PREP (prolyl endopeptidase) - Rat Genome Database

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Gene: PREP (prolyl endopeptidase) Sus scrofa
Analyze
Symbol: PREP
Name: prolyl endopeptidase
RGD ID: 14297949
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); peptide binding (ortholog); INVOLVED IN protein catabolic process (ortholog); ASSOCIATED WITH amnestic disorder (ortholog); depressive disorder (ortholog); Disease Progression (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PE; post-proline cleaving enzyme
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,496,306 - 71,636,747 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1171,496,299 - 72,027,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2180,817,291 - 80,892,385 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISS)
cytosol  (IEA)
extracellular region  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:1900195   PMID:2064618   PMID:9695945   PMID:14681463   PMID:17145712   PMID:22132071   PMID:22301074   PMID:27434808   PMID:30032202  


Genomics

Comparative Map Data
PREP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,496,306 - 71,636,747 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1171,496,299 - 72,027,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2180,817,291 - 80,892,385 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PREP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386105,273,218 - 105,403,082 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6105,273,218 - 105,454,062 (-)Ensemblhg38GRCh38
GRCh376105,721,093 - 105,850,957 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366105,832,199 - 105,957,662 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346105,832,198 - 105,957,662NCBI
Celera6106,347,577 - 106,473,093 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6103,168,797 - 103,294,318 (-)NCBIHuRef
CHM1_16105,987,432 - 106,112,999 (-)NCBICHM1_1
T2T-CHM13v2.06106,448,949 - 106,578,910 (-)NCBIT2T-CHM13v2.0
Prep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391044,943,312 - 45,038,847 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1044,943,299 - 45,043,294 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381045,067,216 - 45,162,751 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1045,067,203 - 45,167,198 (+)Ensemblmm10GRCm38
MGSCv371044,787,020 - 44,878,801 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361044,755,629 - 44,847,410 (+)NCBIMGSCv36mm8
Celera1045,941,173 - 46,032,935 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.27NCBI
Prep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82050,138,588 - 50,235,549 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2050,131,819 - 50,252,697 (+)EnsemblGRCr8
mRatBN7.22048,556,211 - 48,653,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2048,556,280 - 48,654,466 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2050,300,058 - 50,395,795 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02049,949,970 - 50,045,703 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02050,634,121 - 50,729,857 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2050,177,812 - 50,274,007 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive2051,242,564 - 51,338,800 (+)NCBILyon_Normotensive
Lyon_Hypertensive2051,307,377 - 51,403,571 (+)NCBILyon_Hypertensive
F344_StmMcwi2050,127,007 - 50,223,180 (+)NCBIF344_StmMcwi
Rnor_6.02050,172,618 - 50,269,992 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2050,172,618 - 50,269,992 (+)Ensemblrn6Rnor6.0
Rnor_5.02051,789,200 - 51,885,778 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42049,024,917 - 49,144,670 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2051,366,123 - 51,463,044 (-)NCBICelera
RGSC_v3.12049,053,613 - 49,173,367 (+)NCBI
Cytogenetic Map20q13NCBI
Prep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541130,698,112 - 30,835,923 (-)Ensembl
ChiLan1.0NW_00495541130,698,112 - 30,797,096 (-)NCBIChiLan1.0ChiLan1.0
PREP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25125,296,938 - 125,425,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16123,183,455 - 123,311,849 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06103,091,315 - 103,219,335 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16106,965,275 - 107,093,091 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6106,965,275 - 107,091,278 (-)EnsemblpanPan2panpan1.1
PREP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11262,709,158 - 62,821,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1262,709,434 - 62,829,084 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1262,497,580 - 62,615,079 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01263,560,860 - 63,678,389 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1263,560,878 - 63,680,592 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11262,915,128 - 63,032,788 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01262,756,480 - 62,874,410 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01263,035,919 - 63,153,927 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494697,669,412 - 97,787,348 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365641,944,245 - 2,062,262 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365641,944,245 - 2,062,178 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11368,406,298 - 68,536,166 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1368,406,452 - 68,536,234 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604040,749,136 - 40,882,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624952502,274 - 620,943 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624952504,943 - 620,968 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prep
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11844,838,582 - 44,933,683 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in PREP
12560 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000004829   ⟹   ENSSSCP00000004715
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl171,496,310 - 71,636,747 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000039770   ⟹   ENSSSCP00000049709
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl171,495,194 - 71,701,093 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000055168   ⟹   ENSSSCP00000042303
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl171,496,306 - 71,636,109 (-)Ensembl
RefSeq Acc Id: NM_001004050   ⟹   NP_001004050
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1171,496,590 - 71,636,145 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083601   ⟹   XP_020939260
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1171,496,299 - 72,027,308 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001004050 (Get FASTA)   NCBI Sequence Viewer  
  XP_020939260 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA31110 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000004715
  ENSSSCP00000004715.4
  ENSSSCP00055020588.1
  ENSSSCP00115000680
GenBank Protein P23687 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_020939260   ⟸   XM_021083601
- Peptide Label: isoform X1
- UniProtKB: A0A287AZX9 (UniProtKB/TrEMBL),   A0A8D1THB8 (UniProtKB/TrEMBL),   A0A8D0YAH7 (UniProtKB/TrEMBL),   A0A8D1XIU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001004050   ⟸   NM_001004050
- UniProtKB: P23687 (UniProtKB/Swiss-Prot),   A0A480WGK4 (UniProtKB/TrEMBL),   A0A8D0RK02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000049709   ⟸   ENSSSCT00000039770
Ensembl Acc Id: ENSSSCP00000042303   ⟸   ENSSSCT00000055168
Ensembl Acc Id: ENSSSCP00000004715   ⟸   ENSSSCT00000004829
Protein Domains
Peptidase S9 prolyl oligopeptidase catalytic   Peptidase S9A N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004368 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00055013045 UniProtKB/Swiss-Prot
  ENSSSCG00115000498 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000004829 ENTREZGENE
  ENSSSCT00000004829.5 UniProtKB/Swiss-Prot
  ENSSSCT00055025909.1 UniProtKB/Swiss-Prot
  ENSSSCT00115000742 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
  Prolyl oligopeptidase, N-terminal domain UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Pept_S9_AS UniProtKB/Swiss-Prot
  Pept_S9A_N UniProtKB/Swiss-Prot
  Peptidase_S9 UniProtKB/Swiss-Prot
  Peptidase_S9A UniProtKB/Swiss-Prot
  Prolyl_oligopep/macrocyclase UniProtKB/Swiss-Prot
KEGG Report ssc:445540 UniProtKB/Swiss-Prot
NCBI Gene PREP ENTREZGENE
PANTHER PROLYL ENDOPEPTIDASE UniProtKB/Swiss-Prot
  PROLYL ENDOPEPTIDASE UniProtKB/Swiss-Prot
Pfam Peptidase_S9 UniProtKB/Swiss-Prot
  Peptidase_S9_N UniProtKB/Swiss-Prot
PRINTS PROLIGOPTASE UniProtKB/Swiss-Prot
PROSITE PRO_ENDOPEP_SER UniProtKB/Swiss-Prot
Superfamily-SCOP Peptidase/esterase 'gauge' domain UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
UniProt A0A287AZX9 ENTREZGENE
  A0A480WGK4 ENTREZGENE, UniProtKB/TrEMBL
  A0A5S6HMR6_PIG UniProtKB/TrEMBL
  A0A8D0RK02 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0YAH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CYT0_PIG UniProtKB/TrEMBL
  A0A8D1HKT2_PIG UniProtKB/TrEMBL
  A0A8D1QGF2_PIG UniProtKB/TrEMBL
  A0A8D1THB8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1XGD3_PIG UniProtKB/TrEMBL
  A0A8D1XIU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2BZ85_PIG UniProtKB/TrEMBL
  P23687 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:103157 ENTREZGENE