Defa7 (defensin alpha 7) - Rat Genome Database

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Gene: Defa7 (defensin alpha 7) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Defa7 (Ensembl: Np4)
Name: defensin alpha 7 (Ensembl:defensin NP-4 precursor)
RGD ID: 1560529
Description: Predicted to be involved in defense response to bacterium; defense response to fungus; and killing of cells of another organism. Predicted to be located in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-defensin 7
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,121,608 - 77,133,013 (-)NCBIGRCr8
mRatBN7.21670,419,152 - 70,430,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,419,277 - 70,420,046 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,692,984 - 75,693,753 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,146,396 - 79,147,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,395,818 - 74,396,587 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,414,786 - 75,415,555 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01675,029,574 - 75,030,343 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,101,479 - 75,102,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,291,841 - 68,292,610 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Defa7
199 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:58
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000029297
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000029297   ⟹   ENSRNOP00000037267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,419,277 - 70,420,046 (-)Ensembl
RefSeq Acc Id: NR_172012
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,121,608 - 77,133,013 (-)NCBI
mRatBN7.21670,419,152 - 70,430,555 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001028247 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT68750 (Get FASTA)   NCBI Sequence Viewer  
  AAT68758 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037267.3
Ensembl Acc Id: ENSRNOP00000037267   ⟸   ENSRNOT00000029297
Protein Domains
Mammalian defensins

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560529 AgrOrtholog
BioCyc Gene G2FUF-10832 BioCyc
Ensembl Genes ENSRNOG00000028707 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029297.4 UniProtKB/TrEMBL
InterPro Alpha-defensin UniProtKB/TrEMBL
  Defensin_beta/neutrophil UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
  Mammalian_defensins UniProtKB/TrEMBL
NCBI Gene 613222 ENTREZGENE
PANTHER DEFENSIN ALPHA 10-RELATED UniProtKB/TrEMBL
  PTHR11876 UniProtKB/TrEMBL
Pfam Defensin_1 UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
PhenoGen Defa7 PhenoGen
PIRSF Alpha-defensin UniProtKB/TrEMBL
PROSITE DEFENSIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028707 RatGTEx
SMART Defensin_propep UniProtKB/TrEMBL
  DEFSN UniProtKB/TrEMBL
Superfamily-SCOP Defensin-like UniProtKB/TrEMBL
UniProt F1LQB7 ENTREZGENE, UniProtKB/TrEMBL
  Q4JEI7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Defa7  defensin alpha 7      Symbol and Name status set to provisional 70820 PROVISIONAL