Sfnl1 (stratifin like 1) - Rat Genome Database

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Gene: Sfnl1 (stratifin like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Sfnl1
Name: stratifin like 1
RGD ID: 1359510
Description: Predicted to enable protein kinase binding activity. Predicted to be involved in intracellular protein localization and signal transduction. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin); INTERACTS WITH triticonazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14-3-3 protein sigma-like; hypothetical protein LOC298795; LOC298795; MGC108952; similar to 14-3-3 protein sigma; uncharacterized protein LOC298795
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8628,716,918 - 28,718,201 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl628,715,325 - 28,718,620 (-)EnsemblGRCr8
mRatBN7.2622,965,151 - 22,966,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl622,965,093 - 22,966,452 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx623,296,519 - 23,297,802 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0623,612,342 - 23,613,625 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0623,099,999 - 23,101,273 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd630,164,711 - 30,165,994 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive629,601,233 - 29,602,516 (-)NCBILyon_Normotensive
Lyon_Hypertensive627,397,079 - 27,398,362 (-)NCBILyon_Hypertensive
F344_StmMcwi626,609,186 - 26,610,469 (-)NCBIF344_StmMcwi
Rnor_6.0623,757,225 - 23,758,508 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl623,757,225 - 23,758,496 (+)Ensemblrn6Rnor6.0
Rnor_5.0633,617,273 - 33,618,556 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4623,095,404 - 23,096,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera622,499,765 - 22,500,992 (-)NCBICelera
RGSC_v3.1623,098,367 - 23,099,639 (-)NCBI
Cytogenetic Map6q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17303654  


Genomics

Variants

.
Variants in Sfnl1
4 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)62328466429732046Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
DXRat56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X58,753,434 - 58,753,614 (+)MAPPERmRatBN7.2
Rnor_6.0X63,109,746 - 63,109,925NCBIRnor6.0
Rnor_5.0X63,699,539 - 63,699,718UniSTSRnor5.0
RGSC_v3.4X81,378,219 - 81,378,398UniSTSRGSC3.4
RGSC_v3.4X81,378,218 - 81,378,398RGDRGSC3.4
CeleraX59,189,648 - 59,189,827UniSTS
RGSC_v3.1X81,451,511 - 81,451,690RGD
RH 3.4 Map41029.5RGD
RH 3.4 Map41029.5UniSTS
FHH x ACI MapX21.8699RGD
FHH x ACI MapX21.8699UniSTS
Cytogenetic MapXq31UniSTS
Cytogenetic Map6q13UniSTS
RH135032  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q13UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 54 114 86 85 54 31 54 6 232 107 94 49 64 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000005553   ⟹   ENSRNOP00000066315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl628,715,325 - 28,718,620 (-)Ensembl
mRatBN7.2 Ensembl622,965,093 - 22,966,452 (-)Ensembl
Rnor_6.0 Ensembl623,757,225 - 23,758,496 (+)Ensembl
RefSeq Acc Id: NM_001013941   ⟹   NP_001013963
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8628,716,918 - 28,718,201 (-)NCBI
mRatBN7.2622,965,151 - 22,966,436 (-)NCBI
Dahl_SR_JrHsd630,164,711 - 30,165,994 (-)NCBI
Lyon_Normotensive629,601,233 - 29,602,516 (-)NCBI
Lyon_Hypertensive627,397,079 - 27,398,362 (-)NCBI
F344_StmMcwi626,609,186 - 26,610,469 (-)NCBI
Rnor_6.0623,757,225 - 23,758,508 (+)NCBI
Rnor_5.0633,617,273 - 33,618,556 (+)NCBI
RGSC_v3.4623,095,404 - 23,096,686 (-)RGD
Celera622,499,765 - 22,500,992 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013963 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79389 (Get FASTA)   NCBI Sequence Viewer  
  AAH89860 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066315
  ENSRNOP00000066315.1
RefSeq Acc Id: NP_001013963   ⟸   NM_001013941
- UniProtKB: Q5EBB0 (UniProtKB/TrEMBL),   Q68FS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066315   ⟸   ENSRNOT00000005553
Protein Domains
14-3-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5EBB0-F1-model_v2 AlphaFold Q5EBB0 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694420
Promoter ID:EPDNEW_R4945
Type:multiple initiation site
Name:LOC298795_1
Description:similar to 14-3-3 protein sigma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0623,757,198 - 23,757,258EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359510 AgrOrtholog
BioCyc Gene G2FUF-38398 BioCyc
Ensembl Genes ENSRNOG00000004188 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005553 ENTREZGENE
  ENSRNOT00000005553.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.190.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111773 IMAGE-MGC_LOAD
  IMAGE:7112967 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/TrEMBL
  14-3-3_sigma UniProtKB/TrEMBL
KEGG Report rno:298795 UniProtKB/TrEMBL
MGC_CLONE MGC:108952 IMAGE-MGC_LOAD
  MGC:94904 IMAGE-MGC_LOAD
NCBI Gene 298795 ENTREZGENE
PANTHER 14-3-3 UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/TrEMBL
PhenoGen Sfnl1 PhenoGen
PIRSF 14-3-3 UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/TrEMBL
  1433_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004188 RatGTEx
SMART 14_3_3 UniProtKB/TrEMBL
Superfamily-SCOP 14-3-3 UniProtKB/TrEMBL
UniProt Q5EBB0 ENTREZGENE, UniProtKB/TrEMBL
  Q68FS0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-28 Sfnl1  stratifin like 1  LOC298795  similar to 14-3-3 protein sigma  Name and Symbol changed 629549 APPROVED
2005-07-29 LOC298795  similar to 14-3-3 protein sigma      Symbol and Name status set to provisional 70820 PROVISIONAL