Mirlet7g (microRNA let-7g) - Rat Genome Database

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Gene: Mirlet7g (microRNA let-7g) Rattus norvegicus
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Symbol: Mirlet7g
Name: microRNA let-7g
RGD ID: 9685094
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including miRNA-mediated post-transcriptional gene silencing; negative regulation of leukocyte adhesion to vascular endothelial cell; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including cellular response to forskolin; cellular response to lipopolysaccharide; and miRNA-mediated gene silencing by inhibition of translation. Predicted to be part of RISC complex. Orthologous to human MIRLET7G (microRNA let-7g); INTERACTS WITH cadmium atom; cadmium dichloride; cisplatin.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-let-7g
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,701,020 - 115,701,107 (+)NCBIGRCr8
mRatBN7.28106,822,293 - 106,822,380 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,822,280 - 106,822,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8112,446,859 - 112,446,946 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,646,020 - 110,646,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,488,826 - 108,488,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08114,874,457 - 114,874,544 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,874,454 - 114,874,550 (+)EnsemblRnor6.0rn6Rnor6.0
Celera8106,144,521 - 106,144,608 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18723672   PMID:18762567   PMID:21993888   PMID:22301161   PMID:23185045   PMID:23329697   PMID:23646144   PMID:25751060   PMID:27889560   PMID:28108289   PMID:37433785  


Genomics

Comparative Map Data
Mirlet7g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,701,020 - 115,701,107 (+)NCBIGRCr8
mRatBN7.28106,822,293 - 106,822,380 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,822,280 - 106,822,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8112,446,859 - 112,446,946 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,646,020 - 110,646,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,488,826 - 108,488,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08114,874,457 - 114,874,544 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,874,454 - 114,874,550 (+)EnsemblRnor6.0rn6Rnor6.0
Celera8106,144,521 - 106,144,608 (+)NCBICelera
Cytogenetic Map8q32NCBI
MIRLET7G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,268,278 - 52,268,361 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,268,278 - 52,268,361 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,302,294 - 52,302,377 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,277,333 - 52,277,416 (-)NCBINCBI36Build 36hg18NCBI36
Celera352,281,606 - 52,281,689 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef352,364,465 - 52,364,548 (-)NCBIHuRef
CHM1_1352,254,824 - 52,254,907 (-)NCBICHM1_1
T2T-CHM13v2.0352,301,168 - 52,301,251 (-)NCBIT2T-CHM13v2.0
Mirlet7g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,056,039 - 106,056,126 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,056,039 - 106,056,126 (+)EnsemblGRCm39 Ensembl
GRCm389106,178,840 - 106,178,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,178,840 - 106,178,927 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,081,171 - 106,081,258 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9105,803,963 - 105,804,050 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.46NCBI
MIRLET7G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,501,074 - 37,501,152 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,501,054 - 37,501,160 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,482,632 - 37,482,710 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,851,450 - 37,851,528 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,851,430 - 37,851,536 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,215,139 - 37,215,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,623,891 - 37,623,969 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,908,500 - 37,908,578 (+)NCBIUU_Cfam_GSD_1.0
MIRLET7G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,406,130 - 34,406,225 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,406,140 - 34,406,219 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,599,004 - 37,599,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 13 52 28 29 12 16 12 64 37 44 8 18 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_128664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000072553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8106,822,280 - 106,822,388 (+)Ensembl
Rnor_6.0 Ensembl8114,874,454 - 114,874,550 (+)Ensembl
RefSeq Acc Id: NR_128664
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88115,701,020 - 115,701,107 (+)NCBI
mRatBN7.28106,822,293 - 106,822,380 (+)NCBI
Rnor_6.08114,874,457 - 114,874,544 (+)NCBI
Celera8106,144,521 - 106,144,608 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:9685094 AgrOrtholog
BioCyc Gene G2FUF-29252 BioCyc
Ensembl Genes ENSRNOG00000050242 Ensembl
miRBase MI0030347 ENTREZGENE
NCBI Gene Mirlet7g ENTREZGENE
PhenoGen Mirlet7g PhenoGen
RatGTEx ENSRNOG00000050242 RatGTEx
RNAcentral URS00000B0351 RNACentral
  URS000029979D RNACentral
  URS00004AFF8D RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-16 Mirlet7g  microRNA let-7g      Symbol and Name status set to provisional 70820 PROVISIONAL