Mageb3 (MAGE family member B3) - Rat Genome Database

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Gene: Mageb3 (MAGE family member B3) Rattus norvegicus
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Symbol: Mageb3
Name: MAGE family member B3
RGD ID: 1562343
Description: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human MAGEB3 (MAGE family member B3); INTERACTS WITH bisphenol A; furan; methamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC302746; melanoma antigen family B, 3; melanoma-associated antigen B3; RGD1562343; similar to Melanoma-associated antigen B3 (MAGE-B3 antigen)
RGD Orthologs
Human
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X54,816,254 - 54,817,249 (-)NCBIGRCr8
mRatBN7.2X50,865,484 - 50,866,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX50,865,484 - 50,866,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX52,195,173 - 52,196,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X55,695,585 - 55,696,580 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X53,326,558 - 53,327,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X54,843,202 - 54,844,197 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX54,843,096 - 54,844,197 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X55,046,586 - 55,047,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X73,114,968 - 73,115,963 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX51,398,522 - 51,399,517 (-)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Mageb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X54,816,254 - 54,817,249 (-)NCBIGRCr8
mRatBN7.2X50,865,484 - 50,866,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX50,865,484 - 50,866,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX52,195,173 - 52,196,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X55,695,585 - 55,696,580 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X53,326,558 - 53,327,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X54,843,202 - 54,844,197 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX54,843,096 - 54,844,197 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X55,046,586 - 55,047,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X73,114,968 - 73,115,963 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX51,398,522 - 51,399,517 (-)NCBICelera
Cytogenetic MapXq21NCBI
MAGEB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X30,230,657 - 30,237,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX30,230,657 - 30,237,495 (+)EnsemblGRCh38hg38GRCh38
GRCh37X30,248,774 - 30,255,612 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X30,158,474 - 30,165,528 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X30,008,209 - 30,015,264NCBI
CeleraX34,370,173 - 34,377,229 (+)NCBICelera
Cytogenetic MapXp21.2NCBI
HuRefX27,985,506 - 27,992,557 (+)NCBIHuRef
CHM1_1X30,279,495 - 30,286,489 (+)NCBICHM1_1
T2T-CHM13v2.0X29,823,006 - 29,829,848 (+)NCBIT2T-CHM13v2.0
MAGEB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X32,029,051 - 32,031,857 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X32,032,430 - 32,035,236 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X22,820,432 - 22,837,556 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X30,391,137 - 30,392,631 (+)NCBIpanpan1.1PanPan1.1panPan2
MAGEB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X25,341,792 - 25,343,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX30,310,965 - 30,315,213 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X25,359,104 - 25,363,133 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X25,407,146 - 25,411,395 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X25,404,825 - 25,409,066 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X25,500,674 - 25,504,922 (+)NCBIUU_Cfam_GSD_1.0
MAGEB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX26,053,954 - 26,054,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X26,044,502 - 26,055,412 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X28,310,444 - 28,321,659 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAGEB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X28,635,826 - 28,641,082 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX28,638,431 - 28,639,471 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605630,619,498 - 30,624,748 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:115
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000044910
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

reproductive system
28

Sequence


Ensembl Acc Id: ENSRNOT00000044910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX50,865,484 - 50,866,479 (-)Ensembl
Rnor_6.0 EnsemblX54,843,096 - 54,844,197 (-)Ensembl
RefSeq Acc Id: NM_001106965   ⟹   NP_001100435
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,816,254 - 54,817,249 (-)NCBI
mRatBN7.2X50,865,484 - 50,866,479 (-)NCBI
Rnor_6.0X54,843,202 - 54,844,197 (-)NCBI
Rnor_5.0X55,046,586 - 55,047,581 (-)NCBI
RGSC_v3.4X73,114,968 - 73,115,963 (-)RGD
CeleraX51,398,522 - 51,399,517 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96043 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093294.1
RefSeq Acc Id: NP_001100435   ⟸   NM_001106965
- UniProtKB: A0A8I6AWU5 (UniProtKB/TrEMBL),   A6IPX0 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
MAGE

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562343 AgrOrtholog
BioCyc Gene G2FUF-2336 BioCyc
Ensembl Genes ENSRNOG00000038269 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044910.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
InterPro MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
  MHD_dom UniProtKB/TrEMBL
KEGG Report rno:302746 UniProtKB/TrEMBL
NCBI Gene 302746 ENTREZGENE
PANTHER MELANOMA-ASSOCIATED ANTIGEN B3 UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
PhenoGen Mageb3 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038269 RatGTEx
SMART MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
UniProt A0A8I6AWU5 ENTREZGENE, UniProtKB/TrEMBL
  A6IPX0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Mageb3  MAGE family member B3  Mageb3  melanoma antigen family B, 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Mageb3  melanoma antigen family B, 3  RGD1562343_predicted  similar to Melanoma-associated antigen B3 (MAGE-B3 antigen) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562343_predicted  similar to Melanoma-associated antigen B3 (MAGE-B3 antigen) (predicted)  LOC302746  similar to Melanoma-associated antigen B3 (MAGE-B3 antigen)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302746  similar to Melanoma-associated antigen B3 (MAGE-B3 antigen)      Symbol and Name status set to provisional 70820 PROVISIONAL