P2RY2 (purinergic receptor P2Y2) - Rat Genome Database

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Gene: P2RY2 (purinergic receptor P2Y2) Homo sapiens
Analyze
Symbol: P2RY2
Name: purinergic receptor P2Y2
RGD ID: 1352486
HGNC Page HGNC
Description: Predicted to have A1 adenosine receptor binding activity. Predicted to be involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Predicted to localize to glutamatergic synapse and integral component of presynaptic active zone membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP receptor; HP2U; MGC20088; MGC40010; P2RU1; P2U; P2U nucleotide receptor; P2U purinoceptor 1; P2U receptor 1; P2U1; P2UR; P2Y purinoceptor 2; P2Y2; P2Y2R; purinergic receptor P2Y, G-protein coupled, 2; purinoceptor P2Y2; RP11-800A3.4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: GPR79  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1173,218,298 - 73,236,352 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1173,218,281 - 73,242,427 (+)EnsemblGRCh38hg38GRCh38
GRCh381173,200,416 - 73,246,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,929,326 - 72,953,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,606,992 - 72,625,045 (+)NCBINCBI36hg18NCBI36
Build 341172,606,991 - 72,625,041NCBI
Celera1170,233,951 - 70,251,998 (+)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1169,224,261 - 69,248,426 (+)NCBIHuRef
CHM1_11172,813,103 - 72,837,239 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
ATP  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (EXP)
cyclophosphamide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP,ISO)
ethanol  (ISO)
fenamidone  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
furan  (ISO)
glycidol  (ISO)
Goe 6976  (ISO)
hydrogen sulfide  (ISO)
ibuprofen  (EXP)
L-methionine  (ISO)
methamphetamine  (ISO)
methylmercury(1+)  (ISO)
N-(3-oxododecanoyl)homoserine lactone  (EXP)
nickel atom  (EXP)
nickel dichloride  (ISO)
paracetamol  (ISO)
pentanal  (EXP)
phenformin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (EXP)
quercetin  (EXP)
rotenone  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP)
sulforaphane  (EXP)
suramin  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (EXP)
UTP  (EXP,ISO)
valproic acid  (EXP)
vanadyl sulfate  (EXP)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:7779087   PMID:7809171   PMID:8159738   PMID:8248130   PMID:8643996   PMID:9211988   PMID:9286708   PMID:9489506   PMID:9535005   PMID:10770202   PMID:11331301   PMID:11690642  
PMID:12151016   PMID:12477932   PMID:12603858   PMID:12691958   PMID:12714597   PMID:12787128   PMID:12880424   PMID:14613890   PMID:14645014   PMID:14670955   PMID:14702039   PMID:15175347  
PMID:15489334   PMID:15590415   PMID:15778502   PMID:15908695   PMID:16186116   PMID:16311903   PMID:16495779   PMID:16543499   PMID:16545868   PMID:16741950   PMID:16754659   PMID:17137217  
PMID:17170310   PMID:17186500   PMID:17302398   PMID:17452627   PMID:17599409   PMID:17609252   PMID:18240029   PMID:18434089   PMID:18475022   PMID:18506388   PMID:18568944   PMID:18577758  
PMID:19118095   PMID:19419204   PMID:19634190   PMID:19710694   PMID:19734210   PMID:19735076   PMID:19763137   PMID:19797825   PMID:19808895   PMID:19836435   PMID:19900397   PMID:19913121  
PMID:19996104   PMID:20022380   PMID:20056178   PMID:20064929   PMID:20089844   PMID:20427708   PMID:20628086   PMID:20630102   PMID:20880147   PMID:21356271   PMID:21414662   PMID:21651910  
PMID:21652710   PMID:21832049   PMID:21859844   PMID:22521508   PMID:22658674   PMID:22718344   PMID:22753942   PMID:22754043   PMID:22773251   PMID:22993317   PMID:23088987   PMID:23462325  
PMID:23517042   PMID:23757023   PMID:23810565   PMID:24095926   PMID:24193664   PMID:24390819   PMID:24486339   PMID:24491917   PMID:24631773   PMID:24716914   PMID:24847054   PMID:24961145  
PMID:25003238   PMID:25156554   PMID:25238333   PMID:25575516   PMID:25657827   PMID:25713410   PMID:25807824   PMID:25937122   PMID:26063340   PMID:26168216   PMID:26182292   PMID:26443721  
PMID:26631725   PMID:26663301   PMID:26996596   PMID:27129210   PMID:27250983   PMID:27652381   PMID:27807254   PMID:27977904   PMID:28209512   PMID:28415591   PMID:28923792   PMID:28986522  
PMID:29115551   PMID:29954144   PMID:30226596   PMID:30236981   PMID:30333139   PMID:30420446   PMID:31278420   PMID:31481624   PMID:31553908   PMID:32397236   PMID:32814053  


