Qars1 (glutaminyl-tRNA synthetase 1)

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Gene: Qars1 (glutaminyl-tRNA synthetase 1) Rattus norvegicus

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Symbol:

Qars1

Name:

glutaminyl-tRNA synthetase 1

RGD ID:

1359448

Description:

Predicted to enable glutamine-tRNA ligase activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to be involved in several processes, including glutaminyl-tRNA aminoacylation; negative regulation of macromolecule metabolic process; and negative regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytosol. Biomarker of sciatic neuropathy. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GlnRS; glutamine--tRNA ligase; glutaminyl-tRNA synthetase; MGC94241; Qars; RGD1562301

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	QARS1 (glutaminyl-tRNA synthetase 1)	RGD	RGD
Mus musculus (house mouse):	Qars1 (glutaminyl-tRNA synthetase 1)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Qars1 (glutaminyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	QARS1 (glutaminyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	QARS1 (glutaminyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Qars1 (glutaminyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	QARS1 (glutaminyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	QARS1 (glutaminyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Qars1 (glutaminyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MS4A1 (membrane spanning 4-domains A1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	QARS1 (glutaminyl-tRNA synthetase 1)	Alliance	DIOPT (HGNC\|PANTHER)
Mus musculus (house mouse):	Qars1 (glutaminyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	qars (glutaminyl-tRNA synthetase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GLN4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	GlnRS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	qars-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	qars1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,086,243 - 118,094,274 (+)	NCBI		GRCr8
mRatBN7.2	8	109,207,705 - 109,215,738 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,207,705 - 109,215,739 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,826,044 - 114,834,073 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,025,376 - 113,033,405 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,868,016 - 110,876,045 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,297,670 - 117,305,708 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,297,670 - 117,305,702 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,642,373 - 116,650,404 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	108,504,213 - 108,512,243 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 1 (ISO)

attention deficit hyperactivity disorder (ISO)

autosomal dominant intellectual developmental disorder 43 (ISO)

autosomal recessive limb-girdle muscular dystrophy type 2P (ISO)

carnitine-acylcarnitine translocase deficiency (ISO)

Choristoma (ISO)

epilepsy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

microcephaly (ISO)

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

Prostatic Neoplasms (ISO)

sciatic neuropathy (IEP)

Sleep Initiation and Maintenance Disorders (ISO)

strabismus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

actinomycin D (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

caffeine (EXP)

chlordecone (ISO)

chloropicrin (ISO)

cisplatin (ISO)

diethylstilbestrol (ISO)

enzyme inhibitor (ISO)

fipronil (EXP)

FR900359 (ISO)

glyphosate (ISO)

ivermectin (ISO)

lead diacetate (EXP)

lead(0) (ISO)

lithium atom (EXP)

lithium hydride (EXP)

methamphetamine (EXP)

methapyrilene (ISO)

methimazole (EXP)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

mono(2-ethylhexyl) phthalate (ISO)

Monobutylphthalate (EXP)

Nutlin-3 (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pinostrobin (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (ISO)

thapsigargin (ISO)

thiram (ISO)

triadimefon (EXP)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (IEA,ISO)

glutaminyl-tRNA aminoacylation (IBA,IEA,ISO,ISS)

negative regulation of apoptotic signaling pathway (IEA,ISO)

negative regulation of DNA-templated transcription (IEA,ISO)

negative regulation of protein kinase activity (ISO)

negative regulation of stress-activated MAPK cascade (IEA,ISO)

Cellular Component

aminoacyl-tRNA synthetase multienzyme complex (IBA,IEA,ISO,ISS)

cytoplasm (IEA,ISO)

cytosol (IBA,IEA,ISO)

protein-containing complex (ISO)

Molecular Function

ATP binding (IEA)

glutamine-tRNA ligase activity (IBA,IEA,ISO,ISS)

protein binding (ISO)

protein kinase binding (IEA,ISO)

protein kinase inhibitor activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

2-hydroxyglutaric aciduria pathway (ISO)

aminoacyl-tRNA biosynthetic pathway (IEA)

glutamic acid/glutamate metabolic pathway (ISO)

homocarnosinosis pathway (ISO)

succinic semialdehyde dehydrogenase deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Expression profile of aminoacyl-tRNA synthetases in dorsal root ganglion neurons after peripheral nerve injury.	Park BS, etal., J Mol Histol. 2015 Feb;46(1):115-22. doi: 10.1007/s10735-014-9601-4. Epub 2014 Dec 3.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:10791971	PMID:11096076	PMID:12060739	PMID:19131329	PMID:19289464	PMID:23106098	PMID:24656866	PMID:26869582

Genomics

Comparative Map Data

Qars1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,086,243 - 118,094,274 (+)	NCBI		GRCr8
mRatBN7.2	8	109,207,705 - 109,215,738 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,207,705 - 109,215,739 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,826,044 - 114,834,073 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,025,376 - 113,033,405 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,868,016 - 110,876,045 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,297,670 - 117,305,708 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,297,670 - 117,305,702 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,642,373 - 116,650,404 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	108,504,213 - 108,512,243 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

QARS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	49,095,932 - 49,104,757 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	49,095,932 - 49,105,130 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	49,133,365 - 49,142,190 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	49,108,369 - 49,117,175 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	49,108,369 - 49,117,175	NCBI
Celera	3	49,090,328 - 49,099,123 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	49,191,896 - 49,201,100 (-)	NCBI		HuRef
CHM1_1	3	49,086,160 - 49,095,309 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	49,124,001 - 49,132,830 (-)	NCBI		T2T-CHM13v2.0

Qars1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	108,385,204 - 108,393,140 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	108,384,905 - 108,393,140 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	108,508,005 - 108,515,941 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,507,706 - 108,515,941 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	108,410,336 - 108,418,272 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	108,366,177 - 108,374,016 (+)	NCBI		MGSCv36	mm8
Celera	9	108,117,702 - 108,125,638 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	59.44	NCBI

Qars1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	1,092,125 - 1,100,603 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	1,093,444 - 1,100,591 (-)	NCBI	ChiLan1.0	ChiLan1.0

QARS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	49,074,506 - 49,086,475 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	49,079,274 - 49,088,442 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	49,020,310 - 49,029,443 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	50,100,216 - 50,109,357 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	50,100,216 - 50,125,112 (-)	Ensembl	panpan1.1		panPan2

QARS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	40,077,856 - 40,085,100 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	40,078,163 - 40,085,099 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	39,996,033 - 40,003,270 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	40,434,747 - 40,441,989 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	40,435,037 - 40,441,982 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	39,801,591 - 39,808,837 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	40,205,102 - 40,212,342 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	40,485,406 - 40,492,648 (+)	NCBI		UU_Cfam_GSD_1.0

Qars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	64,042,261 - 64,050,099 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	802,759 - 810,265 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	802,753 - 810,270 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

QARS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	31,715,689 - 31,723,197 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	31,715,686 - 31,723,200 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

QARS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	10,497,921 - 10,507,673 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	10,497,658 - 10,507,325 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	156,574,125 - 156,583,863 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Qars1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	3,120,958 - 3,130,757 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	3,123,877 - 3,130,787 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Qars1
24 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat

Markers in Region

RH127551

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,214,602 - 109,214,964 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,304,567 - 117,304,928	NCBI	Rnor6.0
Rnor_5.0	8	116,649,269 - 116,649,630	UniSTS	Rnor5.0
RGSC_v3.4	8	113,562,091 - 113,562,452	UniSTS	RGSC3.4
Celera	8	108,511,108 - 108,511,469	UniSTS
RH 3.4 Map	8	1118.6	UniSTS
Cytogenetic Map	8	q32	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC128721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC082002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000082628 ⟹ ENSRNOP00000071398

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,207,705 - 109,215,738 (+)	Ensembl
Rnor_6.0 Ensembl	8	117,297,670 - 117,305,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094382 ⟹ ENSRNOP00000094387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,208,004 - 109,215,739 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095098 ⟹ ENSRNOP00000086323

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,207,705 - 109,215,738 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108399 ⟹ ENSRNOP00000082239

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,207,705 - 109,215,738 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109741 ⟹ ENSRNOP00000086569

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,208,045 - 109,215,738 (+)	Ensembl

RefSeq Acc Id:

NM_001007624 ⟹ NP_001007625

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,086,243 - 118,094,274 (+)	NCBI
mRatBN7.2	8	109,207,705 - 109,215,738 (+)	NCBI
Rnor_6.0	8	117,297,670 - 117,305,702 (+)	NCBI
Rnor_5.0	8	116,642,373 - 116,650,404 (+)	NCBI
Celera	8	108,504,213 - 108,512,243 (+)	NCBI

Sequence:

show sequence

GATAGAGTCGGATTCCTAGGGCTGAGAGAGAAGAGGCCACGCCTGAGTCTACCAGCAGTTTTGT
TGCTAAACAGTTTCCCTTTCCTTGCCCAAGGCAAATTTTCTAAAGTCTCAAGGACCCAACCCTG
CCAACCGCTTAGAACCGGGAAGGCGGAAGCTAACTGCCCGGAAAAGCCAGTCCGGTCGCTCTCC
GGCTCATAAATGGCGTTGACTAGTTGGCGGGCCCCGCCTCTTTTCACTGAGGAAGGCCACCATT
GGTTCGCTTCAAAGCTTCGTATTCTTATTGGTCAATGAGCAAAGGTCGCTGTGCAGATGGGCCC
CAAAGTTTCTTTTGGTTTCCGGTGTCCCTGCTATGGCTACTCCGGATTCGCTGGCGCTGTTCAC
CGGCCTTGGCCTTAGCGAAAACAAGGCCCGCGAGACTCTCAAGAACGCGGCTTTGAGCACTCAG
CTGCGCGAGGCGGCGACCCAGGCACAGCAGACTCTAGGGTCTACCATCGACAAGGCTACTGGGA
CCCTGCTATATGGCTTGGCCTCCCGACTCAGGGATACTCGGCGTCTTTCTTTCCTTGTGGGCTA
TATAGCCAATAAGAAGATCCACACTGAGCTCCAGCTGAGCGCTGCTCTTGAATATGTTCGGAGT
CATCCCCTGGATCCCATTGATACCAAGGACTTCGAGCAGGAATGTGGTGTTGGTGTGGTGGTGA
CACCAGAGCAGATTGAGGAAGCTGTGGAGGCCACCATAAATAGGCATCGTCCACAGCTCTTAGT
GGAACGGTACCGGTTCAGCATGGGGCTGTTAATGGGAGAGGCTCGGGCTGCGCTCAGATGGGCA
GATGGCAAAATGATCAAGAACGAAGTGGATATGCAGGTCCTCCACCTGCTGGGGCCCAAAATGG
AAGCTGATCTGGAGAAGAAGCCCAAGGTGGCAAAGGCACGGCTGGAAGAAACAGACAGGAAGAC
AGCAAAAGATGTGGTGGAGAACGGTGAAGTGGCTGGCCAGACCCTGTCTCTAATGGAGCAGCTC
CGGGGAGAGGCCCTGAAGTTTCATAAACCAGGTGAGAACTATAAGACGCCAGGCTATGTGACCA
CGCCACATACCATGGATCTGCTAAAGCAGCACCTGGAGATCACTGGGGGACAGGTACGAACCCG
GTTTCCCCCAGAGCCCAATGGAATCCTGCATATTGGACATGCCAAAGCCATCAATTTCAACTTT
GGTTATGCCAAGGCCAACAACGGTATTTGTTTTCTGCGTTTTGATGACACCAACCCTGAGAAGG
AAGAAGCGAAATTCTTTACTGCTATTTATGACATGGTGACCTGGCTGGGTTACACACCTTACAA
AGTAACATACGCTTCTGACTATTTTGACCAGTTGTATGCCTGGGCTGTGGAACTGATCCGTAGG
GGTCAAGCTTATGTTTGTCATCAGAGAGGGGAAGAGCTCAAAGGCCATAACCCTTTACCTTCAC
CATGGAGAGACCGGCCTATTGAGGAATCCTTGCTGCTCTTTGAGGCAATGCGAAAGGGCAAATT
TGCAGAGGGTGAGGCCACGCTTCGAATGAAGTTGGTGATGGAAGATGGAAAGATGGACCCTGTG
GCCTATCGAGTCAAGTATACGCCACACCATCGCACAGGGGATAAATGGTGCATCTACCCCACCT
ACGACTACACACACTGTCTCTGTGATTCCATCGAGCACATCACCCACTCACTGTGTACCAAGGA
ATTCCAGGCTCGACGGTCTTCCTACTTTTGGTTGTGTAATGCACTGGATGTCTACTGCCCTGTC
CAGTGGGAATATGGCCGCCTCAATCTGCACTATGCTGTTGTCTCAAAGCGGAAGATTCTCCAGC
TTGTGGCAGCTGGTGCTGTTCGGGACTGGGATGACCCACGGCTCTTCACACTTACTGCCCTACG
ACGACGGGGTTTTCCACCTGAGGCCATCAACAACTTCTGTGCTCGGGTGGGGGTCACAGTGGCA
CAGACCACAATGGAACCTCATCTTCTGGAAGCCTGTGTGCGTGACGTGCTGAATGACACAGCCC
CGCGTGCCATGGCTGTGCTAGAGCCACTACAAGTTGTCATCACTAACTTTCCTGCTCCCAAGCC
CTTGGACATCCGAGTGCCAAACTTCCCAGCTGATGAGACCAAGGGCTTCCACCAGGTTCCTTTT
GCTTCCACTGTCTTCATTGAGAGAACGGACTTTAAGGAGGAGTCAGAACCAGGCTATAAGCGCC
TAGCCTGGGGCCAGCCTGTGGGCCTGAGACACACTGGTTACGTCATTGAACTGCAGCATGTTGT
CAGGGGCTCCAGTGGCTGTGTGGAATGCTTGGAGGTGACCTGTAGACGAGCTGATGCTGGAGAG
AAGCCCAAGGCCTTTATTCACTGGGTGTCACAGCCTCTGGTGTGTGAGATTCGCCTCTATGAGC
GACTATTCCAGCACAAGAACCCTGAAGACCCTGTCGAAGTGCCTGGTGGATTCCTAAGTGACTT
GAACCCGGCATCACTACAAGTGATTAAAGGAGCGTTGGTGGACTGCTCTGTGGCTTTGGCAAAG
CCCTTTGACAAGTTCCAGTTTGAGCGCCTTGGGTACTTCTCTGTGGATCCGGATAGCCATCAAG
GACAGGTTGTCTTCAACCGAACAGTCACACTCAAAGAAGACCCAGGCAAAGTATGAACTGAATA
CATGTGGCCCTACCTCATTCTGGAGGCTGGGGGTGCCCTCACCACCCCACACTCCATTTCAATA
AAGAGTAATTAAATCCCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001007625	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82002	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071398.2
	ENSRNOP00000082239.1
	ENSRNOP00000086323.1
	ENSRNOP00000086569.1
	ENSRNOP00000094387.1
GenBank Protein	Q66H61	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001007625 ⟸ NM_001007624

- UniProtKB:

F1LPA0 (UniProtKB/Swiss-Prot), Q66H61 (UniProtKB/TrEMBL), A0A8I6A418 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATPDSLALFTGLGLSENKARETLKNAALSTQLREAATQAQQTLGSTIDKATGTLLYGLASRLR
DTRRLSFLVGYIANKKIHTELQLSAALEYVRSHPLDPIDTKDFEQECGVGVVVTPEQIEEAVEA
TINRHRPQLLVERYRFSMGLLMGEARAALRWADGKMIKNEVDMQVLHLLGPKMEADLEKKPKVA
KARLEETDRKTAKDVVENGEVAGQTLSLMEQLRGEALKFHKPGENYKTPGYVTTPHTMDLLKQH
LEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAIYD
MVTWLGYTPYKVTYASDYFDQLYAWAVELIRRGQAYVCHQRGEELKGHNPLPSPWRDRPIEESL
LLFEAMRKGKFAEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSI
EHITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVAAGAVRDWD
DPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLEPLQ
VVITNFPAPKPLDIRVPNFPADETKGFHQVPFASTVFIERTDFKEESEPGYKRLAWGQPVGLRH
TGYVIELQHVVRGSSGCVECLEVTCRRADAGEKPKAFIHWVSQPLVCEIRLYERLFQHKNPEDP
VEVPGGFLSDLNPASLQVIKGALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGQVVFNRTVTL
KEDPGKV

hide sequence

Ensembl Acc Id:

ENSRNOP00000071398 ⟸ ENSRNOT00000082628

Ensembl Acc Id:

ENSRNOP00000086323 ⟸ ENSRNOT00000095098

Ensembl Acc Id:

ENSRNOP00000082239 ⟸ ENSRNOT00000108399

Ensembl Acc Id:

ENSRNOP00000094387 ⟸ ENSRNOT00000094382

Ensembl Acc Id:

ENSRNOP00000086569 ⟸ ENSRNOT00000109741

Protein Domains

Glutaminyl-tRNA synthetase class Ib non-specific Glutamyl/glutaminyl-tRNA synthetase class Ib Glutamyl/glutaminyl-tRNA synthetase class Ib anti- tRNA synthetases class I (E and Q) anti-codon

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66H61-F1-model_v2	AlphaFold	Q66H61	1-775	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696305

Promoter ID:

EPDNEW_R6830

Type:

multiple initiation site

Name:

Qars_1

Description:

glutaminyl-tRNA synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	117,297,998 - 117,298,058	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359448	AgrOrtholog
BioCyc Gene	G2FUF-29137	BioCyc
BioCyc Pathway	TRNA-CHARGING-PWY [tRNA charging]	BioCyc
BioCyc Pathway Image	TRNA-CHARGING-PWY	BioCyc
Ensembl Genes	ENSRNOG00000060912	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000082628.2	UniProtKB/TrEMBL
	ENSRNOT00000094382.1	UniProtKB/TrEMBL
	ENSRNOT00000095098.1	UniProtKB/TrEMBL
	ENSRNOT00000108399.1	UniProtKB/TrEMBL
	ENSRNOT00000109741.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.2420	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.10.8.1290	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.620	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131336	IMAGE-MGC_LOAD
InterPro	aa-tRNA-synth_I_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln-tRNA-synth	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln-tRNA-synth_Ib_RNA-bd_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln-tRNA-synth_Ib_RNA-bd_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln-tRNA-synth_Ib_RNA-bd_N_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln-tRNA-synth_Ib_RNA-bd_N_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln/Glu-tRNA_Ligase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glu/Gln-tRNA-synth	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glu/Gln-tRNA-synth_Ib_cat-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glu/Gln-tRNA-synth_Ib_codon-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rbsml_L25/Gln-tRNA_synth_b-brl	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L25/Gln-tRNA_synth	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	tRNA-synt_1c_C2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:290868	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94241	IMAGE-MGC_LOAD
NCBI Gene	290868	ENTREZGENE
PANTHER	GLUTAMINE--TRNA LIGASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLUTAMINE-TRNA LIGASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	tRNA-synt_1c	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	tRNA-synt_1c_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	tRNA-synt_1c_C2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	tRNA_synt_1c_R1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	tRNA_synt_1c_R2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Qars1	PhenoGen
PRINTS	TRNASYNTHGLU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	AA_TRNA_LIGASE_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000060912	RatGTEx
Superfamily-SCOP	Nucleotidylyl transferase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50715	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZUS3_RAT	UniProtKB/TrEMBL
	A0A8I6A3K2_RAT	UniProtKB/TrEMBL
	A0A8I6A418	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GL54_RAT	UniProtKB/TrEMBL
	A0A8L2R4U7_RAT	UniProtKB/TrEMBL
	F1LPA0	ENTREZGENE
	Q66H61	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	F1LPA0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-09	Qars1	glutaminyl-tRNA synthetase 1	Qars	glutaminyl-tRNA synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-29	Qars	glutaminyl-tRNA synthetase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways