Rnaset2 (ribonuclease T2) - Rat Genome Database

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Gene: Rnaset2 (ribonuclease T2) Rattus norvegicus
Analyze
Symbol: Rnaset2
Name: ribonuclease T2
RGD ID: 1309918
Description: Predicted to enable RNA endonuclease activity. Predicted to be involved in RNA catabolic process. Predicted to be located in endoplasmic reticulum lumen; extracellular space; and lysosome. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC292306
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Rnaset2-ps1  
Allele / Splice: Rnaset2em1Sage  
Genetic Models: SD-Rnaset2em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,133,532 - 55,150,701 (+)NCBIGRCr8
mRatBN7.2152,576,344 - 52,603,151 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,585,929 - 52,603,147 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,293,564 - 53,310,743 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,279,147 - 59,296,316 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,369,172 - 53,386,351 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,174,879 - 53,192,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,174,879 - 53,192,048 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,425,133 - 54,442,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,227,491 - 47,244,660 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1147,229,790 - 47,247,605 (+)NCBI
Celera148,348,850 - 48,366,056 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
ethyl methanesulfonate  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection. De Vito A, etal., Cancers (Basel). 2020 Mar 18;12(3). pii: cancers12030717. doi: 10.3390/cancers12030717.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield. Ou J, etal., Nat Commun. 2019 Mar 6;10(1):1078. doi: 10.1038/s41467-019-08902-x.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Human recombinant RNASET2: A potential anti-cancer drug. Roiz L, etal., Oncoscience. 2016 Mar 4;3(2):71-84. doi: 10.18632/oncoscience.295. eCollection 2016.
11. RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory. Sinkevicius KW, etal., Dis Model Mech. 2018 Jun 27;11(6). pii: dmm.032631. doi: 10.1242/dmm.032631.
12. New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1α. Uccella S, etal., Hum Pathol. 2018 Sep;79:66-76. doi: 10.1016/j.humpath.2018.04.028. Epub 2018 May 12.
13. Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes. Wang Y, etal., Int J Cancer. 2018 Apr 15;142(8):1602-1610. doi: 10.1002/ijc.31182. Epub 2017 Dec 12.
14. Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma. Zeng Z, etal., Front Oncol. 2020 May 22;10:836. doi: 10.3389/fonc.2020.00836. eCollection 2020.
Additional References at PubMed
PMID:12477932   PMID:16502470   PMID:16620762   PMID:22735700   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Rnaset2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,133,532 - 55,150,701 (+)NCBIGRCr8
mRatBN7.2152,576,344 - 52,603,151 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,585,929 - 52,603,147 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,293,564 - 53,310,743 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,279,147 - 59,296,316 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,369,172 - 53,386,351 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,174,879 - 53,192,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,174,879 - 53,192,048 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,425,133 - 54,442,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,227,491 - 47,244,660 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1147,229,790 - 47,247,605 (+)NCBI
Celera148,348,850 - 48,366,056 (+)NCBICelera
Cytogenetic Map1q12NCBI
RNASET2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386166,922,113 - 166,956,550 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6166,922,113 - 166,957,191 (-)EnsemblGRCh38hg38GRCh38
GRCh376167,335,601 - 167,370,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366167,262,994 - 167,290,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 346167,313,416 - 167,340,488NCBI
Celera6168,084,182 - 168,111,263 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6164,815,617 - 164,842,699 (-)NCBIHuRef
CHM1_16167,605,634 - 167,632,656 (-)NCBICHM1_1
T2T-CHM13v2.06168,304,858 - 168,339,306 (-)NCBIT2T-CHM13v2.0
Rnaset2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,347,412 - 8,367,078 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,334,277 - 8,366,929 (-)EnsemblGRCm39 Ensembl
GRCm38178,128,580 - 8,148,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,115,445 - 8,148,097 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl176,970,634 - 7,011,299 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,321,463 - 8,340,653 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36178,320,941 - 8,340,962NCBIMGSCv36mm8
Cytogenetic Map17A1NCBI
cM Map174.87NCBI
Rnaset2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543915,098,114 - 15,125,413 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543915,098,210 - 15,122,015 (+)NCBIChiLan1.0ChiLan1.0
RNASET2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25187,136,419 - 187,164,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16185,032,560 - 185,060,195 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06164,895,396 - 164,923,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16169,872,780 - 169,899,599 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6169,872,780 - 169,899,599 (-)Ensemblpanpan1.1panPan2
RNASET2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,779,453 - 54,820,697 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,569,589 - 55,610,750 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,960,522 - 55,001,716 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,951,257 - 55,001,687 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,857,510 - 54,898,703 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,706,105 - 54,747,457 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0155,331,031 - 55,372,416 (-)NCBIUU_Cfam_GSD_1.0
Rnaset2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946149,288,114 - 149,304,873 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648916,540,562 - 16,555,670 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648916,540,558 - 16,555,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASET2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.112,146,707 - 2,164,768 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213,289,720 - 3,307,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNASET2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11394,670,376 - 94,702,585 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1394,668,580 - 94,702,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604066,485,168 - 66,512,964 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnaset2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478512,383,709 - 12,409,069 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnaset2
112 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5
Count of miRNA genes:5
Interacting mature miRNAs:5
Transcripts:ENSRNOT00000017601
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
BI276897  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,602,897 - 52,603,060 (+)MAPPERmRatBN7.2
Rnor_6.0153,191,795 - 53,191,957NCBIRnor6.0
Rnor_5.0154,442,049 - 54,442,211UniSTSRnor5.0
RGSC_v3.4147,244,407 - 47,244,569UniSTSRGSC3.4
Celera148,365,803 - 48,365,965UniSTS
RH 3.4 Map1625.8UniSTS
Cytogenetic Map1q11UniSTS


Genetic Models
This gene Rnaset2 is modified in the following models/strains:
SD-Rnaset2em1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017601   ⟹   ENSRNOP00000017601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,585,929 - 52,603,147 (+)Ensembl
Rnor_6.0 Ensembl153,174,879 - 53,192,048 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084628   ⟹   ENSRNOP00000075037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,585,929 - 52,603,147 (+)Ensembl
Rnor_6.0 Ensembl153,174,975 - 53,191,952 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118408   ⟹   ENSRNOP00000094634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,586,012 - 52,603,147 (+)Ensembl
RefSeq Acc Id: NM_001106210   ⟹   NP_001099680
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,133,532 - 55,150,701 (+)NCBI
mRatBN7.2152,585,980 - 52,603,151 (+)NCBI
Rnor_6.0153,174,879 - 53,192,048 (+)NCBI
Rnor_5.0154,425,133 - 54,442,302 (+)NCBI
RGSC_v3.4147,227,491 - 47,244,660 (+)RGD
Celera148,348,850 - 48,366,056 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099680 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68957 (Get FASTA)   NCBI Sequence Viewer  
  EDL83132 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017601.5
  ENSRNOP00000075037.2
  ENSRNOP00000094634.1
RefSeq Acc Id: NP_001099680   ⟸   NM_001106210
- Peptide Label: precursor
- UniProtKB: D3ZCH6 (UniProtKB/TrEMBL),   A6KK44 (UniProtKB/TrEMBL),   A0A8I6ALG0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075037   ⟸   ENSRNOT00000084628
Ensembl Acc Id: ENSRNOP00000017601   ⟸   ENSRNOT00000017601
Ensembl Acc Id: ENSRNOP00000094634   ⟸   ENSRNOT00000118408

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9L0-F1-model_v2 AlphaFold A0A0G2K9L0 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689632
Promoter ID:EPDNEW_R156
Type:initiation region
Name:Rnaset2_1
Description:ribonuclease T2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0153,174,950 - 53,175,010EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309918 AgrOrtholog
BioCyc Gene G2FUF-61507 BioCyc
Ensembl Genes ENSRNOG00000013190 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017601.7 UniProtKB/TrEMBL
  ENSRNOT00000084628.2 UniProtKB/TrEMBL
  ENSRNOT00000118408.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.730.10 UniProtKB/TrEMBL
InterPro Ribonuclease_T2_eukaryotic UniProtKB/TrEMBL
  RNase_T2 UniProtKB/TrEMBL
  RNase_T2-like_sf UniProtKB/TrEMBL
  RNase_T2_AS UniProtKB/TrEMBL
  RNase_T2_His_AS_2 UniProtKB/TrEMBL
KEGG Report rno:292306 UniProtKB/TrEMBL
NCBI Gene 292306 ENTREZGENE
PANTHER RIBONUCLEASE T2 UniProtKB/TrEMBL
  RNase_T2 UniProtKB/TrEMBL
Pfam Ribonuclease_T2 UniProtKB/TrEMBL
PhenoGen Rnaset2 PhenoGen
PROSITE RNASE_T2_1 UniProtKB/TrEMBL
  RNASE_T2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013190 RatGTEx
Superfamily-SCOP RNase_T2 UniProtKB/TrEMBL
UniProt A0A0G2K9L0_RAT UniProtKB/TrEMBL
  A0A8I6ALG0 ENTREZGENE, UniProtKB/TrEMBL
  A6KK44 ENTREZGENE, UniProtKB/TrEMBL
  B5DF79_RAT UniProtKB/TrEMBL
  D3ZCH6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Rnaset2  ribonuclease T2   Rnaset2_predicted  ribonuclease T2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rnaset2_predicted  ribonuclease T2 (predicted)      Symbol and Name status set to approved 70820 APPROVED