Giot1 (gonadotropin inducible ovarian transcription factor 1) - Rat Genome Database

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Gene: Giot1 (gonadotropin inducible ovarian transcription factor 1) Rattus norvegicus
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Symbol: Giot1
Name: gonadotropin inducible ovarian transcription factor 1
RGD ID: 620184
Description: Predicted to enable metal ion binding activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,868,517 - 10,886,965 (-)NCBIGRCr8
mRatBN7.2710,215,602 - 10,236,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,202,982 - 10,237,099 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,090,419 - 13,108,886 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,968,504 - 14,986,971 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,830,404 - 12,848,797 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,104,166 - 13,122,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,104,481 - 13,108,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,265,909 - 13,267,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,736,243 - 11,754,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,736,242 - 11,754,679 (-)NCBI
Celera78,383,278 - 8,401,713 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mizutani T, etal., Mol Endocrinol 2001 Oct;15(10):1693-705.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16904636   PMID:34713942  


Genomics

Comparative Map Data
Giot1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,868,517 - 10,886,965 (-)NCBIGRCr8
mRatBN7.2710,215,602 - 10,236,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,202,982 - 10,237,099 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,090,419 - 13,108,886 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,968,504 - 14,986,971 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,830,404 - 12,848,797 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,104,166 - 13,122,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,104,481 - 13,108,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,265,909 - 13,267,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,736,243 - 11,754,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,736,242 - 11,754,679 (-)NCBI
Celera78,383,278 - 8,401,713 (-)NCBICelera
Cytogenetic Map7q11NCBI
Gm4924
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391082,190,087 - 82,215,477 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1082,190,089 - 82,258,716 (+)EnsemblGRCm39 Ensembl
GRCm381082,354,525 - 82,379,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1082,354,255 - 82,422,882 (+)EnsemblGRCm38mm10GRCm38
MGSCv371081,817,124 - 81,842,385 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361081,784,121 - 81,811,036 (+)NCBIMGSCv36mm8
MGSCv361082,504,350 - 82,529,773 (+)NCBIMGSCv36mm8
Celera1084,299,936 - 84,305,616 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI

Variants

.
Variants in Giot1
295 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000011117
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH139886  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2710,218,066 - 10,218,249 (+)MAPPERmRatBN7.2
Rnor_6.0713,104,314 - 13,104,496NCBIRnor6.0
Rnor_5.0713,266,044 - 13,266,226UniSTSRnor5.0
RGSC_v3.4711,736,378 - 11,736,560UniSTSRGSC3.4
Celera78,383,413 - 8,383,595UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000080491   ⟹   ENSRNOP00000074725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,202,982 - 10,237,099 (-)Ensembl
Rnor_6.0 Ensembl713,104,481 - 13,108,723 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087038   ⟹   ENSRNOP00000072531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl713,104,481 - 13,108,630 (-)Ensembl
RefSeq Acc Id: NM_133563   ⟹   NP_598247
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,868,530 - 10,886,965 (-)NCBI
mRatBN7.2710,217,932 - 10,236,369 (-)NCBI
Rnor_6.0713,104,179 - 13,122,614 (-)NCBI
Rnor_5.0713,265,909 - 13,267,989 (-)NCBI
RGSC_v3.4711,736,243 - 11,754,679 (-)RGD
Celera78,383,278 - 8,401,713 (-)RGD
Sequence:
RefSeq Acc Id: XM_063262949   ⟹   XP_063119019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,868,517 - 10,886,918 (-)NCBI
RefSeq Acc Id: XM_063262950   ⟹   XP_063119020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,868,517 - 10,886,956 (-)NCBI
Protein Sequences
Protein RefSeqs NP_598247 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119019 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119020 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB63446 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074725.2
RefSeq Acc Id: NP_598247   ⟸   NM_133563
- UniProtKB: Q91XV2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074725   ⟸   ENSRNOT00000080491
Ensembl Acc Id: ENSRNOP00000072531   ⟸   ENSRNOT00000087038
RefSeq Acc Id: XP_063119020   ⟸   XM_063262950
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119019   ⟸   XM_063262949
- Peptide Label: isoform X1
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8T1-F1-model_v2 AlphaFold A0A0G2K8T1 1-653 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620184 AgrOrtholog
BioCyc Gene G2FUF-34868 BioCyc
Ensembl Genes ENSRNOG00000051563 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080491.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Krueppel_C2H2_ZnFinger UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:171090 UniProtKB/TrEMBL
NCBI Gene 171090 ENTREZGENE
PANTHER EXPRESSED SEQUENCE AW146154-RELATED UniProtKB/TrEMBL
  IP01015P-RELATED UniProtKB/TrEMBL
  OTTMUSG00000016588 PROTEIN-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/TrEMBL
PhenoGen Giot1 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051563 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2K8T1_RAT UniProtKB/TrEMBL
  Q91XV2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Giot1  gonadotropin inducible ovarian transcription factor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Giot1  gonadotropin inducible ovarian transcription factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains amino terminus contains kruppel-associated box-A domain 632669
gene_expression expression in the pituitary, adrenal, testis, and ovary 632669
gene_function functions as a transcriptional repressor 632669
gene_process plays a significant role at the transcription level during folliculogenesis 632669
gene_product member of the (Cys)(2)-(His)(2)-type zinc finger protein family 632669
gene_regulation mRNA is induced by theca interna cells in the ovary and Leydig cells in the testis 632669