, followed by tonic convulsion, clonic convulsion and then postictal flaccid state of the whole body. 628480
strain_characteristics GTC seizures originate in the forebrain; evoked by activation of cortical- and/or limbic-seizure circuits 2313241
strain_life_disease After F9 generation 94%-98% animals exhibited spontaneous tonic-clonic convulsions. These began with neck and forelimb clonus, wild jumping/running and opisthotonic postures. Most seizures were observed between 2-4 months of age. Pregnant and suckling female adult rats had a lower rate of seizures. 628480
strain_phys_biochem During a general seizure the cerebullum is electrically and metabolically active.The cerebellum of these animals maybe in an excited state to dampen seizure, it has a high concentration of glycine and a lower concentration of taurine than the F344 rats. 628480
strain_phys_biochem piriform cortex, perirhinal-entorhinal cortex, insular cortex and other cortices have increased Fos expression 2313241
strain_reproduction This strain has a good breeding performance. The copulation index, fertility index and the gestation index were above 80%. 628480