Prp15 (proline-rich protein 15) - Rat Genome Database

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Gene: Prp15 (proline-rich protein 15) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prp15
Name: proline-rich protein 15
RGD ID: 3413
Description: Predicted to be located in extracellular region. Orthologous to human PRH2 (proline rich protein HaeIII subfamily 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; endosulfan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Proline-rich protein salivary; Proline-rich protein, salivary; Prp; Prpb; RATRP13; Rp13
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84167,559,867 - 167,563,414 (-)NCBIGRCr8
mRatBN7.24165,828,456 - 165,832,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4165,828,456 - 165,832,004 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4172,124,808 - 172,128,354 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04167,907,829 - 167,911,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04166,541,863 - 166,545,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04166,222,418 - 166,293,492 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4166,222,451 - 166,224,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04228,749,393 - 228,820,151 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44169,850,594 - 169,853,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14170,095,529 - 170,098,622 (-)NCBI
Celera4154,400,333 - 154,403,595 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular characterization of rat multigene family encoding proline-rich proteins. Lin HH and Ann DK, Genomics 1991 May;10(1):102-13.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1618808  


Genomics

Variants

.
Variants in Prp15
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:77
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000007119, ENSRNOT00000007139, ENSRNOT00000045884
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
D4Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04228,788,206 - 228,788,578NCBIRnor5.0
Rnor_5.04228,738,954 - 228,739,298NCBIRnor5.0
Rnor_5.04228,749,721 - 228,750,093NCBIRnor5.0
Rnor_5.04228,818,510 - 228,818,874NCBIRnor5.0
RGSC_v3.44169,856,985 - 169,857,348RGDRGSC3.4
RGSC_v3.44169,852,986 - 169,853,357RGDRGSC3.4
RGSC_v3.44169,788,156 - 169,788,499RGDRGSC3.4
RGSC_v3.14170,033,092 - 170,033,435RGD
Celera4154,400,662 - 154,401,016UniSTS
Celera4154,335,739 - 154,336,081UniSTS
RH 3.4 Map4995.9RGD
RH 3.4 Map4995.9UniSTS
Cytogenetic Map4q42UniSTS
D4Arb2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera4154,400,714 - 154,401,111UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system renal system reproductive system respiratory system
High
Medium
Low 1 2 2 1
Below cutoff 1 6 11 1 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045884   ⟹   ENSRNOP00000048827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4165,828,456 - 165,832,004 (-)Ensembl
Rnor_6.0 Ensembl4166,222,451 - 166,224,565 (+)Ensembl
RefSeq Acc Id: NM_012632   ⟹   NP_036764
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84167,559,867 - 167,563,414 (-)NCBI
mRatBN7.24165,828,456 - 165,832,004 (-)NCBI
Rnor_6.04166,222,418 - 166,293,492 (+)NCBI
Rnor_5.04228,749,393 - 228,820,151 (+)NCBI
RGSC_v3.44169,850,594 - 169,853,686 (-)RGD
Celera4154,400,333 - 154,403,595 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036764 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42063 (Get FASTA)   NCBI Sequence Viewer  
  EDM01681 (Get FASTA)   NCBI Sequence Viewer  
  EDM01682 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007119.5
  ENSRNOP00000048827
  ENSRNOP00000048827.3
Reference Protein Sequences
RefSeq Acc Id: NP_036764   ⟸   NM_012632
- Peptide Label: precursor
- UniProtKB: Q04105 (UniProtKB/TrEMBL),   F7F912 (UniProtKB/TrEMBL),   F1LV68 (UniProtKB/TrEMBL),   A6IMA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048827   ⟸   ENSRNOT00000045884

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LV68-F1-model_v2 AlphaFold F1LV68 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3413 AgrOrtholog
BioCyc Gene G2FUF-42708 BioCyc
Ensembl Genes ENSRNOG00000028983 Ensembl
  ENSRNOG00000068724 UniProtKB/TrEMBL
  ENSRNOG00000070768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007119.7 UniProtKB/TrEMBL
  ENSRNOT00000045884 ENTREZGENE
  ENSRNOT00000045884.3 UniProtKB/TrEMBL
InterPro Pro-rich UniProtKB/TrEMBL
KEGG Report rno:24687 UniProtKB/TrEMBL
NCBI Gene 24687 ENTREZGENE
PANTHER BASIC SALIVARY PROLINE-RICH PROTEIN 1-RELATED UniProtKB/TrEMBL
  PTHR23203 UniProtKB/TrEMBL
Pfam Pro-rich UniProtKB/TrEMBL
PhenoGen Prp15 PhenoGen
PRINTS PRICHEXTENSN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028983 RatGTEx
  ENSRNOG00000068724 RatGTEx
  ENSRNOG00000070768 RatGTEx
SMART Pro-rich UniProtKB/TrEMBL
UniProt A6IMA7_RAT UniProtKB/TrEMBL
  A6IMA8 ENTREZGENE, UniProtKB/TrEMBL
  F1LV68 ENTREZGENE
  F7F912 ENTREZGENE
  Q04105 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LV68 UniProtKB/TrEMBL
  F7F912 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Prp15  proline-rich protein 15  Prpb  Proline-rich protein, salivary  Symbol and Name updated 629477 APPROVED
2002-06-10 Prpb  Proline-rich protein, salivary      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contain unusual repeating peptide sequences of 14-19 amino acids 633739