MVD (mevalonate diphosphate decarboxylase) - Rat Genome Database

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Gene: MVD (mevalonate diphosphate decarboxylase) Sus scrofa
Analyze
Symbol: MVD
Name: mevalonate diphosphate decarboxylase
RGD ID: 13962403
Description: ENCODES a protein that exhibits diphosphomevalonate decarboxylase activity (ortholog); INVOLVED IN isopentenyl diphosphate biosynthetic process, mevalonate pathway (ortholog); response to xenobiotic stimulus (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH Hypercholesterolemia (ortholog); porokeratosis (ortholog); Porokeratosis 7, Multiple Types (ortholog); FOUND IN peroxisomal matrix (ortholog); peroxisome (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: diphosphomevalonate decarboxylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,008,100 - 1,014,303 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.161,008,100 - 1,014,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA)
peroxisomal matrix  (ISO)
peroxisome  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MVD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,008,100 - 1,014,303 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.161,008,100 - 1,014,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MVD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,651,940 - 88,663,091 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,651,934 - 88,663,161 (-)Ensemblhg38GRCh38
GRCh371688,718,348 - 88,729,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,245,849 - 87,256,996 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341687,245,848 - 87,256,996NCBI
Celera1673,788,020 - 73,799,160 (-)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1674,412,379 - 74,423,531 (-)NCBIHuRef
CHM1_11690,129,698 - 90,140,847 (-)NCBICHM1_1
T2T-CHM13v2.01694,719,870 - 94,731,025 (-)NCBIT2T-CHM13v2.0
Mvd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,160,335 - 123,170,161 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,160,340 - 123,170,161 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388122,433,596 - 122,443,422 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,433,601 - 122,443,422 (-)Ensemblmm10GRCm38
MGSCv378124,957,496 - 124,967,322 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368125,319,694 - 125,329,480 (-)NCBIMGSCv36mm8
Celera8126,662,705 - 126,672,531 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.05NCBI
Mvd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,404,911 - 67,414,974 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1967,404,911 - 67,422,366 (-)EnsemblGRCr8
mRatBN7.21950,496,366 - 50,506,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,496,367 - 50,507,971 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1957,291,544 - 57,301,618 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,971,299 - 57,981,362 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,190,162 - 60,200,236 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1961,203,181 - 61,213,255 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1959,325,866 - 59,335,929 (-)NCBILyon_Normotensive
Lyon_Hypertensive1961,199,328 - 61,209,391 (-)NCBILyon_Hypertensive
F344_StmMcwi1958,934,305 - 58,944,379 (-)NCBIF344_StmMcwi
Rnor_6.01955,258,910 - 55,268,933 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,258,905 - 55,268,951 (-)Ensemblrn6Rnor6.0
Rnor_5.01965,967,921 - 65,978,403 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41952,722,306 - 52,732,312 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1949,735,851 - 49,745,874 (-)NCBICelera
RGSC_v3.11952,727,186 - 52,737,193 (-)NCBI
Cytogenetic Map19q12NCBI
Mvd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,579,074 - 2,581,821 (-)Ensembl
ChiLan1.0NW_0049555412,578,584 - 2,581,823 (-)NCBIChiLan1.0ChiLan1.0
MVD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21898,425,011 - 98,436,132 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,337,122 - 104,348,237 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,365,070 - 69,376,149 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,025,571 - 89,036,975 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,025,572 - 89,036,964 (-)EnsemblpanPan2panpan1.1
MVD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,683,146 - 64,691,576 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,682,276 - 64,691,073 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha564,693,894 - 64,702,261 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0564,902,561 - 64,910,915 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,902,588 - 64,910,915 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,928,745 - 64,937,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,760,442 - 64,768,801 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,166,481 - 65,174,835 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mvd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,275,679 - 25,282,419 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366411,030,595 - 1,035,954 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366411,030,465 - 1,035,967 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MVD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,031,470 - 74,049,066 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,031,316 - 74,049,011 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660471,646,023 - 1,653,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mvd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746905,757 - 911,591 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624746905,919 - 911,591 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mvd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11742,073,235 - 42,083,429 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in MVD
88 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000048322   ⟹   ENSSSCP00000041035
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl61,008,100 - 1,014,302 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000061448   ⟹   ENSSSCP00000037983
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl61,009,687 - 1,014,303 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000095889   ⟹   ENSSSCP00000074883
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl61,009,824 - 1,014,303 (+)Ensembl
RefSeq Acc Id: XM_021093666   ⟹   XP_020949325
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.161,008,106 - 1,014,303 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002344443
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.161,008,100 - 1,014,261 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020949325   ⟸   XM_021093666
- UniProtKB: A0A287AB49 (UniProtKB/TrEMBL),   A0A4X1T9M8 (UniProtKB/TrEMBL),   A0A8D1FF34 (UniProtKB/TrEMBL),   A0A8D1ZTP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000037983   ⟸   ENSSSCT00000061448
Ensembl Acc Id: ENSSSCP00000041035   ⟸   ENSSSCT00000048322
Ensembl Acc Id: ENSSSCP00000074883   ⟸   ENSSSCT00000095889
Protein Domains
Diphosphomevalonate decarboxylase-like N-terminal   Mvd1 C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034905 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015033983 UniProtKB/TrEMBL
  ENSSSCG00025020401 UniProtKB/TrEMBL
  ENSSSCG00030065567 UniProtKB/TrEMBL
  ENSSSCG00035032142 UniProtKB/TrEMBL
  ENSSSCG00040062238 UniProtKB/TrEMBL
  ENSSSCG00045011149 UniProtKB/TrEMBL
  ENSSSCG00050040012 UniProtKB/TrEMBL
  ENSSSCG00055007603 UniProtKB/TrEMBL
  ENSSSCG00060036981 UniProtKB/TrEMBL
  ENSSSCG00065065860 UniProtKB/TrEMBL
  ENSSSCG00070007585 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048322 ENTREZGENE
  ENSSSCT00000048322.1 UniProtKB/TrEMBL
  ENSSSCT00000061448.3 UniProtKB/TrEMBL
  ENSSSCT00000095889.1 UniProtKB/TrEMBL
  ENSSSCT00015045006.1 UniProtKB/TrEMBL
  ENSSSCT00025027698.1 UniProtKB/TrEMBL
  ENSSSCT00025027731.1 UniProtKB/TrEMBL
  ENSSSCT00030091602.1 UniProtKB/TrEMBL
  ENSSSCT00030091622.1 UniProtKB/TrEMBL
  ENSSSCT00035042573.1 UniProtKB/TrEMBL
  ENSSSCT00035042583.1 UniProtKB/TrEMBL
  ENSSSCT00040084748.1 UniProtKB/TrEMBL
  ENSSSCT00040084844.1 UniProtKB/TrEMBL
  ENSSSCT00045018940.1 UniProtKB/TrEMBL
  ENSSSCT00045019008.1 UniProtKB/TrEMBL
  ENSSSCT00050054052.1 UniProtKB/TrEMBL
  ENSSSCT00050054060.1 UniProtKB/TrEMBL
  ENSSSCT00055014815.1 UniProtKB/TrEMBL
  ENSSSCT00055014889.1 UniProtKB/TrEMBL
  ENSSSCT00060050097.1 UniProtKB/TrEMBL
  ENSSSCT00065090382.1 UniProtKB/TrEMBL
  ENSSSCT00065090395.1 UniProtKB/TrEMBL
  ENSSSCT00070014654.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.10 UniProtKB/TrEMBL
  3.30.70.890 UniProtKB/TrEMBL
InterPro GHMP_kinase_C_sf UniProtKB/TrEMBL
  Mev_decarb UniProtKB/TrEMBL
  Mev_diP_decarb UniProtKB/TrEMBL
  MVD-like_N UniProtKB/TrEMBL
  Mvd1_C UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
NCBI Gene MVD ENTREZGENE
PANTHER DIPHOSPHOMEVALONATE DECARBOXYLASE UniProtKB/TrEMBL
  DIPHOSPHOMEVALONATE DECARBOXYLASE UniProtKB/TrEMBL
Pfam MDD_C UniProtKB/TrEMBL
  MVD-like_N UniProtKB/TrEMBL
PIRSF Mev_P_decrbx UniProtKB/TrEMBL
Superfamily-SCOP SSF54211 UniProtKB/TrEMBL
  SSF55060 UniProtKB/TrEMBL
UniProt A0A287A225_PIG UniProtKB/TrEMBL
  A0A287AB49 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T9M8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NGB0_PIG UniProtKB/TrEMBL
  A0A8D0R4V4_PIG UniProtKB/TrEMBL
  A0A8D0R772_PIG UniProtKB/TrEMBL
  A0A8D0XVE7_PIG UniProtKB/TrEMBL
  A0A8D0XYQ6_PIG UniProtKB/TrEMBL
  A0A8D1FF34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1MDT3_PIG UniProtKB/TrEMBL
  A0A8D1MH95_PIG UniProtKB/TrEMBL
  A0A8D1Q3H3_PIG UniProtKB/TrEMBL
  A0A8D1V9D5_PIG UniProtKB/TrEMBL
  A0A8D1ZTP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2CEJ5_PIG UniProtKB/TrEMBL
  A0A8W4F6U2_PIG UniProtKB/TrEMBL
  M3VH72_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90489 ENTREZGENE