Armh4 (armadillo-like helical domain containing 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Armh4 (armadillo-like helical domain containing 4) Rattus norvegicus
Analyze
Symbol: Armh4
Name: armadillo-like helical domain containing 4
RGD ID: 1310110
Description: Predicted to enable TORC2 complex binding activity. Predicted to be involved in regulation of TORC2 signaling and regulation of inflammatory response. Predicted to be located in membrane. Orthologous to human ARMH4 (armadillo like helical domain containing 4); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 3',5'-cyclic AMP; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: armadillo-like helical domain-containing protein 4; hypothetical protein LOC361032; LOC361032; RGD1310110; similar to 3632451O06Rik protein; uncharacterized protein C14orf37 homolog; uncharacterized protein LOC361032
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,455,478 - 25,556,569 (-)NCBIGRCr8
mRatBN7.21522,975,895 - 23,076,986 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1522,975,895 - 23,076,949 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1525,753,156 - 25,854,222 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01526,714,490 - 26,815,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01524,961,684 - 25,062,756 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01526,586,359 - 26,687,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1526,587,179 - 26,678,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01530,512,209 - 30,613,262 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41525,680,073 - 25,781,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11525,696,592 - 25,796,832 (-)NCBI
Celera1523,343,119 - 23,443,765 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Armh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,455,478 - 25,556,569 (-)NCBIGRCr8
mRatBN7.21522,975,895 - 23,076,986 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1522,975,895 - 23,076,949 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1525,753,156 - 25,854,222 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01526,714,490 - 26,815,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01524,961,684 - 25,062,756 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01526,586,359 - 26,687,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1526,587,179 - 26,678,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01530,512,209 - 30,613,262 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41525,680,073 - 25,781,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11525,696,592 - 25,796,832 (-)NCBI
Celera1523,343,119 - 23,443,765 (-)NCBICelera
Cytogenetic Map15p14NCBI
ARMH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381458,000,761 - 58,152,213 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1457,999,735 - 58,298,139 (-)EnsemblGRCh38hg38GRCh38
GRCh371458,467,479 - 58,618,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361457,540,561 - 57,688,600 (-)NCBINCBI36Build 36hg18NCBI36
Build 341457,540,560 - 57,688,600NCBI
Celera1438,520,760 - 38,668,792 (-)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1438,636,789 - 38,784,667 (-)NCBIHuRef
CHM1_11458,409,339 - 58,557,390 (-)NCBICHM1_1
T2T-CHM13v2.01452,207,688 - 52,359,170 (-)NCBIT2T-CHM13v2.0
Armh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391449,919,017 - 50,020,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1449,913,409 - 50,020,840 (-)EnsemblGRCm39 Ensembl
GRCm381449,681,560 - 49,783,480 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1449,675,952 - 49,783,383 (-)EnsemblGRCm38mm10GRCm38
MGSCv371450,301,694 - 50,403,042 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361448,603,511 - 48,705,279 (-)NCBIMGSCv36mm8
Celera1445,883,049 - 46,001,900 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1425.78NCBI
Armh4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546611,777,693 - 11,880,257 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546611,771,258 - 11,889,444 (-)NCBIChiLan1.0ChiLan1.0
ARMH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21559,120,298 - 59,276,345 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11458,336,812 - 58,492,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01438,600,338 - 38,746,397 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11456,870,406 - 57,003,380 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1456,870,406 - 57,003,380 (-)Ensemblpanpan1.1panPan2
ARMH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1833,411,953 - 33,575,083 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl833,412,665 - 33,551,054 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha833,174,352 - 33,336,785 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0833,651,725 - 33,816,624 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl833,651,740 - 33,782,102 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1833,267,316 - 33,429,880 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0833,332,566 - 33,497,069 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0833,707,637 - 33,872,149 (-)NCBIUU_Cfam_GSD_1.0
Armh4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864071,623,762 - 71,738,159 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364952,456,147 - 2,558,354 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364952,452,971 - 2,567,862 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARMH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1187,103,809 - 187,259,015 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11187,118,498 - 187,259,069 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21208,103,943 - 208,170,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARMH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12435,195,374 - 35,344,585 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2435,196,061 - 35,344,708 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605323,428,549 - 23,584,010 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Armh4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248843,034,414 - 3,223,161 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248843,027,799 - 3,225,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Armh4
637 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:89
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000041420
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 46 113 85 84 53 25 53 6 209 94 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000041420   ⟹   ENSRNOP00000051182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1522,975,895 - 23,076,949 (-)Ensembl
Rnor_6.0 Ensembl1526,587,179 - 26,678,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106281   ⟹   ENSRNOP00000089792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1522,975,895 - 23,075,820 (-)Ensembl
RefSeq Acc Id: NM_001108374   ⟹   NP_001101844
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81525,455,478 - 25,556,532 (-)NCBI
mRatBN7.21522,975,895 - 23,076,949 (-)NCBI
Rnor_6.01526,586,359 - 26,687,412 (-)NCBI
Rnor_5.01530,512,209 - 30,613,262 (-)NCBI
RGSC_v3.41525,680,073 - 25,781,128 (-)RGD
Celera1523,343,119 - 23,443,765 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093475   ⟹   XP_038949403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81525,455,609 - 25,556,569 (-)NCBI
mRatBN7.21522,976,026 - 23,076,986 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101844 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949403 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88394 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051182.5
  ENSRNOP00000089792.1
RefSeq Acc Id: NP_001101844   ⟸   NM_001108374
- UniProtKB: D3ZYI3 (UniProtKB/TrEMBL),   A6KE89 (UniProtKB/TrEMBL),   A0A8I6GIE0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051182   ⟸   ENSRNOT00000041420
RefSeq Acc Id: XP_038949403   ⟸   XM_039093475
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GIE0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089792   ⟸   ENSRNOT00000106281

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYI3-F1-model_v2 AlphaFold D3ZYI3 1-768 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310110 AgrOrtholog
BioCyc Gene G2FUF-14100 BioCyc
Ensembl Genes ENSRNOG00000031849 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041420.6 UniProtKB/TrEMBL
  ENSRNOT00000106281.1 UniProtKB/TrEMBL
InterPro DUF4696 UniProtKB/TrEMBL
KEGG Report rno:361032 UniProtKB/TrEMBL
NCBI Gene 361032 ENTREZGENE
PANTHER ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  PTHR21585 UniProtKB/TrEMBL
Pfam DUF4696 UniProtKB/TrEMBL
PhenoGen Armh4 PhenoGen
RatGTEx ENSRNOG00000031849 RatGTEx
UniProt A0A8I6GIE0 ENTREZGENE, UniProtKB/TrEMBL
  A6KE89 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-12 Armh4  armadillo-like helical domain containing 4  RGD1310110  similar to 3632451O06Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1310110  similar to 3632451O06Rik protein   RGD1310110_predicted  similar to 3632451O06Rik protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1310110_predicted  similar to 3632451O06Rik protein (predicted)  LOC361032_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361032_predicted  similar to 3632451O06Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL