Zfp597 (zinc finger protein 597) - Rat Genome Database

Name: Zfp597
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Zfp597 (zinc finger protein 597) Rattus norvegicus

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Symbol:

Zfp597

Name:

zinc finger protein 597

RGD ID:

628674

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF597 (zinc finger protein 597); INTERACTS WITH 17alpha-ethynylestradiol; acetamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Hit4; zinc finger protein HIT-4; Znf597

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	12,159,533 - 12,165,207 (+)	NCBI		GRCr8
mRatBN7.2	10	11,653,169 - 11,658,843 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	11,653,127 - 11,660,675 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	16,360,710 - 16,366,365 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	15,849,542 - 15,855,197 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	11,518,366 - 11,524,032 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	11,912,245 - 11,917,919 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	11,912,543 - 11,917,898 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	10,668,608 - 10,674,282 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	11,920,710 - 11,926,384 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	11,910,401 - 11,926,711 (+)	NCBI
Celera	10	10,609,640 - 10,615,304 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

idiopathic generalized epilepsy (ISO)

Rubinstein-Taybi syndrome (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

beta-hexachlorocyclohexane (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

folic acid (ISO)

fonofos (ISO)

gentamycin (EXP)

lidocaine (EXP)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

N-methyl-4-phenylpyridinium (EXP)

ozone (ISO)

paracetamol (EXP)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

terbufos (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

nucleus (IBA)

Molecular Function

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Information Derived from GenBank Report	RGD, Sept. 2003
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:19968752

Genomics

Comparative Map Data

Zfp597
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	12,159,533 - 12,165,207 (+)	NCBI		GRCr8
mRatBN7.2	10	11,653,169 - 11,658,843 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	11,653,127 - 11,660,675 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	16,360,710 - 16,366,365 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	15,849,542 - 15,855,197 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	11,518,366 - 11,524,032 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	11,912,245 - 11,917,919 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	11,912,543 - 11,917,898 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	10,668,608 - 10,674,282 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	11,920,710 - 11,926,384 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	11,910,401 - 11,926,711 (+)	NCBI
Celera	10	10,609,640 - 10,615,304 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

ZNF597
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	3,432,414 - 3,443,504 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	3,432,414 - 3,443,504 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	3,482,414 - 3,493,504 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	3,426,111 - 3,433,491 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	3,426,111 - 3,433,491	NCBI
Celera	16	3,692,878 - 3,700,261 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	3,455,775 - 3,463,160 (-)	NCBI		HuRef
CHM1_1	16	3,486,236 - 3,493,616 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	3,459,676 - 3,470,773 (-)	NCBI		T2T-CHM13v2.0

Zfp597
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	3,679,408 - 3,702,241 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	3,676,185 - 3,702,425 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	3,861,544 - 3,884,377 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	3,858,321 - 3,884,561 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	3,861,544 - 3,872,374 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	3,776,772 - 3,787,602 (-)	NCBI		MGSCv36	mm8
Celera	16	4,492,047 - 4,502,876 (-)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	2.27	NCBI

Znf597
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	13,926,440 - 13,935,055 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	13,926,675 - 13,933,490 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZNF597
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	3,958,835 - 3,970,507 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	7,743,651 - 7,755,334 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	2,355,696 - 2,366,850 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	3,532,027 - 3,543,377 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	3,532,027 - 3,543,377 (-)	Ensembl	panpan1.1		panPan2

ZNF597
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	37,793,406 - 37,798,568 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	37,793,585 - 37,798,541 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	26,312,015 - 26,317,485 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	38,008,560 - 38,014,038 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	38,008,760 - 38,016,823 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	37,791,512 - 37,796,978 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	37,684,839 - 37,690,305 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	38,095,392 - 38,100,862 (+)	NCBI		UU_Cfam_GSD_1.0

Znf597
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	105,852,422 - 105,860,072 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936694	849,681 - 856,887 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936694	849,369 - 854,290 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZNF597
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	38,788,447 - 38,798,609 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	40,154,366 - 40,162,427 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZNF597
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	3,137,252 - 3,144,217 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	3,133,193 - 3,144,023 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	27,677,324 - 27,687,782 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Znf597
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624824	1,235,356 - 1,254,877 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624824	1,235,666 - 1,255,332 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Zfp597
12 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	65
Count of miRNA genes:	57
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000045192
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	29497586	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_153732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF277900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000045192 ⟹ ENSRNOP00000048154

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	11,653,127 - 11,660,675 (+)	Ensembl
Rnor_6.0 Ensembl	10	11,912,543 - 11,917,898 (+)	Ensembl

RefSeq Acc Id:

NM_153732 ⟹ NP_714954

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	12,159,533 - 12,165,207 (+)	NCBI
mRatBN7.2	10	11,653,169 - 11,658,843 (+)	NCBI
Rnor_6.0	10	11,912,245 - 11,917,919 (+)	NCBI
Rnor_5.0	10	10,668,608 - 10,674,282 (+)	NCBI
RGSC_v3.4	10	11,920,710 - 11,926,384 (+)	RGD
Celera	10	10,609,640 - 10,615,304 (+)	RGD

Sequence:

show sequence

GGAGCATGGGAGCGTGGGAGTTTTGTGGTGGCCTCCGCCTCCTTTGTAGCGTCTCGGCTGGGCG
TGGCTTCATGCTGCTTCTGCCGGGTTGGGCGAGGCTGTCAGTGCTCCCGGGCTGGTGAGTGGCC
GCTTCAAGGCTGTTTTGGAGAAAGAAGCCTTCACCTCAGATTCTCAAAGGAGCTTGAAGGTTCC
GAGGAGCCTGAGGGTGGAGTGGAAAGGCCTGGCAGCGGAGTTGGAGACTCTCTGCTCGAAGTGT
TGTCCCAACGTAGGGACTTGAAGGAGCCCTTCGTTTCCCCAGATGGCGTCCACGCTCCCCACAT
CCGATGAGCAGGGACCACTGCTCTTTGAAGATCTGGATGTGTATTTTTCTCAAGAGGAATGTGT
GAGTCTGCACTCTTCCCAGAAGACCCTCAGCAGAGAAGCCCCGTTGGAGTCTTTTGAGGATTTG
AACTTGACAGGGGAAGACCGGACTGAGACCAGTCAGAAGTTAAGCCTAGAGCCTCTAGAACTTG
AAGAGCTGTCCCTAGAAACGTACTCCACTGCTGTACCCCTTGTCCGCTACTTAGAGCAGCCTGA
GGAGGATGTTGAAGTACATGAAAGGAAAATGTCAGGCGGAACTTTGACTTGCAAGACCAAGCTT
GTAAACCTCTTGGTTACTATTGACAACCAAACTCCATTAGAAGAGTTATCTCAGTGTTTAGGAG
TCAAAACACTTTCAGATATTATTGAAGTTCCCTGGGAAGAAGCCAAAAATGTGTTCCAGTGTCC
TGACTGTGACCAAAGCTTCAGTGATAATACATACCTTGTTTTGCATCAGAAAATTCATTCAAGA
GAGAGAAAGTATAAATGTGGTACCTGTGAGAAGACCTTCAGTCACCGAACCAACCTGAAGACAC
ACAGGCGAATCCACACCGGAGAGAAGCCTTACAAGTGTACCGAGTGTGCTGCCAGCTTCCGACA
GCAGTCACACCTGACCCGGCACATGAATAGCCATTTAAAGGAGAAACCATACACATGTAGTGTA
TGTGGGAGAGGTTTTATGTGGCTCCCCGGATTGGCAGAACATCAGAAGAGTCATACTGATACGG
AGTCTTACGAGAGTGCTGACCATGATCAGGAAACAAGTCTGGCTTTGCCTGAAGAAAGAGGCTC
TTCAGACACACCATCCCAGCACGCACAGTGTGTGGGGACCTCGGAGCAGCCCTCAGAGCCTGCT
CTCCCCGACAAAGACAACCATAAGGAGAATGCTAAACACTGCAGCATCGATGATGAAGACTTCT
TTTCCTTCTCCAGATTCAAACCCTTACAGTGTCTTGATTGTGACATGACTTTTCCTTGTTTCTC
GGAGCTTGTCTCTCACCAAACCATCCACGACATGGAGAAAACTCATAAGTGCAAAACATGTGCA
AAGACCTTTGCTTTAGAGTCCGACCTCGCGAGTCACGAGAAGAGCCACAGAAGAGAGGAGCCCT
TTAAATGTACAGTGTGTGGGAAGAGCTTCAGAGTAAACGTGCAGCTCATCGCTCATAAACGAAC
CCATAGGAGAAACAGCAAGTAAATACAGGCTTTTGCTACTGTTAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_714954	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG53886	(Get FASTA)	NCBI Sequence Viewer
	AAH78709	(Get FASTA)	NCBI Sequence Viewer
	EDL96319	(Get FASTA)	NCBI Sequence Viewer
	EDL96320	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048154.4

RefSeq Acc Id:

NP_714954 ⟸ NM_153732

- UniProtKB:

Q6AZ70 (UniProtKB/TrEMBL), F1LLV0 (UniProtKB/TrEMBL), A6K4U7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASTLPTSDEQGPLLFEDLDVYFSQEECVSLHSSQKTLSREAPLESFEDLNLTGEDRTETSQKL
SLEPLELEELSLETYSTAVPLVRYLEQPEEDVEVHERKMSGGTLTCKTKLVNLLVTIDNQTPLE
ELSQCLGVKTLSDIIEVPWEEAKNVFQCPDCDQSFSDNTYLVLHQKIHSRERKYKCGTCEKTFS
HRTNLKTHRRIHTGEKPYKCTECAASFRQQSHLTRHMNSHLKEKPYTCSVCGRGFMWLPGLAEH
QKSHTDTESYESADHDQETSLALPEERGSSDTPSQHAQCVGTSEQPSEPALPDKDNHKENAKHC
SIDDEDFFSFSRFKPLQCLDCDMTFPCFSELVSHQTIHDMEKTHKCKTCAKTFALESDLASHEK
SHRREEPFKCTVCGKSFRVNVQLIAHKRTHRRNSK

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Ensembl Acc Id:

ENSRNOP00000048154 ⟸ ENSRNOT00000045192

Protein Domains

C2H2-type KRAB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AZ70-F1-model_v2	AlphaFold	Q6AZ70	1-419	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628674	AgrOrtholog
BioCyc Gene	G2FUF-25992	BioCyc
Ensembl Genes	ENSRNOG00000007576	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000045192.5	UniProtKB/TrEMBL
Gene3D-CATH	6.10.140.140	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7113822	IMAGE-MGC_LOAD
InterPro	KRAB_dom_sf	UniProtKB/TrEMBL
	Krueppel-associated_box	UniProtKB/TrEMBL
	Krueppel_C2H2_ZnF	UniProtKB/TrEMBL
	Znf_C2H2/integrase_DNA-bd	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
KEGG Report	rno:266774	UniProtKB/TrEMBL
MGC_CLONE	MGC:93126	IMAGE-MGC_LOAD
NCBI Gene	266774	ENTREZGENE
PANTHER	FI01424P-RELATED	UniProtKB/TrEMBL
	KRAB DOMAIN C2H2 ZINC FINGER	UniProtKB/TrEMBL
	ZINC FINGER AND SCAN DOMAIN-CONTAINING	UniProtKB/TrEMBL
	ZINC FINGER IMPRINTED 2	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 597	UniProtKB/TrEMBL
Pfam	KRAB	UniProtKB/TrEMBL
	zf-C2H2	UniProtKB/TrEMBL
	zf-C2H2_6	UniProtKB/TrEMBL
PhenoGen	Zfp597	PhenoGen
PROSITE	KRAB	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007576	RatGTEx
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	Krueppel-associated_box	UniProtKB/TrEMBL
	SSF57667	UniProtKB/TrEMBL
UniProt	A6K4U7	ENTREZGENE, UniProtKB/TrEMBL
	F1LLV0	ENTREZGENE
	Q6AZ70	ENTREZGENE, UniProtKB/TrEMBL
	Q99PJ9_RAT	UniProtKB/TrEMBL
UniProt Secondary	F1LLV0	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-07-19	Zfp597	zinc finger protein 597	Znf597	zinc finger protein 597	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Znf597	zinc finger protein 597	Zfp597	zinc finger protein 597	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Zfp597	zinc finger protein 597			Symbol and Name updated	1299863	APPROVED
2003-02-27	Hit4	zinc finger protein HIT-4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar