Kremen2 (kringle containing transmembrane protein 2) - Rat Genome Database

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Gene: Kremen2 (kringle containing transmembrane protein 2) Rattus norvegicus
Analyze
Symbol: Kremen2
Name: kringle containing transmembrane protein 2
RGD ID: 1310795
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in limb development; negative regulation of ossification; and signal transduction. Predicted to be active in plasma membrane. Orthologous to human KREMEN2 (kringle containing transmembrane protein 2); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH bisphenol A; indole-3-methanol; N-acetyl-L-cysteine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kremen protein 2; LOC287102
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,267,986 - 13,272,103 (-)NCBIGRCr8
mRatBN7.21012,763,345 - 12,767,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,763,397 - 12,767,854 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,507,716 - 17,511,713 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01016,996,506 - 17,000,503 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,496,107 - 12,500,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,076,042 - 13,081,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,076,679 - 13,081,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01012,896,141 - 12,900,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41012,998,108 - 13,002,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11012,998,497 - 13,001,790 (-)NCBI
Celera1012,458,698 - 12,463,154 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Function and biological roles of the Dickkopf family of Wnt modulators. Niehrs C Oncogene. 2006 Dec 4;25(57):7469-81.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18505822  


Genomics

Comparative Map Data
Kremen2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,267,986 - 13,272,103 (-)NCBIGRCr8
mRatBN7.21012,763,345 - 12,767,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,763,397 - 12,767,854 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,507,716 - 17,511,713 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01016,996,506 - 17,000,503 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,496,107 - 12,500,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,076,042 - 13,081,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,076,679 - 13,081,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01012,896,141 - 12,900,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41012,998,108 - 13,002,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11012,998,497 - 13,001,790 (-)NCBI
Celera1012,458,698 - 12,463,154 (-)NCBICelera
Cytogenetic Map10q12NCBI
KREMEN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,964,275 - 2,968,380 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,964,216 - 2,968,380 (+)EnsemblGRCh38hg38GRCh38
GRCh37163,014,276 - 3,018,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,954,218 - 2,958,382 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,954,217 - 2,958,381NCBI
Celera163,219,663 - 3,223,827 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,986,708 - 2,990,875 (+)NCBIHuRef
CHM1_1163,014,197 - 3,018,364 (+)NCBICHM1_1
T2T-CHM13v2.0162,990,954 - 2,995,059 (+)NCBIT2T-CHM13v2.0
Kremen2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391723,960,173 - 23,965,305 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1723,960,171 - 23,964,807 (-)EnsemblGRCm39 Ensembl
GRCm381723,741,199 - 23,745,960 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1723,741,197 - 23,745,833 (-)EnsemblGRCm38mm10GRCm38
MGSCv371723,878,166 - 23,882,796 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,468,821 - 23,473,451 (-)NCBIMGSCv36mm8
Celera1724,235,074 - 24,239,685 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.03NCBI
Kremen2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,376,466 - 14,381,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,376,466 - 14,381,106 (-)NCBIChiLan1.0ChiLan1.0
KREMEN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,508,929 - 3,512,922 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1167,287,319 - 7,292,309 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,905,397 - 1,910,249 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,078,086 - 3,082,325 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,078,086 - 3,082,325 (+)Ensemblpanpan1.1panPan2
KREMEN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,214,853 - 38,218,679 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,215,221 - 38,218,299 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,455,350 - 39,459,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,525,433 - 38,529,242 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,525,794 - 38,529,313 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,211,195 - 38,215,004 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,183,722 - 38,187,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,659,494 - 38,663,303 (-)NCBIUU_Cfam_GSD_1.0
Kremen2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,501,185 - 105,508,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,201,812 - 1,205,246 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,201,008 - 1,205,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KREMEN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,214,248 - 39,218,776 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,214,251 - 39,218,805 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,483,965 - 40,485,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KREMEN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,695,217 - 2,707,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,697,410 - 2,707,606 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,126,565 - 28,131,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kremen2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824707,798 - 711,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824702,648 - 711,615 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kremen2
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:158
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000005718
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat

Markers in Region
UniSTS:496615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21012,764,706 - 12,764,905 (+)MAPPERmRatBN7.2
Rnor_6.01013,077,989 - 13,078,187NCBIRnor6.0
Rnor_5.01012,897,451 - 12,897,649UniSTSRnor5.0
RGSC_v3.41012,999,418 - 12,999,616UniSTSRGSC3.4
Celera1012,460,008 - 12,460,206UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 2 10 49 36 38 12 14 12 6 75 36 37 17 51 26

Sequence


Ensembl Acc Id: ENSRNOT00000005718   ⟹   ENSRNOP00000005718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1012,763,397 - 12,767,854 (-)Ensembl
Rnor_6.0 Ensembl1013,076,679 - 13,081,136 (-)Ensembl
RefSeq Acc Id: NM_001395107   ⟹   NP_001382036
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,267,986 - 13,271,986 (-)NCBI
mRatBN7.21012,763,397 - 12,767,397 (-)NCBI
RefSeq Acc Id: XM_063268550   ⟹   XP_063124620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,267,986 - 13,272,103 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001382036 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124620 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03773 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005718.2
Ensembl Acc Id: ENSRNOP00000005718   ⟸   ENSRNOT00000005718
RefSeq Acc Id: NP_001382036   ⟸   NM_001395107
- Peptide Label: precursor
- UniProtKB: A6HCL8 (UniProtKB/TrEMBL),   D4ADS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124620   ⟸   XM_063268550
- Peptide Label: isoform X1
- UniProtKB: A6HCL8 (UniProtKB/TrEMBL),   D4ADS5 (UniProtKB/TrEMBL)
Protein Domains
CUB   Kringle   WSC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADS5-F1-model_v2 AlphaFold D4ADS5 1-468 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310795 AgrOrtholog
BioCyc Gene G2FUF-25908 BioCyc
Ensembl Genes ENSRNOG00000004122 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005718.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.20.10 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
InterPro CUB UniProtKB/TrEMBL
  Kremen UniProtKB/TrEMBL
  Kremen_rcpt UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Kringle_CS UniProtKB/TrEMBL
  Kringle_sf UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
  WSC_carb-bd UniProtKB/TrEMBL
NCBI Gene 287102 ENTREZGENE
PANTHER KREMEN PROTEIN UniProtKB/TrEMBL
  KREMEN PROTEIN 2 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  WSC UniProtKB/TrEMBL
PhenoGen Kremen2 PhenoGen
PIRSF Kremen UniProtKB/TrEMBL
PRINTS KRINGLE UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/TrEMBL
  WSC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004122 RatGTEx
SMART CUB UniProtKB/TrEMBL
  SM00130 UniProtKB/TrEMBL
  WSC UniProtKB/TrEMBL
Superfamily-SCOP CUB UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
UniProt A6HCL8 ENTREZGENE, UniProtKB/TrEMBL
  D4ADS5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Kremen2  kringle containing transmembrane protein 2   Kremen2_predicted  kringle containing transmembrane protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kremen2_predicted  kringle containing transmembrane protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED