Tle2 (TLE family member 2, transcriptional corepressor) - Rat Genome Database

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Gene: Tle2 (TLE family member 2, transcriptional corepressor) Rattus norvegicus
Analyze
Symbol: Tle2
Name: TLE family member 2, transcriptional corepressor
RGD ID: 1306665
Description: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Predicted to be located in focal adhesion and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TLE2 (TLE family member 2, transcriptional corepressor); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299636; MGC124808; transducin-like enhancer of split 2; transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 2 homolog; transducin-like enhancer of split 2, homolog of Drosophila E(spl); transducin-like enhancer protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,769,815 - 8,789,493 (-)NCBIGRCr8
mRatBN7.278,119,049 - 8,135,385 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,119,053 - 8,134,306 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,005,436 - 11,020,581 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,881,099 - 12,896,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,748,444 - 10,763,593 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0710,988,536 - 11,003,957 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,988,532 - 11,003,785 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,155,630 - 11,171,898 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,592,238 - 9,607,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,592,359 - 9,610,035 (-)NCBI
Celera76,310,093 - 6,325,344 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19460168   PMID:22664934  


Genomics

Comparative Map Data
Tle2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,769,815 - 8,789,493 (-)NCBIGRCr8
mRatBN7.278,119,049 - 8,135,385 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,119,053 - 8,134,306 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,005,436 - 11,020,581 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,881,099 - 12,896,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,748,444 - 10,763,593 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0710,988,536 - 11,003,957 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,988,532 - 11,003,785 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,155,630 - 11,171,898 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,592,238 - 9,607,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,592,359 - 9,610,035 (-)NCBI
Celera76,310,093 - 6,325,344 (-)NCBICelera
Cytogenetic Map7q11NCBI
TLE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,997,644 - 3,047,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,997,639 - 3,047,635 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,997,642 - 3,047,633 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,948,636 - 2,980,022 (-)NCBINCBI36Build 36hg18NCBI36
Build 34192,948,636 - 2,980,022NCBI
Celera192,931,704 - 2,981,680 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,765,065 - 2,828,954 (-)NCBIHuRef
CHM1_1192,997,564 - 3,047,782 (-)NCBICHM1_1
T2T-CHM13v2.0192,971,143 - 3,021,120 (-)NCBIT2T-CHM13v2.0
Tle2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,410,573 - 81,435,018 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,410,395 - 81,426,679 (+)EnsemblGRCm39 Ensembl
GRCm381081,574,739 - 81,592,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,574,561 - 81,590,845 (+)EnsemblGRCm38mm10GRCm38
MGSCv371081,038,277 - 81,053,590 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,978,661 - 80,993,974 (+)NCBIMGSCv36mm8
Celera1082,598,713 - 82,614,026 (+)NCBICelera
Cytogenetic Map10C1NCBI
Tle2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,347,496 - 5,368,385 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,347,496 - 5,366,743 (+)NCBIChiLan1.0ChiLan1.0
TLE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,392,974 - 7,425,279 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,625,793 - 6,658,097 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,023,018 - 2,055,317 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,977,739 - 3,004,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,972,618 - 3,004,565 (-)Ensemblpanpan1.1panPan2
TLE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,138,654 - 56,157,625 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,137,746 - 56,157,583 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,935,870 - 55,955,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,870,912 - 56,890,381 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,870,071 - 56,890,376 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,926,005 - 55,945,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,410,226 - 56,429,622 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,608,966 - 56,628,210 (+)NCBIUU_Cfam_GSD_1.0
Tle2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,100,358 - 216,116,520 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,718,283 - 1,734,409 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,718,263 - 1,734,408 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,510,004 - 75,536,804 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,510,276 - 75,536,812 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,035,331 - 76,057,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,770,558 - 2,792,228 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660815,762,811 - 5,815,166 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tle2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,131,452 - 6,149,377 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,131,418 - 6,149,388 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tle2
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:97
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000061279
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
WI-17546  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,132,039 - 8,132,626 (+)MAPPERmRatBN7.2
Rnor_6.0711,001,526 - 11,002,112NCBIRnor6.0
Rnor_5.0711,168,620 - 11,169,206UniSTSRnor5.0
RGSC_v3.479,605,228 - 9,605,814UniSTSRGSC3.4
Celera76,323,085 - 6,323,671UniSTS
Cytogenetic Map7q11UniSTS
MARC_22091-22263:1042842227:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,121,990 - 8,122,504 (+)MAPPERmRatBN7.2
Rnor_6.0710,991,478 - 10,991,991NCBIRnor6.0
Rnor_5.0711,158,572 - 11,159,085UniSTSRnor5.0
RGSC_v3.479,595,179 - 9,595,692UniSTSRGSC3.4
Celera76,313,036 - 6,313,549UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC100652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000061279   ⟹   ENSRNOP00000057991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,119,053 - 8,134,306 (-)Ensembl
Rnor_6.0 Ensembl710,988,537 - 11,003,785 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084006   ⟹   ENSRNOP00000071657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,119,053 - 8,134,306 (-)Ensembl
Rnor_6.0 Ensembl710,988,532 - 11,001,933 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115215   ⟹   ENSRNOP00000086408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,119,053 - 8,134,306 (-)Ensembl
RefSeq Acc Id: NM_001039013   ⟹   NP_001034102
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,816 - 8,785,065 (-)NCBI
mRatBN7.278,119,050 - 8,134,299 (-)NCBI
Rnor_6.0710,988,537 - 11,003,785 (-)NCBI
Rnor_5.0711,155,630 - 11,171,898 (-)NCBI
RGSC_v3.479,592,238 - 9,607,487 (-)RGD
Celera76,310,093 - 6,325,344 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240889   ⟹   XP_006240951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,363 (-)NCBI
mRatBN7.278,119,049 - 8,134,588 (-)NCBI
Rnor_6.0710,988,536 - 11,003,957 (-)NCBI
Rnor_5.0711,155,630 - 11,171,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240893   ⟹   XP_006240955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,363 (-)NCBI
mRatBN7.278,119,049 - 8,134,589 (-)NCBI
Rnor_6.0710,988,536 - 11,003,957 (-)NCBI
Rnor_5.0711,155,630 - 11,171,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078653   ⟹   XP_038934581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,789,493 (-)NCBI
mRatBN7.278,119,049 - 8,134,591 (-)NCBI
RefSeq Acc Id: XM_039078654   ⟹   XP_038934582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,789,493 (-)NCBI
mRatBN7.278,119,049 - 8,135,385 (-)NCBI
RefSeq Acc Id: XM_039078656   ⟹   XP_038934584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,365 (-)NCBI
mRatBN7.278,119,049 - 8,134,591 (-)NCBI
RefSeq Acc Id: XM_039078657   ⟹   XP_038934585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,365 (-)NCBI
mRatBN7.278,119,049 - 8,134,591 (-)NCBI
RefSeq Acc Id: XM_039078658   ⟹   XP_038934586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,365 (-)NCBI
mRatBN7.278,119,049 - 8,134,591 (-)NCBI
RefSeq Acc Id: XM_039078659   ⟹   XP_038934587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,364 (-)NCBI
mRatBN7.278,119,049 - 8,134,590 (-)NCBI
RefSeq Acc Id: XM_039078660   ⟹   XP_038934588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,369 (-)NCBI
mRatBN7.278,119,049 - 8,134,595 (-)NCBI
RefSeq Acc Id: XM_039078661   ⟹   XP_038934589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,773,640 - 8,785,372 (-)NCBI
mRatBN7.278,122,521 - 8,134,598 (-)NCBI
RefSeq Acc Id: XM_039078664   ⟹   XP_038934592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,773,287 - 8,785,372 (-)NCBI
mRatBN7.278,122,521 - 8,134,598 (-)NCBI
RefSeq Acc Id: XM_063263177   ⟹   XP_063119247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,363 (-)NCBI
RefSeq Acc Id: XM_063263178   ⟹   XP_063119248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,363 (-)NCBI
RefSeq Acc Id: XM_063263179   ⟹   XP_063119249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,362 (-)NCBI
RefSeq Acc Id: XM_063263180   ⟹   XP_063119250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,363 (-)NCBI
