Ppp1r26 (protein phosphatase 1, regulatory subunit 26) - Rat Genome Database

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Gene: Ppp1r26 (protein phosphatase 1, regulatory subunit 26) Rattus norvegicus
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Symbol: Ppp1r26
Name: protein phosphatase 1, regulatory subunit 26
RGD ID: 1595050
Description: Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. Orthologous to human PPP1R26 (protein phosphatase 1 regulatory subunit 26); INTERACTS WITH bisphenol A; 2,3',4,4',5-Pentachlorobiphenyl (ortholog); 3,4-methylenedioxymethamphetamine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07051376.1; LOC685398; rCG45515-like; similar to 1A6/DRIM (down-regulated in metastasis) interacting protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ppp1r26-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,179,686 - 32,188,069 (+)NCBIGRCr8
mRatBN7.2311,781,504 - 11,790,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,781,295 - 11,790,073 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.037,032,118 - 7,040,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,035,169 - 7,038,421 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0312,382,947 - 12,391,430 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,439,319 - 7,444,353 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera36,562,270 - 6,571,507 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19389623  


Genomics

Comparative Map Data
Ppp1r26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,179,686 - 32,188,069 (+)NCBIGRCr8
mRatBN7.2311,781,504 - 11,790,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,781,295 - 11,790,073 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.037,032,118 - 7,040,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,035,169 - 7,038,421 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0312,382,947 - 12,391,430 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,439,319 - 7,444,353 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera36,562,270 - 6,571,507 (+)NCBICelera
Cytogenetic Map3p12NCBI
PPP1R26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389135,479,066 - 135,488,892 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9135,479,079 - 135,488,893 (+)EnsemblGRCh38hg38GRCh38
GRCh379138,371,628 - 138,380,738 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369137,511,469 - 137,520,560 (+)NCBINCBI36Build 36hg18NCBI36
Build 349135,597,592 - 135,606,684NCBI
Celera9108,888,779 - 108,897,869 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9107,836,353 - 107,842,565 (+)NCBIHuRef
CHM1_19138,520,166 - 138,529,344 (+)NCBICHM1_1
T2T-CHM13v2.09147,707,139 - 147,716,966 (+)NCBIT2T-CHM13v2.0
Ppp1r26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,336,613 - 28,345,520 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl228,336,812 - 28,345,520 (+)EnsemblGRCm39 Ensembl
GRCm38228,446,493 - 28,455,508 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,446,800 - 28,455,508 (+)EnsemblGRCm38mm10GRCm38
MGSCv37228,303,461 - 28,311,028 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36228,269,950 - 28,277,517 (+)NCBIMGSCv36mm8
Celera228,152,222 - 28,159,789 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.38NCBI
Ppp1r26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,042,763 - 4,046,467 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,039,819 - 4,046,482 (+)NCBIChiLan1.0ChiLan1.0
PPP1R26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,823,768 - 3,838,873 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,826,926 - 3,841,206 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09106,620,368 - 106,629,655 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19135,613,494 - 135,622,218 (+)NCBIpanpan1.1PanPan1.1panPan2
PPP1R26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,196,524 - 51,204,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl951,199,252 - 51,202,800 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha950,492,110 - 50,500,625 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0952,086,793 - 52,094,566 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1950,864,889 - 50,873,413 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,189,397 - 51,197,905 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,269,251 - 51,277,026 (+)NCBIUU_Cfam_GSD_1.0
Ppp1r26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,293,186 - 201,300,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366692,075,659 - 2,079,459 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366692,074,225 - 2,081,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21308,617,637 - 308,624,955 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1122,681,538 - 2,690,589 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl122,682,299 - 2,685,943 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660582,467,025 - 2,476,229 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247603,094,025 - 3,097,699 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247603,090,014 - 3,099,163 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r26
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:60
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000036601
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
RH130832  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2311,789,750 - 11,789,946 (+)MAPPERmRatBN7.2
Rnor_6.037,040,290 - 7,040,485NCBIRnor6.0
Rnor_5.0312,391,105 - 12,391,300UniSTSRnor5.0
RGSC_v3.437,444,028 - 7,444,223UniSTSRGSC3.4
Celera36,571,182 - 6,571,377UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000036601   ⟹   ENSRNOP00000037924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl311,781,295 - 11,790,073 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102380   ⟹   ENSRNOP00000078859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl311,781,632 - 11,790,073 (+)Ensembl
RefSeq Acc Id: NM_001427208   ⟹   NP_001414137
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,179,686 - 32,188,069 (+)NCBI
RefSeq Acc Id: XM_039106146   ⟹   XP_038962074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,179,759 - 32,188,066 (+)NCBI
mRatBN7.2311,781,764 - 11,790,076 (+)NCBI
RefSeq Acc Id: XM_039106149   ⟹   XP_038962077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,179,759 - 32,188,066 (+)NCBI
mRatBN7.2311,781,764 - 11,790,076 (+)NCBI
RefSeq Acc Id: XM_039106150   ⟹   XP_038962078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,179,759 - 32,188,066 (+)NCBI
mRatBN7.2311,781,764 - 11,790,076 (+)NCBI
RefSeq Acc Id: XM_063284559   ⟹   XP_063140629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,180,184 - 32,188,066 (+)NCBI
RefSeq Acc Id: XP_038962078   ⟸   XM_039106150
- Peptide Label: isoform X1
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962077   ⟸   XM_039106149
- Peptide Label: isoform X1
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962074   ⟸   XM_039106146
- Peptide Label: isoform X1
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078859   ⟸   ENSRNOT00000102380
Ensembl Acc Id: ENSRNOP00000037924   ⟸   ENSRNOT00000036601
RefSeq Acc Id: NP_001414137   ⟸   NM_001427208
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140629   ⟸   XM_063284559
- Peptide Label: isoform X1
- UniProtKB: A6JTN0 (UniProtKB/TrEMBL),   D3ZPW4 (UniProtKB/TrEMBL)
Protein Domains
Protein phosphatase 1 regulatory subunit 26 N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPW4-F1-model_v2 AlphaFold D3ZPW4 1-956 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595050 AgrOrtholog
BioCyc Gene G2FUF-50283 BioCyc
Ensembl Genes ENSRNOG00000027193 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036601.5 UniProtKB/TrEMBL
  ENSRNOT00000102380.1 UniProtKB/TrEMBL
InterPro PPP1R26 UniProtKB/TrEMBL
  PPP1R26_N UniProtKB/TrEMBL
NCBI Gene 685398 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 26 UniProtKB/TrEMBL
  PTHR15724 UniProtKB/TrEMBL
Pfam PPP1R26_N UniProtKB/TrEMBL
PhenoGen Ppp1r26 PhenoGen
RatGTEx ENSRNOG00000027193 RatGTEx
UniProt A6JTN0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPW4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ppp1r26  protein phosphatase 1, regulatory subunit 26  AABR07051376.1    Data merged from RGD:15003656 737654 PROVISIONAL
2019-11-08 AABR07051376.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-05-24 Ppp1r26  protein phosphatase 1, regulatory subunit 26  LOC100364681  rCG45515-like  Data merged from RGD:2320582 1643240 APPROVED
2011-10-21 Ppp1r26  protein phosphatase 1, regulatory subunit 26  LOC685398  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100364681  rCG45515-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC685398  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein  LOC687551  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein  Data merged from RGD:1584214 1643240 APPROVED
2006-11-20 LOC685398  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687551  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein      Symbol and Name status set to provisional 70820 PROVISIONAL