Genomics

Comparative Map Data
P2RY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1173,218,298 - 73,236,352 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1173,218,281 - 73,242,427 (+)EnsemblGRCh38hg38GRCh38
GRCh381173,200,416 - 73,246,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,929,326 - 72,953,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,606,992 - 72,625,045 (+)NCBINCBI36hg18NCBI36
Build 341172,606,991 - 72,625,041NCBI
Celera1170,233,951 - 70,251,998 (+)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1169,224,261 - 69,248,426 (+)NCBIHuRef
CHM1_11172,813,103 - 72,837,239 (+)NCBICHM1_1
P2ry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,645,775 - 100,661,260 (-)NCBIGRCm39mm39
GRCm39 Ensembl7100,645,775 - 100,662,073 (-)Ensembl
GRCm387100,996,568 - 101,012,053 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,996,568 - 101,012,866 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,145,086 - 108,160,505 (-)NCBIGRCm37mm9NCBIm37
MGSCv367100,870,659 - 100,886,078 (-)NCBImm8
Celera7101,348,339 - 101,363,985 (-)NCBICelera
Cytogenetic Map7E2NCBI
P2ry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,352,050 - 155,367,423 (-)NCBI
Rnor_6.0 Ensembl1166,031,272 - 166,037,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01166,031,228 - 166,045,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01172,227,726 - 172,241,921 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,440,018 - 158,454,213 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,519,034 - 158,533,227 (-)NCBI
Celera1153,434,723 - 153,448,921 (-)NCBICelera
Cytogenetic Map1q32NCBI
P2ry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,248,082 - 18,260,450 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,248,082 - 18,271,047 (-)NCBIChiLan1.0ChiLan1.0
P2RY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11171,517,063 - 71,541,109 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,532,958 - 71,534,091 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01168,294,366 - 68,319,118 (+)NCBIMhudiblu_PPA_v0panPan3
P2RY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,987,568 - 25,009,754 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,992,848 - 24,996,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,753,351 - 24,793,458 (-)NCBI
ROS_Cfam_1.02125,195,604 - 25,235,719 (-)NCBI
UMICH_Zoey_3.12124,989,138 - 25,029,222 (-)NCBI
UNSW_CanFamBas_1.02125,190,157 - 25,231,835 (-)NCBI
UU_Cfam_GSD_1.02125,105,502 - 25,145,605 (-)NCBI
P2ry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,831,899 - 60,845,324 (+)NCBI
SpeTri2.0NW_0049364982,432,436 - 2,444,495 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,672,401 - 7,695,163 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,672,294 - 7,695,085 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
P2RY2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,461,929 - 64,481,429 (+)NCBI
ChlSab1.1 Ensembl164,479,642 - 64,480,775 (+)Ensembl
P2ry2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248173,706,017 - 3,721,045 (-)NCBI

Position Markers
PMC156657P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,945,970 - 72,946,401UniSTSGRCh37
Build 361172,623,618 - 72,624,049RGDNCBI36
Celera1170,250,571 - 70,251,002RGD
Cytogenetic Map11q13.5-q14.1UniSTS
HuRef1169,240,924 - 69,241,355UniSTS
PMC96855P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,945,282 - 72,946,062UniSTSGRCh37
Build 361172,622,930 - 72,623,710RGDNCBI36
Celera1170,249,883 - 70,250,663RGD
Cytogenetic Map11q13.5-q14.1UniSTS
HuRef1169,240,236 - 69,241,016UniSTS
D11S4331  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,946,439 - 72,946,578UniSTSGRCh37
Build 361172,624,087 - 72,624,226RGDNCBI36
Celera1170,251,040 - 70,251,179RGD
Cytogenetic Map11q13.5-q14.1UniSTS
HuRef1169,241,393 - 69,241,532UniSTS
Stanford-G3 RH Map113172.0UniSTS
NCBI RH Map11608.3UniSTS
GeneMap99-G3 RH Map113172.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1101
Count of miRNA genes:452
Interacting mature miRNAs:475
Transcripts:ENST00000311131, ENST00000393596, ENST00000393597
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 82 147 608 39 141 8 1031 806 56 29 259 716 40 902
Low 1595 2762 1088 567 1170 442 3002 903 2028 274 1048 815 131 1 922 1861 6 1
Below cutoff 752 75 21 17 338 15 274 459 1570 109 141 56 4 282 25

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_176071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_176072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005274019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005274020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005274021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK094727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY136753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX641058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ599699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ599700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG828489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN309282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000311131   ⟹   ENSP00000310305
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,218,299 - 73,236,352 (+)Ensembl
RefSeq Acc Id: ENST00000393596   ⟹   ENSP00000377221
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,218,457 - 73,235,934 (+)Ensembl
RefSeq Acc Id: ENST00000393597   ⟹   ENSP00000377222
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,218,298 - 73,235,932 (+)Ensembl
RefSeq Acc Id: NM_002564   ⟹   NP_002555
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,281 - 73,242,427 (+)NCBI
GRCh371172,928,735 - 72,953,472 (+)NCBI
Build 361172,606,992 - 72,625,045 (+)NCBI Archive
HuRef1169,224,261 - 69,248,426 (+)NCBI
CHM1_11172,813,103 - 72,837,239 (+)NCBI
Sequence:
RefSeq Acc Id: NM_176071   ⟹   NP_788085
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,562 - 73,242,427 (+)NCBI
GRCh371172,928,735 - 72,953,472 (+)NCBI
Build 361172,607,150 - 72,625,045 (+)NCBI Archive
HuRef1169,224,261 - 69,248,426 (+)NCBI
CHM1_11172,813,262 - 72,837,239 (+)NCBI
Sequence:
RefSeq Acc Id: NM_176072   ⟹   NP_788086
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,281 - 73,242,427 (+)NCBI
GRCh371172,928,735 - 72,953,472 (+)NCBI
Build 361172,606,992 - 72,625,045 (+)NCBI Archive
HuRef1169,224,261 - 69,248,426 (+)NCBI
CHM1_11172,813,103 - 72,837,239 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005274019   ⟹   XP_005274076
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,418 - 73,236,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005274020   ⟹   XP_005274077
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,946 - 73,236,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005274021   ⟹   XP_005274078
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,216,442 - 73,236,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011545074   ⟹   XP_011543376
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,707 - 73,236,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017017839   ⟹   XP_016873328
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,200,416 - 73,236,347 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001747890
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,280 - 73,243,819 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001747891
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,280 - 73,246,743 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001747892
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,280 - 73,242,335 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_788086   ⟸   NM_176072
- Sequence:
RefSeq Acc Id: NP_002555   ⟸   NM_002564
- Sequence:
RefSeq Acc Id: NP_788085   ⟸   NM_176071
- Sequence:
RefSeq Acc Id: XP_005274078   ⟸   XM_005274021
- Peptide Label: isoform X1
- UniProtKB: P41231 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005274076   ⟸   XM_005274019
- Peptide Label: isoform X1
- UniProtKB: P41231 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005274077   ⟸   XM_005274020
- Peptide Label: isoform X1
- UniProtKB: P41231 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011543376   ⟸   XM_011545074
- Peptide Label: isoform X1
- UniProtKB: P41231 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016873328   ⟸   XM_017017839
- Peptide Label: isoform X1
- UniProtKB: P41231 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000310305   ⟸   ENST00000311131
RefSeq Acc Id: ENSP00000377222   ⟸   ENST00000393597
RefSeq Acc Id: ENSP00000377221   ⟸   ENST00000393596
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6789191
Promoter ID:HG_KWN:13666
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:NM_002564,   NM_176071,   NM_176072
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,606,739 - 72,607,239 (+)MPROMDB
RGD ID:6814498
Promoter ID:HG_XEF:1514
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_001006591,   NM_001166525,   NM_008773,   NM_017255
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,616,681 - 72,617,181 (+)MPROMDB
RGD ID:6789193
Promoter ID:HG_KWN:13667
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:UC009YTM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,622,781 - 72,623,281 (+)MPROMDB
RGD ID:7221477
Promoter ID:EPDNEW_H16484
Type:initiation region
Name:P2RY2_2
Description:purinergic receptor P2Y2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16485  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,200,468 - 73,200,528EPDNEW
RGD ID:7221479
Promoter ID:EPDNEW_H16485
Type:initiation region
Name:P2RY2_1
Description:purinergic receptor P2Y2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16484  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,218,282 - 73,218,342EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5
pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
NM_002564.3(P2RY2):c.410G>A (p.Arg137Gln) single nucleotide variant Malignant melanoma [RCV000062347] Chr11:73234569 [GRCh38]
Chr11:72945614 [GRCh37]
Chr11:72623262 [NCBI36]
Chr11:11q13.4
not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_002564.4(P2RY2):c.51T>C (p.Asp17=) single nucleotide variant not provided [RCV000883955] Chr11:73234210 [GRCh38]
Chr11:72945255 [GRCh37]
Chr11:11q13.4
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8541 AgrOrtholog
COSMIC P2RY2 COSMIC
Ensembl Genes ENSG00000175591 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000310305 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000377221 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000377222 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000311131 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393596 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393597 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000175591 GTEx
HGNC ID HGNC:8541 ENTREZGENE
Human Proteome Map P2RY2 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5029 UniProtKB/Swiss-Prot
NCBI Gene 5029 ENTREZGENE
OMIM 600041 OMIM
PANTHER PTHR24231:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB P2RY2 RGD, PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y2PRNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R5N1_HUMAN UniProtKB/TrEMBL
  C6G7W1_HUMAN UniProtKB/TrEMBL
  C6G7W2_HUMAN UniProtKB/TrEMBL
  P2RY2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2R9W3 UniProtKB/Swiss-Prot
  Q96EM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 P2RY2  purinergic receptor P2Y2    purinergic receptor P2Y, G-protein coupled, 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 P2RY2  purinergic receptor P2Y, G-protein coupled, 2  P2RY2  purinergic receptor P2Y, G-protein coupled, 2  Symbol and/or name change 5135510 APPROVED