RefSeq Acc Id: XM_063263181   ⟹   XP_063119251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,769,815 - 8,785,363 (-)NCBI
RefSeq Acc Id: XR_005486568
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,773,248 - 8,785,372 (-)NCBI
mRatBN7.278,122,491 - 8,134,598 (-)NCBI
RefSeq Acc Id: NP_001034102   ⟸   NM_001039013
- UniProtKB: Q496Z7 (UniProtKB/TrEMBL),   A0A8I6A8Q2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240955   ⟸   XM_006240893
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K109 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240951   ⟸   XM_006240889
- Peptide Label: isoform X4
- UniProtKB: A6K867 (UniProtKB/TrEMBL),   A0A0G2K109 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057991   ⟸   ENSRNOT00000061279
Ensembl Acc Id: ENSRNOP00000071657   ⟸   ENSRNOT00000084006
RefSeq Acc Id: XP_038934582   ⟸   XM_039078654
- Peptide Label: isoform X1
- UniProtKB: A6K868 (UniProtKB/TrEMBL),   A0A0G2K109 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934588   ⟸   XM_039078660
- Peptide Label: isoform X8
- UniProtKB: A0A0G2K109 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934584   ⟸   XM_039078656
- Peptide Label: isoform X1
- UniProtKB: A6K868 (UniProtKB/TrEMBL),   A0A0G2K109 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934585   ⟸   XM_039078657
- Peptide Label: isoform X1
- UniProtKB: A6K868 (UniProtKB/TrEMBL),   A0A0G2K109 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934586   ⟸   XM_039078658
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K109 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934581   ⟸   XM_039078653
- Peptide Label: isoform X1
- UniProtKB: A6K868 (UniProtKB/TrEMBL),   A0A0G2K109 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934587   ⟸   XM_039078659
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K109 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934592   ⟸   XM_039078664
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038934589   ⟸   XM_039078661
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000086408   ⟸   ENSRNOT00000115215
RefSeq Acc Id: XP_063119247   ⟸   XM_063263177
- Peptide Label: isoform X4
- UniProtKB: A6K867 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119250   ⟸   XM_063263180
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063119248   ⟸   XM_063263178
- Peptide Label: isoform X4
- UniProtKB: A6K867 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119251   ⟸   XM_063263181
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063119249   ⟸   XM_063263179
- Peptide Label: isoform X6
Protein Domains
Groucho/TLE N-terminal Q-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTW9-F1-model_v2 AlphaFold E9PTW9 1-696 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694966
Promoter ID:EPDNEW_R5491
Type:multiple initiation site
Name:Tle2_1
Description:transducin-like enhancer of split 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,003,794 - 11,003,854EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306665 AgrOrtholog
BioCyc Gene G2FUF-35041 BioCyc
Ensembl Genes ENSRNOG00000005874 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061279.3 UniProtKB/TrEMBL
  ENSRNOT00000084006.2 UniProtKB/TrEMBL
  ENSRNOT00000115215.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7932424 IMAGE-MGC_LOAD
InterPro Groucho/TLE_N UniProtKB/TrEMBL
  Groucho_enhance UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:299636 UniProtKB/TrEMBL
MGC_CLONE MGC:124808 IMAGE-MGC_LOAD
NCBI Gene 299636 ENTREZGENE
PANTHER PTHR10814 UniProtKB/TrEMBL
  TRANSDUCIN-LIKE ENHANCER PROTEIN 2 UniProtKB/TrEMBL
Pfam TLE_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Tle2 PhenoGen
PRINTS GROUCHOFAMLY UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005874 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K109 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8Q2 ENTREZGENE, UniProtKB/TrEMBL
  A6K867 ENTREZGENE, UniProtKB/TrEMBL
  A6K868 ENTREZGENE, UniProtKB/TrEMBL
  E9PTW9_RAT UniProtKB/TrEMBL
  Q496Z7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Tle2  TLE family member 2, transcriptional corepressor  Tle2  transducin-like enhancer of split 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-13 Tle2  transducin-like enhancer of split 2  Tle2  transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Tle2  transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)  Tle2  transducin-like enhancer of split 2, homolog of Drosophila E(spl)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tle2  transducin-like enhancer of split 2, homolog of Drosophila E(spl)  Tle2_predicted  transducin-like enhancer of split 2, homolog of Drosophila E(spl) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tle2_predicted  transducin-like enhancer of split 2, homolog of Drosophila E(spl) (predicted)      Symbol and Name status set to approved 70820 APPROVED